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Background: Historically, the major cause of meningococcal epidemics in the meningitis belt of sub-Saharan Africa has been Neisseria meningitidis serogroup A (NmA), but the incidence has been substantially reduced since the introduction of a serogroup A conjugate vaccine starting in 2010. We performed whole-genome sequencing on isolates collected post-2010 to assess their phylogenetic relationships and inter-country transmission.

Methods: A total of 716 invasive meningococcal isolates collected between 2011 and 2016 from 11 meningitis belt countries were whole-genome sequenced for molecular characterization by the three WHO Collaborating Centers for Meningitis.

Findings: We identified three previously-reported clonal complexes (CC): CC11 (n = 434), CC181 (n = 62) and CC5 (n = 90) primarily associated with NmW, NmX, and NmA, respectively, and an emerging CC10217 (n = 126) associated with NmC. CC11 expanded throughout the meningitis belt independent of the 2000 Hajj outbreak strain, with isolates from Central African countries forming a distinct sub-lineage within this expansion. Two major sub-lineages were identified for CC181 isolates, one mainly expanding in West African countries and the other found in Chad. CC10217 isolates from the large outbreaks in Nigeria and Niger were more closely related than those from the few cases in Mali and Burkina Faso.

Interpretations: Whole-genome based phylogenies revealed geographically distinct strain circulation as well as inter-country transmission events. Our results stress the importance of continued meningococcal molecular surveillance in the region, as well as the development of an affordable vaccine targeting these strains. FUND: Meningitis Research Foundation; CDC's Office of Advanced Molecular Detection; GAVI, the Vaccine Alliance.

Titel:	Phylogenetic relationships and regional spread of meningococcal strains in the meningitis belt, 2011-2016.
Autor/in / Beteiligte Person:	Topaz, N ; Caugant, DA ; Taha, MK ; Brynildsrud, OB ; Debech, N ; Hong, E ; Deghmane, AE ; Ouédraogo, R ; Ousmane, S ; Gamougame, K ; Njanpop-Lafourcade, BM ; Diarra, S ; Fox, LM ; Wang, X
Link:	Zum Volltext
Zeitschrift:	EBioMedicine, Jg. 41 (2019-03-01), S. 488
Veröffentlichung:	[Amsterdam] : Elsevier B.V., [2014]-, 2019
Medientyp:	academicJournal
ISSN:	2352-3964 (electronic)
DOI:	10.1016/j.ebiom.2019.02.054
Schlagwort:	Africa epidemiology DNA, Bacterial chemistry DNA, Bacterial isolation & purification DNA, Bacterial metabolism Humans Meningitis, Meningococcal epidemiology Meningitis, Meningococcal microbiology Neisseria meningitidis genetics Neisseria meningitidis isolation & purification Phylogeny Whole Genome Sequencing Meningitis, Meningococcal diagnosis Neisseria meningitidis classification
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [EBioMedicine] 2019 Mar; Vol. 41, pp. 488-496. <i>Date of Electronic Publication: </i>2019 Mar 04. MeSH Terms: Meningitis, Meningococcal / diagnosis ; Neisseria meningitidis / classification ; Africa / epidemiology ; DNA, Bacterial / chemistry ; DNA, Bacterial / isolation & purification ; DNA, Bacterial / metabolism ; Humans ; Meningitis, Meningococcal / epidemiology ; Meningitis, Meningococcal / microbiology ; Neisseria meningitidis / genetics ; Neisseria meningitidis / isolation & purification ; Phylogeny ; Whole Genome Sequencing Comments: Comment in: EBioMedicine. 2019 Apr;42:34-35. (PMID: 30935890) ; Erratum in: EBioMedicine. 2020 Jan;51:102564. (PMID: 31901871) References: Clin Infect Dis. 2007 Mar 1;44(5):657-63. (PMID: 17278055) ; Vaccine. 2007 Sep 3;25 Suppl 1:A97-100. (PMID: 17521780) ; Vaccine. 2010 Aug 23;28(37):6086-93. (PMID: 20619376) ; BMC Bioinformatics. 2010 Dec 10;11:595. (PMID: 21143983) ; PLoS One. 2011;6(5):e19513. (PMID: 21625480) ; Mol Biol Evol. 2012 Aug;29(8):1969-73. (PMID: 22367748) ; J Comput Biol. 2012 May;19(5):455-77. (PMID: 22506599) ; Lancet Infect Dis. 2012 Oct;12(10):757-64. (PMID: 22818241) ; PLoS One. 2012;7(9):e46019. (PMID: 23029368) ; Vaccine. 2013 Feb 4;31(7):1113-6. (PMID: 23261039) ; Wkly Epidemiol Rec. 2013 Mar 22;88(12):129-36. (PMID: 23544241) ; Nat Methods. 2013 Jun;10(6):563-9. (PMID: 23644548) ; Bioinformatics. 2014 May 1;30(9):1312-3. (PMID: 24451623) ; Emerg Infect Dis. 2014 Mar;20(3):394-9. (PMID: 24571805) ; MBio. 2014 Oct 21;5(5):e01974-14. (PMID: 25336458) ; Genome Biol. 2014;15(11):524. (PMID: 25410596) ; Nucleic Acids Res. 2015 Feb 18;43(3):e15. (PMID: 25414349) ; PLoS Curr. 2014 Dec 29;6:null. (PMID: 25685621) ; J Infect. 2015 Nov;71(5):544-52. (PMID: 26226598) ; Clin Infect Dis. 2015 Nov 15;61 Suppl 5:S434-41. (PMID: 26553672) ; Emerg Infect Dis. 2016 Apr;22(4):698-702. (PMID: 26982628) ; Emerg Infect Dis. 2016 Oct;22(10):1762-1768. (PMID: 27649262) ; mSphere. 2016 Nov 16;1(6):. (PMID: 27904879) ; Proc Natl Acad Sci U S A. 2018 May 22;115(21):5510-5515. (PMID: 29735685) ; Bull World Health Organ. 1983;61(2):325-30. (PMID: 6345014) Contributed Indexing: Keywords: Invasive meningococcal disease; Meningitis; Meningitis belt; Neisseria meningitidis; Phylogenetics Substance Nomenclature: 0 (DNA, Bacterial) Entry Date(s): Date Created: 20190309 Date Completed: 20190712 Latest Revision: 20200225 Update Code: 20231215 PubMed Central ID: PMC6443582

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Phylogenetic relationships and regional spread of meningococcal strains in the meningitis belt, 2011-2016.