Mitochondrial genetic haplogroups and incident obesity: a longitudinal cohort study.

Veronese, N ; Stubbs, B ; et al.

In: European journal of clinical nutrition, Jg. 72 (2018-04-01), Heft 4, S. 587

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Background/objectives: A small number of case-control studies have suggested that mitochondrial haplogroups could be associated with obesity. We examined whether obesity risk was influenced by mitochondrial haplogroup in a large North American cohort across an 8-year period. We conducted a longitudinal cohort study including individuals from the Osteoarthritis Initiative.

Subjects/methods: Mitochondrial haplogroups were determined by sequencing and PCR-RFLP techniques using this nomenclature: HV, JT, KU, IWX, and super HV/others. The strength of the association between mitochondrial haplogroups and incident obesity was quantified with hazard ratios (HRs), adjusted for potential confounders using a Cox's regression analysis.

Results: Overall, 2342 non-obese Caucasian participants (56.7% women) with a mean ± SD age of 62.0 ± 9.5 years at baseline were included. During a median follow-up of 8 years, 334 individuals ( = 14.3% of baseline population) became obese. After adjusting for nine potential confounders, the haplogroups IWX carried a significant 48% higher risk of obesity (HR = 1.48; 95% CI: 1.02-2.39) compared to the HV haplotype (the most frequent type).

Conclusion: Only the presence of the IWX haplogroups appears to be linked to increased obesity risk, independent of potential baseline confounders. Future cohort studies are needed to confirm these findings and to determine potential underlying mechanisms.

Titel:	Mitochondrial genetic haplogroups and incident obesity: a longitudinal cohort study.
Autor/in / Beteiligte Person:	Veronese, N ; Stubbs, B ; Koyanagi, A ; Vaona, A ; Demurtas, J ; Schofield, P ; Thompson, T ; Maggi, S
Link:	Zum Volltext
Zeitschrift:	European journal of clinical nutrition, Jg. 72 (2018-04-01), Heft 4, S. 587
Veröffentlichung:	<2003->: London : Nature Publishing Group ; <i>Original Publication</i>: London : J. Libbey, c1988-, 2018
Medientyp:	academicJournal
ISSN:	1476-5640 (electronic)
DOI:	10.1038/s41430-018-0097-y
Schlagwort:	Aged Cohort Studies Female Humans Male Middle Aged United States epidemiology DNA, Mitochondrial genetics Haplotypes genetics Obesity epidemiology Obesity genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Eur J Clin Nutr] 2018 Apr; Vol. 72 (4), pp. 587-592. <i>Date of Electronic Publication: </i>2018 Jan 31. MeSH Terms: DNA, Mitochondrial / genetics ; Haplotypes / genetics ; Obesity / epidemiology ; Obesity / genetics ; Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; United States / epidemiology Grant Information: ICA-CL-2017-03-001 United Kingdom DH_ Department of Health Substance Nomenclature: 0 (DNA, Mitochondrial) Entry Date(s): Date Created: 20180202 Date Completed: 20190305 Latest Revision: 20210109 Update Code: 20240513

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