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The protective effect of icariin and phosphorylated icariin against LPS-induced intestinal goblet cell dysfunction.

Xiong, W ; Ma, H ; et al.
In: Innate immunity, Jg. 26 (2020-02-01), Heft 2, S. 97-106
Online academicJournal
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Titel:
The protective effect of icariin and phosphorylated icariin against LPS-induced intestinal goblet cell dysfunction.
Autor/in / Beteiligte Person: Xiong, W ; Ma, H ; Zhang, Z ; Jin, M ; Wang, J ; Xu, Y ; Wang, Z
Link:
Zeitschrift: Innate immunity, Jg. 26 (2020-02-01), Heft 2, S. 97-106
Veröffentlichung: Los Angeles : Sage Publications, c2008-, 2020
Medientyp: academicJournal
ISSN: 1753-4267 (electronic)
DOI: 10.1177/1753425919867746
Schlagwort:
  • Apoptosis genetics
  • Caspase 3 genetics
  • Caspase 3 metabolism
  • Caspases, Initiator genetics
  • Caspases, Initiator metabolism
  • Catalase metabolism
  • Cell Survival drug effects
  • Endoplasmic Reticulum Chaperone BiP
  • Flavonoids metabolism
  • Glutathione Peroxidase metabolism
  • Goblet Cells enzymology
  • Goblet Cells metabolism
  • Heat-Shock Proteins genetics
  • Heat-Shock Proteins metabolism
  • Humans
  • Hydrogen Peroxide metabolism
  • Inflammation genetics
  • Interleukin-1beta metabolism
  • Interleukin-6 metabolism
  • Interleukin-8 metabolism
  • L-Lactate Dehydrogenase metabolism
  • Lipopolysaccharides pharmacology
  • Malondialdehyde metabolism
  • Mucin-2 biosynthesis
  • Mucin-2 metabolism
  • Phosphorylation
  • Reactive Oxygen Species metabolism
  • Superoxide Dismutase-1 metabolism
  • Transcription Factor CHOP genetics
  • Transcription Factor CHOP metabolism
  • Tumor Necrosis Factor-alpha metabolism
  • X-Box Binding Protein 1 genetics
  • X-Box Binding Protein 1 metabolism
  • Apoptosis drug effects
  • Cell Proliferation drug effects
  • Flavonoids pharmacology
  • Goblet Cells drug effects
  • Inflammation metabolism
Sonstiges:
  • Nachgewiesen in: MEDLINE
  • Sprachen: English
  • Publication Type: Journal Article; Research Support, Non-U.S. Gov't
  • Language: English
  • [Innate Immun] 2020 Feb; Vol. 26 (2), pp. 97-106. <i>Date of Electronic Publication: </i>2019 Aug 07.
  • MeSH Terms: Apoptosis / *drug effects ; Cell Proliferation / *drug effects ; Flavonoids / *pharmacology ; Goblet Cells / *drug effects ; Inflammation / *metabolism ; Apoptosis / genetics ; Caspase 3 / genetics ; Caspase 3 / metabolism ; Caspases, Initiator / genetics ; Caspases, Initiator / metabolism ; Catalase / metabolism ; Cell Survival / drug effects ; Endoplasmic Reticulum Chaperone BiP ; Flavonoids / metabolism ; Glutathione Peroxidase / metabolism ; Goblet Cells / enzymology ; Goblet Cells / metabolism ; Heat-Shock Proteins / genetics ; Heat-Shock Proteins / metabolism ; Humans ; Hydrogen Peroxide / metabolism ; Inflammation / genetics ; Interleukin-1beta / metabolism ; Interleukin-6 / metabolism ; Interleukin-8 / metabolism ; L-Lactate Dehydrogenase / metabolism ; Lipopolysaccharides / pharmacology ; Malondialdehyde / metabolism ; Mucin-2 / biosynthesis ; Mucin-2 / metabolism ; Phosphorylation ; Reactive Oxygen Species / metabolism ; Superoxide Dismutase-1 / metabolism ; Transcription Factor CHOP / genetics ; Transcription Factor CHOP / metabolism ; Tumor Necrosis Factor-alpha / metabolism ; X-Box Binding Protein 1 / genetics ; X-Box Binding Protein 1 / metabolism
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  • Contributed Indexing: Keywords: Icariin; LPS; LS174T cells; mucus barrier; phosphorylated icariin
  • Substance Nomenclature: 0 (DDIT3 protein, human) ; 0 (Endoplasmic Reticulum Chaperone BiP) ; 0 (Flavonoids) ; 0 (Heat-Shock Proteins) ; 0 (Interleukin-1beta) ; 0 (Interleukin-6) ; 0 (Interleukin-8) ; 0 (Lipopolysaccharides) ; 0 (Mucin-2) ; 0 (Reactive Oxygen Species) ; 0 (Tumor Necrosis Factor-alpha) ; 0 (X-Box Binding Protein 1) ; 0 (XBP1 protein, human) ; 147336-12-7 (Transcription Factor CHOP) ; 4Y8F71G49Q (Malondialdehyde) ; BBX060AN9V (Hydrogen Peroxide) ; EC 1.1.1.27 (L-Lactate Dehydrogenase) ; EC 1.11.1.6 (Catalase) ; EC 1.11.1.9 (Glutathione Peroxidase) ; EC 1.15.1.1 (Superoxide Dismutase-1) ; EC 3.4.22.- (CASP4 protein, human) ; EC 3.4.22.- (Caspase 3) ; EC 3.4.22.- (Caspases, Initiator) ; VNM47R2QSQ (icariin)
  • Entry Date(s): Date Created: 20190809 Date Completed: 20201204 Latest Revision: 20211204
  • Update Code: 20231215
  • PubMed Central ID: PMC7016409

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