Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways.
In: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Jg. 120 (2019-12-01), S. 109567
Online
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Zugriff:
Cellular inflammation has been recognized as the leading factor in numerous diseases, causing either cell death, organ-specific damage, or genesis of different cancers. Icariin, a flavonol glucoside, extracted from Herba Epimedii, offers various pharmacological activities, including reducing inflammation and an antioxidant effect. We aimed to evaluate the anti-inflammatory mechanisms of icariin focussing on both HO-1/Nrf2 and NF-kB pathways. Acute inflammation was induced in rats via carrageenan in this study. Icariin was injected in a dose of 50 mg/kg. Icariin significantly reduced paw swelling in carrageenan-injected animals. It also ameliorated carrageenan-induced paw histopathological alterations. Icariin significantly increased paw enzymatic and non-enzymatic antioxidants. It decreased paw lipid peroxidation. Icariin decreased paw levels of inflammatory cytokines and NF-kB. The immunohistochemical analysis showed that icariin significantly increased Nrf2 gene expression while decreasing NF-kB and COX-2 gene expression. RT-PCR analysis revealed that icariin injection significantly increased both Nrf2 and HO-1 expression of mRNA. The results of this study collectively show that icariin improved carrageenan-induced paw edema by modulating HO-1/Nrf2 and NF-ĸB signaling.
(Copyright © 2019 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)
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Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways.
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Autor/in / Beteiligte Person: | El-Shitany, NA ; Eid, BG |
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Zeitschrift: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Jg. 120 (2019-12-01), S. 109567 |
Veröffentlichung: | Paris : Editions Scientifiques Elsevier ; <i>Original Publication</i>: New York, N.Y. : Masson Pub. USA, Inc., c1982-, 2019 |
Medientyp: | academicJournal |
ISSN: | 1950-6007 (electronic) |
DOI: | 10.1016/j.biopha.2019.109567 |
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