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Background: Prenatal stress (PS) leads to a wide variety of behavioral and emotional aberration observed in later life, particularly in the impairment of spatial learning and memory in offspring. Icariin (ICA) is a naturally occurring furanocoumarin and exhibits many pharmacological properties, including potent improvement on learning and memory.

Purpose: We pretend to investigate the improvement of ICA on learning and memory impairment in PS.

Methods: Female PS offspring rats were used to explore the effects of ICA on learning and memory impairment. After 28 days of ICA (20, 40 and 80 mg/kg/day) treatment, we measured Morris water maze and 8-Arm Maze, the HPA axis and the related pathway in the hippocampus.

Results: We reported that ICA ameliorated the spatial learning and memory and working memory impairment in the female offspring rats. Correspondingly, ICA prevented adverse changes in the dendritic morphology of CA3 pyramidal neurons in the hippocampus. ICA significantly decreased the serum adrenocorticotropin, corticotropin-releasing hormone and corticosterone levels in offspring rats exposed to PS, associated with increased GR expression. Additionally, ICA treatment significantly increased the neurogranin (Ng) and c-fos protein expression of hippocampus in the offspring rats. Furthermore, the protein of relative content of p-EKR/ERK, p-CaMKIIα/CaMKIIα, p-CREB/CREB were remarkably increased after ICA treatment in the offspring rats.

Conclusion: Taken together, ICA may be an effective therapeutic for learning and memory dysfunction in female offspring exposed to PS, its neuroprotective effect was mediated in part by normalizing the HPA axis and up-regulating of ERK/CaMKIIα/CREB signaling, Ng and c-fos protein.

Titel:	Icariin ameliorates learning and memory impairments through ERK/CaMKIIα/CREB signaling and HPA axis in prenatally stressed female offspring.
Autor/in / Beteiligte Person:	Zheng, XX ; Chen, YW ; Yue, YS ; Li, YC ; Xia, SZ ; Li, Y ; Deng, HH ; He, J ; Cao, YJ
Link:	Zum Volltext
Zeitschrift:	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Jg. 117 (2019-09-01), S. 109077
Veröffentlichung:	Paris : Editions Scientifiques Elsevier ; <i>Original Publication</i>: New York, N.Y. : Masson Pub. USA, Inc., c1982-, 2019
Medientyp:	academicJournal
ISSN:	1950-6007 (electronic)
DOI:	10.1016/j.biopha.2019.109077
Schlagwort:	Animals Calcium-Calmodulin-Dependent Protein Kinase Kinase metabolism Cyclic AMP Response Element-Binding Protein metabolism Disease Models, Animal Female Hippocampus drug effects Hippocampus metabolism Hypothalamo-Hypophyseal System metabolism MAP Kinase Signaling System drug effects Male Maze Learning drug effects Memory drug effects Memory Disorders metabolism Pituitary-Adrenal System metabolism Pregnancy Prenatal Exposure Delayed Effects drug therapy Prenatal Exposure Delayed Effects metabolism Pyramidal Cells drug effects Pyramidal Cells metabolism Rats Rats, Sprague-Dawley Stress, Psychological metabolism Flavonoids pharmacology Hypothalamo-Hypophyseal System drug effects Memory Disorders drug therapy Pituitary-Adrenal System drug effects Signal Transduction drug effects Spatial Learning drug effects Stress, Psychological drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Biomed Pharmacother] 2019 Sep; Vol. 117, pp. 109077. <i>Date of Electronic Publication: </i>2019 Jun 06. MeSH Terms: Flavonoids / pharmacology ; Hypothalamo-Hypophyseal System / drug effects ; Memory Disorders / drug therapy ; Pituitary-Adrenal System / drug effects ; Signal Transduction / drug effects ; Spatial Learning / drug effects ; Stress, Psychological / *drug therapy ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Kinase / metabolism ; Cyclic AMP Response Element-Binding Protein / metabolism ; Disease Models, Animal ; Female ; Hippocampus / drug effects ; Hippocampus / metabolism ; Hypothalamo-Hypophyseal System / metabolism ; MAP Kinase Signaling System / drug effects ; Male ; Maze Learning / drug effects ; Memory / drug effects ; Memory Disorders / metabolism ; Pituitary-Adrenal System / metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects / drug therapy ; Prenatal Exposure Delayed Effects / metabolism ; Pyramidal Cells / drug effects ; Pyramidal Cells / metabolism ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological / metabolism Contributed Indexing: Keywords: CREB; HPA axis; Icariin; Learning and memory; Prenatal stress Substance Nomenclature: 0 (CREB1 protein, human) ; 0 (Cyclic AMP Response Element-Binding Protein) ; 0 (Flavonoids) ; EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Kinase) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20190610 Date Completed: 20200108 Latest Revision: 20200108 Update Code: 20240513

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Icariin ameliorates learning and memory impairments through ERK/CaMKIIα/CREB signaling and HPA axis in prenatally stressed female offspring.