In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds.
In: Natural product research, Jg. 35 (2021-08-01), Heft 16, S. 2793
Online
academicJournal
Zugriff:
The WSE is a highly polar, gummy and mucilaginous bioactive content of the Nigella sativa (L.) seeds. This study reports the anxiolytic and anti-inflammatory effects of WSE investigated using Elevated Plus Maze (EPM) and Hole-Board Test (HBT) in adult mice and human RBCs haemolysis inhibition and protein denaturation respectively. The oral WSE treatment (100 & 200 mg/kg b.w/day) for 72 hours has exhibited slightly better anxiolytic effect ( p < 0.05) through the time span (92.33 & 93.33 s) spent in the opened arms of EPM vs . diazepam (1 mg/kg b.w i.p/day; 69.33 s). In HBT, only WSE (200 mg/kg b.w/day) has shown a promising number of mean head pokes (13.27 times/min) vs . diazepam (12.87 times/min). The WSE (62.5-500 µg/mL) exposure has exhibited 40.14-72.18% protection against lysis of RBCs vs . aspirin (57.04-71.48%) whilst 62.67-67.66% inhibition of protein denaturation vs . diclofenac sodium (43.11-80.64%). The current findings suggested WSE has promising anxiolytic and anti-inflammatory activities.
Titel: |
In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds.
|
---|---|
Autor/in / Beteiligte Person: | Babar, ZM ; Jaswir, I ; Tareq, AM ; Ali Reza, ASM ; Azizi, WM ; Hafidz, M ; Ahfter, F ; Hasan, M ; Farhad, S ; Uddin, MMR ; Ichwan, SJ ; Ahmed, QU ; Taher, M ; Mawa, I |
Link: | |
Zeitschrift: | Natural product research, Jg. 35 (2021-08-01), Heft 16, S. 2793 |
Veröffentlichung: | Milton Park, UK : Taylor & Francis Health Sciences, c2003-, 2021 |
Medientyp: | academicJournal |
ISSN: | 1478-6427 (electronic) |
DOI: | 10.1080/14786419.2019.1667348 |
Schlagwort: |
|
Sonstiges: |
|