Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation.
In: Evidence-based complementary and alternative medicine : eCAM, Jg. 2017 (2017), S. 4038371
Online
academicJournal
Zugriff:
The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D. multiflora) on Shigella flexneri -induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 10 9 cells/mL S. flexneri to rats. Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg. The level of biochemical parameters was assessed and organs histology examined by 14 days' subacute toxicity. S. flexneri stool load decreased significantly in dose-dependent manner. The level of ALT increased ( p < 0.05) in male rats treated with the dose of 445.68 mg/kg while creatinine level increased in rats treated with both doses. In female rats, a significant decrease ( p < 0.05) of the level of AST and creatinine was noted in rats treated with the dose of 222.84 mg/kg of D. multiflora . Histological exams of kidney and liver of treated rats showed architectural modifications at the dose of 445.68 mg/kg. This finding suggests that D. multiflora leaf extract is efficient against diarrhea caused by S. flexneri but the treatment with doses lower than 222.84 mg/kg is recommended while further study is required to define the exact efficient nontoxic dose.
Titel: |
Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation.
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Autor/in / Beteiligte Person: | Afagnigni, AD ; Nyegue, MA ; Ndoye Foe, CF ; Njankouo Ndam, Y ; Njayou, FN ; Fonkoua, MC ; Etoa, FX |
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Zeitschrift: | Evidence-based complementary and alternative medicine : eCAM, Jg. 2017 (2017), S. 4038371 |
Veröffentlichung: | 2011- : New York, NY : Hindawi Pub. ; <i>Original Publication</i>: Oxford, UK : Oxford University Press, c2004-, 2017 |
Medientyp: | academicJournal |
ISSN: | 1741-427X (print) |
DOI: | 10.1155/2017/4038371 |
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