Icariin and icaritin recover UVB-induced photoaging by stimulating Nrf2/ARE and reducing AP-1 and NF-κB signaling pathways: a comparative study on UVB-irradiated human keratinocytes.
In: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, Jg. 17 (2018-10-10), Heft 10, S. 1396-1408
Online
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Zugriff:
Icariin (ICA) and icaritin (ICT) exhibit many pharmacological functions including anti-osteoporosis, anti-cardiovascular, and anti-cancer activities; however, there are few comprehensive studies that track the detailed effects on UVB-induced photoaging. The recovery effects of ICA and ICT were investigated in UVB-irradiated human keratinocytes (HaCaTs). The results indicated that ICT and ICA showed strong radical scavenging activity, and the reactive oxygen species (ROS) scavenging activity of ICT was superior. UVB-induced matrix metalloproteinase-1 (MMP-1) expression was blocked by ICA via the inhibition of mitogen-activated protein kinase/activator protein 1 (MAPK/AP-1), which directly reduced extracellular matrix (ECM) degradation. ICT activated nuclear factor erythroid 2 related factor 2 (Nrf2) to improve the anti-oxidative stress capacity and suppress nuclear factor-κB (NF-κB) activation, decreasing vascular endothelial growth factor (VEGF) protein, and inflammatory cytokines induced ECM degrading enzyme secretion. Moreover, ICT was more advantageous to improve transforming growth factor beta 1 (TGF-β1) and procollagen type I expression than ICA, promoting the synthesis of collagen. Therefore, ICA and ICT have potential to treat UVB-induced oxidative stress, inflammation and photoaging, and will be posited as a novel strategy to alleviate photodamage.
Titel: |
Icariin and icaritin recover UVB-induced photoaging by stimulating Nrf2/ARE and reducing AP-1 and NF-κB signaling pathways: a comparative study on UVB-irradiated human keratinocytes.
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Autor/in / Beteiligte Person: | Hwang, E ; Lin, P ; Ngo, HTT ; Gao, W ; Wang, YS ; Yu, HS ; Yi, TH |
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Zeitschrift: | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, Jg. 17 (2018-10-10), Heft 10, S. 1396-1408 |
Veröffentlichung: | 2021- : [London] : Springer ; <i>Original Publication</i>: Cambridge, UK : Royal Society of Chemistry, c2002-, 2018 |
Medientyp: | academicJournal |
ISSN: | 1474-9092 (electronic) |
DOI: | 10.1039/c8pp00174j |
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