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Icariin is a traditional Chinese drug that has long been used to treat various diseases. In the present study, the effect of icariin was investigated on cutaneous wound healing. Using in vitro experiments, it was demonstrated that icariin significantly promoted the migration and proliferation of keratinocytes via the activation of AKT serine/threonine kinase 1 (AKT) and extracellular signal‑regulated kinase (ERK). Inhibition of AKT or ERK reversed the effects of icariin on the proliferation and migration of keratinocytes. In addition, icariin inhibited the production of interleukin (IL)‑6 and tumor necrosis factor (TNF)‑α and induced the production of IL‑10. Finally, animal experiments demonstrated that icariin treatment accelerated the wound closure rate. The present findings revealed that icariin may be a promising drug to promote the migration and proliferation of keratinocytes, and to accelerate the healing of skin wounds, through its role in the upregulation of AKT and ERK signaling.

Titel:	Icariin promotes wound healing by enhancing the migration and proliferation of keratinocytes via the AKT and ERK signaling pathway.
Autor/in / Beteiligte Person:	Mi, B ; Liu, J ; Liu, G ; Zhou, W ; Liu, Y ; Hu, L ; Xiong, L ; Ye, S ; Wu, Y
Zeitschrift:	International journal of molecular medicine, Jg. 42 (2018-08-01), Heft 2, S. 831
Veröffentlichung:	Athens, Greece : D.A. Spandidos, [1998-, 2018
Medientyp:	academicJournal
ISSN:	1791-244X (electronic)
DOI:	10.3892/ijmm.2018.3676
Schlagwort:	Animals Cell Line Flavonoids pharmacology Humans Keratinocytes cytology Keratinocytes metabolism MAP Kinase Signaling System drug effects Male Rats, Sprague-Dawley Signal Transduction drug effects Cell Movement drug effects Cell Proliferation drug effects Extracellular Signal-Regulated MAP Kinases metabolism Flavonoids therapeutic use Keratinocytes drug effects Proto-Oncogene Proteins c-akt metabolism Wound Healing drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Mol Med] 2018 Aug; Vol. 42 (2), pp. 831-838. <i>Date of Electronic Publication: </i>2018 May 14. MeSH Terms: Cell Movement / drug effects ; Cell Proliferation / drug effects ; Extracellular Signal-Regulated MAP Kinases / metabolism ; Flavonoids / therapeutic use ; Keratinocytes / drug effects ; Proto-Oncogene Proteins c-akt / metabolism ; Wound Healing / *drug effects ; Animals ; Cell Line ; Flavonoids / pharmacology ; Humans ; Keratinocytes / cytology ; Keratinocytes / metabolism ; MAP Kinase Signaling System / drug effects ; Male ; Rats, Sprague-Dawley ; Signal Transduction / drug effects References: Wound Repair Regen. 2017 Aug 30;:null. (PMID: 28857355) ; BMC Complement Altern Med. 2017 Aug 22;17(1):415. (PMID: 28830513) ; Cell Tissue Res. 2016 Jul;365(1):85-99. (PMID: 26888423) ; Environ Toxicol Pharmacol. 2017 Sep;54:7-13. (PMID: 28667862) ; Pharmacogn Mag. 2017 Jan-Mar;13(49):85-89. (PMID: 28216888) ; Methods. 2001 Dec;25(4):402-8. (PMID: 11846609) ; Stem Cells. 2015 Jun;33(6):1863-77. (PMID: 25787271) ; J Cell Biochem. 2018 Feb;119(2):2036-2047. (PMID: 28833404) ; Front Cell Infect Microbiol. 2016 Dec 27;6:194. (PMID: 28083516) ; Eur J Pharmacol. 2016 Sep 5;786:53-59. (PMID: 27238975) ; Int J Inflam. 2017;2017:3406215. (PMID: 28811953) ; Iran J Public Health. 2014 Jun;43(6):847-8. (PMID: 26110157) ; Am J Transl Res. 2017 May 15;9(5):2352-2362. (PMID: 28559985) ; Cell Physiol Biochem. 2016;38(3):959-68. (PMID: 26938432) ; Evid Based Complement Alternat Med. 2017;2017:2694261. (PMID: 28536643) ; An Bras Dermatol. 2016 Sep-Oct;91(5):614-620. (PMID: 27828635) ; Int Immunopharmacol. 2014 Jan;18(1):175-81. (PMID: 24295650) ; Curr Pharm Des. 2018 Feb 12;23(39):6071-6078. (PMID: 28619001) ; Phytomedicine. 2017 Feb 15;25:93-99. (PMID: 28190476) ; J Ethnopharmacol. 2012 Oct 31;144(1):182-9. (PMID: 22974545) ; Acta Cir Bras. 2013 Aug;28(8):551-8. (PMID: 23896833) ; Cell Physiol Biochem. 2017;41(4):1605-1615. (PMID: 28355606) ; Biochem Biophys Res Commun. 2003 Feb 21;301(4):841-7. (PMID: 12589789) ; Cytotechnology. 2017 Feb;69(1):19-29. (PMID: 27990569) ; J Immunol. 2008 May 1;180(9):5771-7. (PMID: 18424693) ; J Invest Dermatol. 2001 May;116(5):633-40. (PMID: 11348449) ; Plast Reconstr Surg Glob Open. 2016 Aug 11;4(8):e837. (PMID: 27622105) ; Regen Med. 2016 Mar;11(2):193-209. (PMID: 26877242) ; Cell Physiol Biochem. 2017;42(6):2582-2592. (PMID: 28848113) Substance Nomenclature: 0 (Flavonoids) ; EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) ; EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20180517 Date Completed: 20181015 Latest Revision: 20181114 Update Code: 20240513 PubMed Central ID: PMC6034939

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Icariin promotes wound healing by enhancing the migration and proliferation of keratinocytes via the AKT and ERK signaling pathway.