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The pleiotropic effects of the glutamate dehydrogenase (GDH) pathway in Saccharomyces cerevisiae.

Mara, P ; Fragiadakis, GS ; et al.
In: Microbial cell factories, Jg. 17 (2018-11-01), Heft 1, S. 170
Online academicJournal
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Ammonium assimilation is linked to fundamental cellular processes that include the synthesis of non-essential amino acids like glutamate and glutamine. In Saccharomyces cerevisiae glutamate can be synthesized from α-ketoglutarate and ammonium through the action of NADP-dependent glutamate dehydrogenases Gdh1 and Gdh3. Gdh1 and Gdh3 are evolutionarily adapted isoforms and cover the anabolic role of the GDH-pathway. Here, we review the role and function of the GDH pathway in glutamate metabolism and we discuss the additional contributions of the pathway in chromatin regulation, nitrogen catabolite repression, ROS-mediated apoptosis, iron deficiency and sphingolipid-dependent actin cytoskeleton modulation in S.cerevisiae. The pleiotropic effects of GDH pathway in yeast biology highlight the importance of glutamate homeostasis in vital cellular processes and reveal new features for conserved enzymes that were primarily characterized for their metabolic capacity. These newly described features constitute insights that can be utilized for challenges regarding genetic engineering of glutamate homeostasis and maintenance of redox balances, biosynthesis of important metabolites and production of organic substrates. We also conclude that the discussed  pleiotropic features intersect with basic metabolism and set a new background for further glutamate-dependent applied research of biotechnological interest.

Titel:
The pleiotropic effects of the glutamate dehydrogenase (GDH) pathway in Saccharomyces cerevisiae.
Autor/in / Beteiligte Person: Mara, P ; Fragiadakis, GS ; Gkountromichos, F ; Alexandraki, D
Link:
Zeitschrift: Microbial cell factories, Jg. 17 (2018-11-01), Heft 1, S. 170
Veröffentlichung: London : BioMed Central, [2002-, 2018
Medientyp: academicJournal
ISSN: 1475-2859 (electronic)
DOI: 10.1186/s12934-018-1018-4
Schlagwort:
  • Actin Cytoskeleton metabolism
  • Endocytosis
  • gamma-Aminobutyric Acid metabolism
  • Genetic Pleiotropy
  • Glutamate Dehydrogenase metabolism
  • Saccharomyces cerevisiae enzymology
Sonstiges:
  • Nachgewiesen in: MEDLINE
  • Sprachen: English
  • Publication Type: Journal Article; Review
  • Language: English
  • [Microb Cell Fact] 2018 Nov 01; Vol. 17 (1), pp. 170. <i>Date of Electronic Publication: </i>2018 Nov 01.
  • MeSH Terms: Genetic Pleiotropy* ; Glutamate Dehydrogenase / *metabolism ; Saccharomyces cerevisiae / *enzymology ; Actin Cytoskeleton / metabolism ; Endocytosis ; gamma-Aminobutyric Acid / metabolism
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  • Grant Information: 377226 European Social Fund
  • Contributed Indexing: Keywords: Ammonium assimilation; Chromatin regulation; GABA shunt; GDH1; GDH2; GDH3; Glutamate dehydrogenase; Nitrogen catabolite repression; ROS-mediated apoptosis; S. cerevisiae
  • Substance Nomenclature: 56-12-2 (gamma-Aminobutyric Acid) ; EC 1.4.1.2 (Glutamate Dehydrogenase)
  • Entry Date(s): Date Created: 20181103 Date Completed: 20190122 Latest Revision: 20240403
  • Update Code: 20240403
  • PubMed Central ID: PMC6211499

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