[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-β Load in Subjects Examined for Normal Pressure Hydrocephalus.
In: Journal of Alzheimer's disease : JAD, Jg. 67 (2019), Heft 4, S. 1343
academicJournal
Zugriff:
Background: Idiopathic normal pressure hydrocephalus (iNPH) is frequently associated with concomitant amyloid-β (Aβ) pathology.
Objective: To compare the [11C]PIB PET uptake in the patients with suspected iNPH to Aβ and hyperphosphorylated-tau (HPτ) in the right frontal cortical biopsy, the cerebrospinal fluid (CSF) Aβ, the response to a CSF shunt, and the final clinical diagnosis of Alzheimer's disease (AD).
Methods: Patients (n = 21) from Kuopio NPH Registry (http://www.uef.fi/nph) with intraventricular pressure monitoring, immunostaining for Aβ and HPτ in the right frontal cortical biopsies, and a Mini-Mental State Examination and a Clinical Dementia Rating underwent [11C]PIB PET. Aβ, total tau, and Pτ181 were measured by ELISA from the ventricular (n = 15) and the lumbar (n = 9) CSF. Response to the shunt was seen in 13 out of the 15 shunted patients. AD was diagnosed in 8 patients during a median follow-up of 6 years (mean 7.3±2.4 years, range 3-1).
Results: [11C]PIB uptake in the right frontal cortex (ρ= 0.60, p < 0.01) and the combined neocortical [11C]PIB uptake score (ρ= 0.61, p < 0.01) were associated with a higher Aβ load in the right frontal cortical biopsy. Excluding one (1/15) outlier, [11C]PIB uptake was also associated with the ventricular CSF Aβ (ρ= -0.58, p = 0.03).
Conclusions: The findings show that [11C]PIB PET can reliably detect simultaneous amyloid pathology among the iNPH patients. Further studies will show whether amyloid PET could predict a clinical response to the shunt operation. In addition, the presence of Aβ pathology in the patients with iNPH might also warrant treatment with current AD drugs.
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[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-β Load in Subjects Examined for Normal Pressure Hydrocephalus.
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Autor/in / Beteiligte Person: | Rinne, JO ; Suotunen, T ; Rummukainen, J ; Herukka, SK ; Nerg, O ; Koivisto, AM ; Rauramaa, T ; Någren, K ; Hiltunen, M ; Alafuzoff, I ; Rinne, J ; Jääskeläinen, JE ; Soininen, H ; Leinonen, V |
Zeitschrift: | Journal of Alzheimer's disease : JAD, Jg. 67 (2019), Heft 4, S. 1343 |
Veröffentlichung: | Amsterdam ; Washington : IOS Press, c1998-, 2019 |
Medientyp: | academicJournal |
ISSN: | 1875-8908 (electronic) |
DOI: | 10.3233/JAD-180645 |
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