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In Alzheimer's Disease (AD) dual-tracer positron emission tomography (PET) studies with 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) and 11C-labelled Pittsburgh Compound B (PIB) are used to assess metabolism and cerebral amyloid-β deposition, respectively. Regional cerebral metabolism and blood flow (rCBF) are closely coupled, both providing an index for neuronal function. The present study compared PIB-derived rCBF, estimated by the ratio of tracer influx in target regions relative to reference region (R1) and early-stage PIB uptake (ePIB), to FDG scans. Fifteen PIB positive (+) patients and fifteen PIB negative (-) subjects underwent both FDG and PIB PET scans to assess the use of R1 and ePIB as a surrogate for FDG. First, subjects were classified based on visual inspection of the PIB PET images. Then, discriminative performance (PIB+ versus PIB-) of rCBF methods were compared to normalized regional FDG uptake. Strong positive correlations were found between analyses, suggesting that PIB-derived rCBF provides information that is closely related to what can be seen on FDG scans. Yet group related differences between method's distributions were seen as well. Also, a better correlation with FDG was found for R1 than for ePIB. Further studies are needed to validate the use of R1 as an alternative for FDG studies in clinical applications.

Competing Interests: The authors have declared that no competing interests exist.

Titel:	Relative cerebral flow from dynamic PIB scans as an alternative for FDG scans in Alzheimer's disease PET studies.
Autor/in / Beteiligte Person:	Peretti, DE ; Vállez García, D ; Reesink, FE ; van der Goot T ; De Deyn, PP ; de Jong BM ; Dierckx, RAJO ; Boellaard, R
Link:	Zum Volltext
Zeitschrift:	PloS one, Jg. 14 (2019-01-17), Heft 1, S. e0211000
Veröffentlichung:	San Francisco, CA : Public Library of Science, 2019
Medientyp:	academicJournal
ISSN:	1932-6203 (electronic)
DOI:	10.1371/journal.pone.0211000
Schlagwort:	Aged Aniline Compounds pharmacokinetics Brain metabolism Carbon Radioisotopes pharmacokinetics Case-Control Studies Cognitive Dysfunction diagnostic imaging Cognitive Dysfunction physiopathology Female Fluorine Radioisotopes pharmacokinetics Fluorodeoxyglucose F18 pharmacokinetics Glucose metabolism Humans Male Middle Aged Positron-Emission Tomography statistics & numerical data Radiopharmaceuticals pharmacokinetics Thiazoles pharmacokinetics Alzheimer Disease diagnostic imaging Alzheimer Disease physiopathology Brain blood supply Brain diagnostic imaging Cerebrovascular Circulation physiology Positron-Emission Tomography methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [PLoS One] 2019 Jan 17; Vol. 14 (1), pp. e0211000. <i>Date of Electronic Publication: </i>2019 Jan 17 (<i>Print Publication: </i>2019). MeSH Terms: Alzheimer Disease / diagnostic imaging ; Alzheimer Disease / physiopathology ; Brain / blood supply ; Brain / diagnostic imaging ; Cerebrovascular Circulation / physiology ; Positron-Emission Tomography / methods ; Aged ; Aniline Compounds / pharmacokinetics ; Brain / metabolism ; Carbon Radioisotopes / pharmacokinetics ; Case-Control Studies ; Cognitive Dysfunction / diagnostic imaging ; Cognitive Dysfunction / physiopathology ; Female ; Fluorine Radioisotopes / pharmacokinetics ; Fluorodeoxyglucose F18 / pharmacokinetics ; Glucose / metabolism ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography / statistics & numerical data ; Radiopharmaceuticals / pharmacokinetics ; Thiazoles / pharmacokinetics Comments: Erratum in: PLoS One. 2019 Mar 18;14(3):e0214187. (PMID: 30883613) References: J Nucl Med. 2011 Feb;52(2):173-9. (PMID: 21233181) ; Neuroimage. 