Significance and Role of Pattern Recognition Receptors in Malignancy.
In: Archivum immunologiae et therapiae experimentalis, Jg. 67 (2019-06-01), Heft 3, S. 133-141
academicJournal
Zugriff:
Pattern recognition receptors (PRRs) are members of innate immunity, playing pivotal role in several immunological reactions. They are known to act as a bridge between innate and adaptive immunity. They are expressed on several normal cell types but have been shown with increasing frequency on/in tumor cells. Significance of this phenomenon is largely unknown, but it has been shown by several authors that they, predominantly Toll-like receptors (TLRs), act in the interest of tumor, by promotion of its growth and spreading. Preparation of artificial of TLRs ligands (agonists) paved the way to use them as a therapeutic agents for cancer, so far in a limited scale. Agonists may be combined with conventional anti-cancer modalities with apparently promising results. PRRs recognizing nucleic acids such as RIG-1 like receptors (sensing RNA) and STING (sensing DNA) constitute a novel promising approach for cancer immunotherapy.
Titel: |
Significance and Role of Pattern Recognition Receptors in Malignancy.
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Autor/in / Beteiligte Person: | Żeromski, J ; Kaczmarek, M ; Boruczkowski, M ; Kierepa, A ; Kowala-Piaskowska, A ; Mozer-Lisewska, I |
Zeitschrift: | Archivum immunologiae et therapiae experimentalis, Jg. 67 (2019-06-01), Heft 3, S. 133-141 |
Veröffentlichung: | 2024- : Warsaw, Poland : Sciendo ; <i>Original Publication</i>: Warszawa, Panstwowy Zakład Wydawn. Lekarskich., 2019 |
Medientyp: | academicJournal |
ISSN: | 1661-4917 (electronic) |
DOI: | 10.1007/s00005-019-00540-x |
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