Comparison of Fluorine(18)-fluorodeoxyglucose and Gallium(68)-citrate PET/CT in patients with tuberculosis.
In: Nuklearmedizin. Nuclear medicine, Jg. 58 (2019-09-01), Heft 5, S. 371
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Zugriff:
18 F-FDG and 68 Ga-citrate PET/CT have both been shown to be useful in the management of tuberculosis (TB). We compared the abnormal PET findings of 18 F-FDG- and 68 Ga-citrate-PET/CT in patients with TB.
Methods: Patients with TB on anti-TB therapy were included. Patients had a set of PET scans consisting of both 18 F-FDG and 68 Ga-citrate. Abnormal lesions were identified, and the two sets of scans were compared. The scan findings were correlated to the clinical data as provided by the attending physician.
Results: 46 PET/CT scans were performed in 18 patients, 11 (61 %) were female, and the mean age was 35.7 ± 13.5 years. Five patients also had both studies for follow-up reasons during the use of anti-TB therapy. Thirteen patients were co-infected with HIV. 18 F-FDG detected more lesions than 68 Ga-citrate (261 vs. 166, p < 0.0001). 68 Ga-citrate showed a better definition of intracerebral lesions due to the absence of tracer uptake in the brain. The mean SUVmax was higher for 18 F-FDG compared to 68 Ga-citrate (5.73 vs. 3.01, p < 0.0001). We found a significant correlation between the SUVmax of lesions that were determined by both tracers (r = 0.4968, p < 0.0001).
Conclusion: Preliminary data shows 18 F-FDG-PET detects more abnormal lesions in TB compared to 68 Ga-citrate. However, 68 Ga-citrate has better lesion definition in the brain and is therefore especially useful when intracranial TB is suspected.
Competing Interests: The authors declare there is no conflict of interest.
(© Georg Thieme Verlag KG Stuttgart · New York.)
Titel: |
Comparison of Fluorine(18)-fluorodeoxyglucose and Gallium(68)-citrate PET/CT in patients with tuberculosis.
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Autor/in / Beteiligte Person: | Ankrah, AO ; Lawal, IO ; Boshomane, TMG ; Klein, HC ; Ebenhan, T ; Dierckx, RAJO ; Vorster, M ; Glaudemans, AWJM ; Sathekge, MM |
Zeitschrift: | Nuklearmedizin. Nuclear medicine, Jg. 58 (2019-09-01), Heft 5, S. 371 |
Veröffentlichung: | 2018- : Stuttgart : Thieme ; <i>Original Publication</i>: Stuttgart, F.K. Schattauer., 2019 |
Medientyp: | academicJournal |
ISSN: | 2567-6407 (electronic) |
DOI: | 10.1055/a-1000-6951 |
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