2014 May 15;92:225-36. (PMID: 24361666) ; J Cereb Blood Flow Metab. 2002 Dec;22(12):1440-52. (PMID: 12468889) ; J Nucl Med. 2016 Jul;57(7):1071-7. (PMID: 26912447) ; J Nucl Med. 2011 Mar;52(3):393-400. (PMID: 21321269) ; Eur J Nucl Med Mol Imaging. 2005 Apr;32(4):486-510. (PMID: 15747152) ; Nat Rev Neurol. 2010 Feb;6(2):78-87. (PMID: 20139997) ; Lancet Neurol. 2015 Oct;14(10):1037-53. (PMID: 26318837) ; Neuroimage. 2007 Jun;36(2):298-312. (PMID: 17449282) ; Alzheimers Dement. 2011 May;7(3):263-9. (PMID: 21514250) ; J Alzheimers Dis. 2015;44(3):815-26. (PMID: 25362041) ; Open Neuroimag J. 2008 Nov 13;2:114-25. (PMID: 19526073) ; Eur J Nucl Med Mol Imaging. 2012 Apr;39(4):613-20. (PMID: 22270508) ; Hum Brain Mapp. 2003 Aug;19(4):224-47. (PMID: 12874777) ; Eur J Nucl Med Mol Imaging. 2013 Jun;40(6):908-20. (PMID: 23412134) ; J Cereb Blood Flow Metab. 2010 Jan;30(1):2-14. (PMID: 19738630) ; Neurology. 2008 Sep 16;71(12):903-10. (PMID: 18794492) ; Neuroimage Clin. 2016 Oct 08;14:77-86. (PMID: 28138429) ; Neurobiol Aging. 2009 Dec;30(12):1902-9. (PMID: 18346821) ; Neuroimage. 2008 Aug 1;42(1):76-86. (PMID: 18541442) ; Neuroimage. 1995 Jun;2(2):148-56. (PMID: 9343597) ; Acta Neuropathol. 1989;77(3):314-9. (PMID: 2466390) ; Nat Rev Neurosci. 2004 May;5(5):347-60. (PMID: 15100718) ; Mov Disord. 2010 Oct 30;25(14):2395-404. (PMID: 20669302) ; J Cereb Blood Flow Metab. 2017 Feb;37(2):740-749. (PMID: 27107028) ; Eur J Nucl Med Mol Imaging. 2016 Aug;43(9):1700-9. (PMID: 27026271) ; Neuroimage. 2016 May 15;132:334-343. (PMID: 26915497) ; Neurology. 2007 Aug 28;69(9):871-7. (PMID: 17724289) ; Cereb Cortex. 2009 Feb;19(2):375-82. (PMID: 18534991) ; Cell Metab. 2011 Dec 7;14(6):724-38. (PMID: 22152301) ; Stat Med. 2008 Feb 28;27(5):778-80. (PMID: 17907247) ; Am J Pathol. 1989 Aug;135(2):309-19. (PMID: 2675616) ; Ann Neurol. 1997 Jul;42(1):85-94. (PMID: 9225689) ; Lancet Neurol. 2010 Jan;9(1):119-28. (PMID: 20083042) ; Neurology. 2007 May 15;68(20):1718-25. (PMID: 17502554) ; J Nucl Med. 1998 May;39(5):904-11. (PMID: 9591599) ; Arch Neurol. 2001 Dec;58(12):1985-92. (PMID: 11735772) ; J Nucl Med. 2005 Dec;46(12):1959-72. (PMID: 16330558) ; Neuroimage. 1996 Dec;4(3 Pt 1):153-8. (PMID: 9345505) ; J Cereb Blood Flow Metab. 2005 Nov;25(11):1528-47. (PMID: 15944649) ; J Nucl Med. 2015 Aug;56(8):1199-205. (PMID: 26045309) ; Neuroimage. 2005 Jul 1;26(3):839-51. (PMID: 15955494) ; Biochim Biophys Acta. 2012 Mar;1822(3):380-5. (PMID: 22115832) ; Ann Neurol. 2004 Mar;55(3):306-19. (PMID: 14991808) Substance Nomenclature: 0 (2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole) ; 0 (Aniline Compounds) ; 0 (Carbon Radioisotopes) ; 0 (Carbon-11) ; 0 (Fluorine Radioisotopes) ; 0 (Radiopharmaceuticals) ; 0 (Thiazoles) ; 0Z5B2CJX4D (Fluorodeoxyglucose F18) ; GZ5I74KB8G (Fluorine-18) ; IY9XDZ35W2 (Glucose) Entry Date(s): Date Created: 20190118 Date Completed: 20191029 Latest Revision: 20200309 Update Code: 20231215 PubMed Central ID: PMC6336325

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Relative cerebral flow from dynamic PIB scans as an alternative for FDG scans in Alzheimer's disease PET studies.