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Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.

Titel:	VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy.
Autor/in / Beteiligte Person:	Fonseca, AM ; González, R ; Bardají, A ; Jairoce, C ; Rupérez, M ; Jiménez, A ; Quintó, L ; Cisteró, P ; Vala, A ; Sacoor, C ; Gupta, H ; Hegewisch-Taylor, J ; Brew, J ; Ndam, NT ; Kariuki, S ; López, M ; Dobaño, C ; Chitnis, CE ; Ouma, P ; Ramharter, M ; Abdulla, S ; Aponte, JJ ; Massougbodji, A ; Briand, V ; Mombo-Ngoma, G ; Desai, M ; Cot, M ; Nhacolo, A ; Sevene, E ; Macete, E ; Menéndez, C ; Mayor, A
Link:	Zum Volltext
Zeitschrift:	Emerging infectious diseases, Jg. 25 (2019-10-01), Heft 10, S. 1851
Veröffentlichung:	Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-, 2019
Medientyp:	academicJournal
ISSN:	1080-6059 (electronic)
DOI:	10.3201/eid2510.181177
Schlagwort:	Adult Antibodies, Protozoan immunology Antigens, Protozoan immunology Benin epidemiology Female Gabon epidemiology Humans Immunoglobulin G immunology Kenya epidemiology Malaria, Falciparum diagnosis Malaria, Falciparum epidemiology Malaria, Falciparum transmission Mozambique epidemiology Plasmodium falciparum immunology Pregnancy Pregnancy Complications, Parasitic blood Pregnancy Complications, Parasitic diagnosis Serologic Tests methods Spain epidemiology Tanzania epidemiology Young Adult Antigens, Protozoan blood Malaria, Falciparum complications Pregnancy Complications, Parasitic epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Emerg Infect Dis] 2019 Oct; Vol. 25 (10), pp. 1851-1860. MeSH Terms: Antigens, Protozoan / blood ; Malaria, Falciparum / complications ; Pregnancy Complications, Parasitic / *epidemiology ; Adult ; Antibodies, Protozoan / immunology ; Antigens, Protozoan / immunology ; Benin / epidemiology ; Female ; Gabon / epidemiology ; Humans ; Immunoglobulin G / immunology ; Kenya / epidemiology ; Malaria, Falciparum / diagnosis ; Malaria, Falciparum / epidemiology ; Malaria, Falciparum / transmission ; Mozambique / epidemiology ; Plasmodium falciparum / immunology ; Pregnancy ; Pregnancy Complications, Parasitic / blood ; Pregnancy Complications, Parasitic / diagnosis ; Serologic Tests / methods ; Spain / epidemiology ; Tanzania / epidemiology ; Young Adult References: PLoS Med. 2010 Jul 06;7(7):e1000304. (PMID: 20625549) ; PLoS One. 2015 Sep 22;10(9):e0137695. (PMID: 26393516) ; J Infect Dis. 2012 Nov 15;206(10):1612-21. (PMID: 22966126) ; J Immunol Res. 2015;2015:738030. (PMID: 26770994) ; Science. 1996 Jun 7;272(5267):1502-4. (PMID: 8633247) ; PLoS One. 2012;7(1):e29874. (PMID: 22299027) ; PLoS Pathog. 2008 Feb 8;4(2):e42. (PMID: 18282103) ; BMC Med. 2017 Jul 17;15(1):130. (PMID: 28712360) ; Placenta. 2004 May;25(5):359-78. (PMID: 15081631) ; BMC Med. 2017 Jun 30;15(1):121. (PMID: 28662646) ; Malar J. 2016 Jul 29;15(1):392. (PMID: 27473039) ; PLoS Med. 2014 Sep 23;11(9):e1001735. (PMID: 25247995) ; Sci Rep. 2014 Dec 09;4:7373. (PMID: 25487735) ; PLoS One. 2017 Jul 17;12(7):e0181150. (PMID: 28715465) ; PLoS One. 2008 Apr 09;3(4):e1934. (PMID: 18398460) ; Clin Vaccine Immunol. 2008 Sep;15(9):1483-4. (PMID: 18632926) ; J Infect Dis. 2012 Feb 15;205(4):568-77. (PMID: 22238468) ; Adv Parasitol. 2009;69:299-352. (PMID: 19622411) ; Trends Parasitol. 2014 Feb;30(2):85-94. (PMID: 24388420) ; Mol Microbiol. 2003 Jul;49(1):179-91. (PMID: 12823820) ; J Infect Dis. 2010 Jan 1;201(1):123-31. (PMID: 19954383) ; J Infect Dis. 2013 Jun 1;207(11):1664-74. (PMID: 23448726) ; Am J Trop Med Hyg. 2007 Mar;76(3):522-7. (PMID: 17360878) ; Nature. 2015 Oct 8;526(7572):207-211. (PMID: 26375008) ; N Engl J Med. 2015 Oct 22;373(17):1607-17. (PMID: 26488692) ; Ann Trop Med Parasitol. 1949 Oct;43(2):117-39. (PMID: 15393585) ; Lancet Glob Health. 2015 Oct;3(10):e617-28. (PMID: 26296450) ; PLoS Med. 2014 Sep 23;11(9):e1001733. (PMID: 25247709) ; Mol Biochem Parasitol. 2007 Oct;155(2):103-12. (PMID: 17669514) Contributed Indexing: Keywords: Benin; Gabon; Kenya; Malaria; Mozambique; Plasmodium falciparum; Spain; Tanzania; VAR2CSA; exposure; immunity; parasites; pregnancy; serology; transmission Substance Nomenclature: 0 (Antibodies, Protozoan) ; 0 (Antigens, Protozoan) ; 0 (Immunoglobulin G) ; 0 (VAR2CSA protein, Plasmodium falciparum) Entry Date(s): Date Created: 20190921 Date Completed: 20200714 Latest Revision: 20220128 Update Code: 20240513 PubMed Central ID: PMC6759269

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VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy.