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Background/aims: Chronic alcohol abuse is an important risk factor for osteopenia. However, few studies have focused on the efficacy and mechanism of action of icariin on alcohol-induced osteopenia. The aim of this study was to investigate the efficacy and underlying mechanism of action of icariin in the treatment of chronic high-dose alcohol-induced osteopenia in a rat model.

Methods: Thirty-six adult male Sprague-Dawley rats were randomly divided into four groups: sham, alcohol, and low-dose and high-dose icariin groups. Bone volume fraction (BV/TV), bone mineral density (BMD), bone biomechanical properties, and bone morphology were assessed after 16 weeks. Reverse-transcription PCR was used to detect mRNA expression levels of alkaline phosphatase (ALP), collagen type I (Col I), osteocalcin (OC), runt-related transcription factor 2 (Runx2), bone morphogenetic protein-2 (BMP-2), and osteoprotegerin (OPG).

Results: Bone metabolic markers and biomechanical properties in the alcohol group were decreased significantly compared with the sham group. BV/TV, BMD, mineral apposition rate (MAR), percent trabecular area (%Tb.Ar), and bone biomechanical properties were elevated in the low-dose and high-dose icariin groups relative to the alcohol group. ALP, Col I, OC, Runx2, BMP-2, and OPG mRNA levels in the icariin group were significantly elevated in comparison with the alcohol group.

Conclusion: Icariin can prevent overall progression of chronic high-dose alcohol-induced osteopenia in a rat model, in a dose-dependent manner. Icariin promotes bone formation and inhibits bone loss, and effectively restores bone structure and strength in chronic high-dose alcohol-induced osteopenic rats. Bone metabolism reversal is evidenced by increased BV/TV, BMD, MAR, %Tb.Ar, and biomechanical properties and elevated ALP, Col I, OC, Runx2, BMP-2, and OPG mRNA levels.

Titel:	Icariin Restores Bone Structure and Strength in a Rat Model of Chronic High-Dose Alcohol-Induced Osteopenia.
Autor/in / Beteiligte Person:	Wu, JZ ; Liu, PC ; Liu, R ; Cai, M
Link:	Zum Volltext
Zeitschrift:	Cellular physiology and biochemistry : international journal of experimental cellular, Jg. 46 (2018), Heft 4, S. 1727
Veröffentlichung:	2019- : Düsseldorf, Germany : Cell Physiol Biochem Press GmbH & Co KG ; <i>Original Publication</i>: Basel ; New York : S. Karger, 1991-2018., 2018
Medientyp:	academicJournal
ISSN:	1421-9778 (electronic)
DOI:	10.1159/000489248
Schlagwort:	Alkaline Phosphatase genetics Alkaline Phosphatase metabolism Animals Bone Density drug effects Bone Diseases, Metabolic etiology Bone Diseases, Metabolic metabolism Bone Diseases, Metabolic prevention & control Bone Morphogenetic Protein 2 genetics Bone Morphogenetic Protein 2 metabolism Bone and Bones diagnostic imaging Bone and Bones metabolism Core Binding Factor Alpha 1 Subunit genetics Core Binding Factor Alpha 1 Subunit metabolism Disease Models, Animal Elastic Modulus drug effects Ethanol toxicity Femur diagnostic imaging Flavonoids therapeutic use Imaging, Three-Dimensional Male Osteocalcin genetics Osteocalcin metabolism Osteoprotegerin genetics Osteoprotegerin metabolism Rats Rats, Sprague-Dawley X-Ray Microtomography Bone and Bones drug effects Flavonoids pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Cell Physiol Biochem] 2018; Vol. 46 (4), pp. 1727-1736. <i>Date of Electronic Publication: </i>2018 Apr 23. MeSH Terms: Bone and Bones / drug effects ; Flavonoids / pharmacology ; Alkaline Phosphatase / genetics ; Alkaline Phosphatase / metabolism ; Animals ; Bone Density / drug effects ; Bone Diseases, Metabolic / etiology ; Bone Diseases, Metabolic / metabolism ; Bone Diseases, Metabolic / prevention & control ; Bone Morphogenetic Protein 2 / genetics ; Bone Morphogenetic Protein 2 / metabolism ; Bone and Bones / diagnostic imaging ; Bone and Bones / metabolism ; Core Binding Factor Alpha 1 Subunit / genetics ; Core Binding Factor Alpha 1 Subunit / metabolism ; Disease Models, Animal ; Elastic Modulus / drug effects ; Ethanol / toxicity ; Femur / diagnostic imaging ; Flavonoids / therapeutic use ; Imaging, Three-Dimensional ; Male ; Osteocalcin / genetics ; Osteocalcin / metabolism ; Osteoprotegerin / genetics ; Osteoprotegerin / metabolism ; Rats ; Rats, Sprague-Dawley ; X-Ray Microtomography Contributed Indexing: Keywords: Alcohol-induced osteopenia; Bone biomechanics; Bone histomorphometry; Icariin Substance Nomenclature: 0 (Bone Morphogenetic Protein 2) ; 0 (Core Binding Factor Alpha 1 Subunit) ; 0 (Flavonoids) ; 0 (Osteoprotegerin) ; 104982-03-8 (Osteocalcin) ; 3K9958V90M (Ethanol) ; EC 3.1.3.1 (Alkaline Phosphatase) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20180427 Date Completed: 20180705 Latest Revision: 20220410 Update Code: 20231215

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Icariin Restores Bone Structure and Strength in a Rat Model of Chronic High-Dose Alcohol-Induced Osteopenia.