[Risk factors for in-hospital mortality among adult patients infected with colistin-resistant carbapenemase producing Klebsiella pneumoniae: a retrospective cohort study].

Sanctis, G ; Ferraris, A ; et al.

In: Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, Jg. 35 (2018), Heft 3, S. 239

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Background: The emergence of colistin resistant carbapenemase-producing Klebsiella represents a therapeutic challenge and a worldwide problem.

Aim: To estimate the in-hospital mortality and identify the associated risk factors among patients with colistin-resistant carbapenemase-producing Klebsiella pneumoniae (KPC) that present with a clinical infection.

Methods: We carried a retrospective cohort study, including adult patients infected with colistin-resistant KPC hospitalized at a tertiary teaching hospital in Buenos Aires, Argentina during the year 2016. The main outcome was in-hospital mortality. We used generalized lineal models to evaluate potential predictors of mortality.

Results: 18 patients that developed a colistin-resistant KPC clinical infection were identified and included in the final analysis. In-hospital mortality in this cohort was 38.9%. The presence of bacteremia, acute renal injury at the time of diagnosis and septic shock were associated with the main outcome.

Conclusions: Infections due to colistin-resistant KPC among in-hospital patients was frequent and was associated with high mortality rate. In our cohort, both shock and acute kidney injury were associated with a higher likelihood of poor outcomes. Further studies are warranted to evaluate the role of these and others risk factors so as to aid in the early detection of high risk patients.

Titel:	[Risk factors for in-hospital mortality among adult patients infected with colistin-resistant carbapenemase producing Klebsiella pneumoniae: a retrospective cohort study].
Autor/in / Beteiligte Person:	Sanctis, G ; Ferraris, A ; Ducatenzeiler, L ; Benso, J ; Fernández-Otero, L ; Angriman, F
Zeitschrift:	Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, Jg. 35 (2018), Heft 3, S. 239
Veröffentlichung:	Santiago, Chile : Publicaciones Técnicas Mediterráneo, Ltda.,, 2018
Medientyp:	academicJournal
ISSN:	0717-6341 (electronic)
DOI:	10.4067/s0716-10182018000300239
Schlagwort:	Adult Argentina Drug Resistance, Bacterial Female Humans Klebsiella Infections drug therapy Klebsiella Infections enzymology Klebsiella Infections microbiology Male Middle Aged Retrospective Studies Risk Factors Anti-Bacterial Agents therapeutic use Bacterial Proteins metabolism Colistin Hospital Mortality Klebsiella Infections mortality Klebsiella pneumoniae drug effects beta-Lactamases metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Spanish; Castilian Transliterated Title: Factores predictores de mortalidad intrahospitalaria en pacientes adultos con infecciones por Klebsiella pneumoniae resistente a carbapenémicos y colistín: un estudio de cohorte retrospectivo. Publication Type: Journal Article Language: Spanish; Castilian [Rev Chilena Infectol] 2018; Vol. 35 (3), pp. 239-245. MeSH Terms: Colistin* ; Hospital Mortality* ; Anti-Bacterial Agents / therapeutic use ; Bacterial Proteins / metabolism ; Klebsiella Infections / mortality ; Klebsiella pneumoniae / drug effects ; beta-Lactamases / *metabolism ; Adult ; Argentina ; Drug Resistance, Bacterial ; Female ; Humans ; Klebsiella Infections / drug therapy ; Klebsiella Infections / enzymology ; Klebsiella Infections / microbiology ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors Substance Nomenclature: 0 (Anti-Bacterial Agents) ; 0 (Bacterial Proteins) ; EC 3.5.2.6 (beta-Lactamases) ; EC 3.5.2.6 (carbapenemase) ; Z67X93HJG1 (Colistin) Entry Date(s): Date Created: 20181212 Date Completed: 20190726 Latest Revision: 20190726 Update Code: 20240513

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