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A bidirectional cross-talk is established between the nervous and immune systems through common mediators including neuropeptides, neurotransmitters, and cytokines. Among these, PACAP and VIP are two highly related neuropeptides widely distributed in the organism with purported immunomodulatory actions. Due to their well-known anti-inflammatory properties, administration of these peptides has proven to be beneficial in models of acute and chronic inflammatory diseases. Nevertheless, the relevance of the endogenous source of these peptides in the modulation of immune responses remains to be elucidated. The development of transgenic mice with specific deletions in the genes coding for these neuropeptides (Vip and Adcyap1) or for their G-protein-coupled receptors VPAC1, VPAC2, and PAC1 (Vipr1, Vipr2, Adcyap1r1) has allowed to address this question, underscoring the complexity of the immunoregulatory properties of PACAP and VIP. The goal of this review is to integrate the existing information on the immune phenotypes of mice deficient for PACAP, VIP, or their receptors, to provide a global view on the roles of these endogenous neuropeptides during immunological health and disease.

Titel:	Immunomodulatory Roles of PACAP and VIP: Lessons from Knockout Mice.
Autor/in / Beteiligte Person:	Abad, C ; Tan, YV
Link:	Zum Volltext
Zeitschrift:	Journal of molecular neuroscience : MN, Jg. 66 (2018-09-01), Heft 1, S. 102-113
Veröffentlichung:	Totowa, NJ : Humana Press ; <i>Original Publication</i>: Boston : Birkhäuser [i.e. Cambridge, MA : Birkhäuser Boston, c1989-, 2018
Medientyp:	academicJournal
ISSN:	1559-1166 (electronic)
DOI:	10.1007/s12031-018-1150-y
Schlagwort:	Animals Humans Immunologic Factors genetics Mice Mice, Knockout Pituitary Adenylate Cyclase-Activating Polypeptide immunology Pituitary Adenylate Cyclase-Activating Polypeptide metabolism Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide genetics Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide metabolism Vasoactive Intestinal Peptide immunology Vasoactive Intestinal Peptide metabolism Immunologic Factors immunology Neuroimmunomodulation Pituitary Adenylate Cyclase-Activating Polypeptide genetics Vasoactive Intestinal Peptide genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [J Mol Neurosci] 2018 Sep; Vol. 66 (1), pp. 102-113. <i>Date of Electronic Publication: </i>2018 Aug 13. MeSH Terms: Neuroimmunomodulation* ; Immunologic Factors / immunology ; Pituitary Adenylate Cyclase-Activating Polypeptide / genetics ; Vasoactive Intestinal Peptide / *genetics ; Animals ; Humans ; Immunologic Factors / genetics ; Mice ; Mice, Knockout ; Pituitary Adenylate Cyclase-Activating Polypeptide / immunology ; Pituitary Adenylate Cyclase-Activating Polypeptide / metabolism ; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide / genetics ; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide / metabolism ; Vasoactive Intestinal Peptide / immunology ; Vasoactive Intestinal Peptide / metabolism References: J Neuroimmunol. 1999 Jan 1;93(1-2):126-38. (PMID: 10378876) ; J Clin Invest. 2000 May;105(9):1307-15. 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(PMID: 9928019) Contributed Indexing: Keywords: Inflammation; Knockout; Neuroimmunology; Neuropeptides; PACAP; VIP Substance Nomenclature: 0 (Immunologic Factors) ; 0 (Pituitary Adenylate Cyclase-Activating Polypeptide) ; 0 (Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide) ; 37221-79-7 (Vasoactive Intestinal Peptide) Entry Date(s): Date Created: 20180815 Date Completed: 20181109 Latest Revision: 20200225 Update Code: 20231215

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Immunomodulatory Roles of PACAP and VIP: Lessons from Knockout Mice.