Einzeltreffer — DigiBib

Mitochondrial antiviral-signaling protein (MAVS) transmits signals from RIG-I-like receptors after RNA virus infections. However, the mechanism by which MAVS activates downstream components, such as TBK1 and IKKα/β, is unclear, although previous work suggests the involvement of NEMO or TBK1-binding proteins TANK, NAP1, and SINTBAD. Here, we report that MAVS-mediated innate immune activation is dependent on TRAFs, partially on NEMO, but not on TBK1-binding proteins. MAVS recruited TBK1/IKKε by TRAFs that were pre-associated with TBK1/IKKε via direct interaction between the coiled-coil domain of TRAFs and the SDD domain of TBK1/IKKε. TRAF2-/-3-/-5-/-6-/- cells completely lost RNA virus responses. TRAFs' E3 ligase activity was required for NEMO activation by synthesizing ubiquitin chains that bound to NEMO for NF-κB and TBK1/IKKε activation. NEMO-activated IKKα/β were important for TBK1/IKKε activation through IKKα/β-mediated TBK1/IKKε phosphorylation. Moreover, individual TRAFs differently mediated TBK1/IKKε activation and thus fine-tuned antiviral immunity under physiological conditions.

Titel:	MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner.
Autor/in / Beteiligte Person:	Fang, R ; Jiang, Q ; Zhou, X ; Wang, C ; Guan, Y ; Tao, J ; Xi, J ; Feng, JM ; Jiang, Z
Link:	Zum Volltext
Zeitschrift:	PLoS pathogens, Jg. 13 (2017-11-10), Heft 11, S. e1006720
Veröffentlichung:	San Francisco, CA : Public Library of Science, c2005-, 2017
Medientyp:	academicJournal
ISSN:	1553-7374 (electronic)
DOI:	10.1371/journal.ppat.1006720
Schlagwort:	Adaptor Proteins, Signal Transducing genetics HEK293 Cells Humans Immunity, Innate immunology Phosphorylation Protein Serine-Threonine Kinases genetics Sendai virus Ubiquitination Adaptor Proteins, Signal Transducing metabolism I-kappa B Kinase metabolism Protein Serine-Threonine Kinases metabolism Signal Transduction genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [PLoS Pathog] 2017 Nov 10; Vol. 13 (11), pp. e1006720. <i>Date of Electronic Publication: </i>2017 Nov 10 (<i>Print Publication: </i>2017). MeSH Terms: Adaptor Proteins, Signal Transducing / metabolism ; I-kappa B Kinase / metabolism ; Protein Serine-Threonine Kinases / metabolism ; Signal Transduction / genetics ; Adaptor Proteins, Signal Transducing / genetics ; HEK293 Cells ; Humans ; Immunity, Innate / immunology ; Phosphorylation ; Protein Serine-Threonine Kinases / genetics ; Sendai virus ; Ubiquitination References: Nat Immunol. 2009 Sep;10(9):965-72. (PMID: 19668221) ; Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6322-7. (PMID: 11972054) ; Sci Signal. 2012 Nov 13;5(250):ra81. (PMID: 23150880) ; Mol Cell. 2005 Sep 16;19(6):727-40. (PMID: 16153868) ; Cell Res. 2013 Apr;23(4):465-72. (PMID: 23528705) ; Nat Immunol. 2011 Feb;12 (2):137-43. (PMID: 21217758) ; Nat Immunol. 2007 Jun;8(6):592-600. (PMID: 17468758) ; PLoS One. 2011;6(9):e23971. (PMID: 21931631) ; EMBO J. 2000 Sep 15;19(18):4976-85. (PMID: 10990461) ; Mol Cell. 2009 Oct 23;36(2):315-25. (PMID: 19854139) ; Mod Pathol. 2000 Dec;13(12):1324-31. (PMID: 11144929) ; Elife. 2013 Aug 14;2:e00785. (PMID: 23951545) ; EMBO J. 2007 Jul 11;26(13):3180-90. (PMID: 17568778) ; Biochem J. 2011 Feb 15;434(1):93-104. (PMID: 21138416) ; Cell Rep. 2013 Mar 28;3(3):734-46. (PMID: 23453971) ; Cell. 2010 Apr 16;141(2):315-30. (PMID: 20403326) ; Elife. 2014 Jan 01;3:e01489. (PMID: 24569476) ; Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7. (PMID: 20080593) ; J Immunol. 2005 Oct 15;175(8):5260-8. (PMID: 16210631) ; Cell Res. 2015 May;25(5):539-50. (PMID: 25837739) ; J Immunol. 2006 Dec 15;177(12):8676-83. (PMID: 17142768) ; Cell Host Microbe. 2010 Dec 16;8(6):496-509. (PMID: 21147464) ; Cell. 2010 Mar 19;140(6):805-20. (PMID: 20303872) ; Proc Natl Acad Sci U S A. 2009 May 26;106(21):8653-8. (PMID: 19433799) ; EMBO J. 1999 Dec 1;18(23):6694-704. (PMID: 10581243) ; PLoS One. 2010 Feb 11;5(2):e9172. (PMID: 20161788) ; Cell. 2011 Oct 14;147(2):436-46. (PMID: 22000020) ; Nat Immunol. 2005 Oct;6(10 ):981-8. (PMID: 16127453) ; Cell. 2011 Aug 5;146(3):448-61. (PMID: 21782231) ; Nature. 2006 May 4;441(7089):101-5. (PMID: 16625202) ; J Biol Chem. 1996 Nov 15;271(46):28745-8. (PMID: 8910514) ; Science. 2015 Mar 13;347(6227):aaa2630. (PMID: 25636800) ; J Immunol. 2007 May 15;178(10 ):6444-55. (PMID: 17475874) ; Nat Immunol. 2004 Jul;5(7):730-7. (PMID: 15208624) ; Cell. 2011 Oct 14;147(2):409-22. (PMID: 22000018) ; Mol Cell Biol. 2002 Oct;22(20):7158-67. (PMID: 12242293) ; Immunity. 2012 Jun 29;36(6):959-73. (PMID: 22705106) ; Curr Eye Res. 2013 Feb;38(2):310-5. (PMID: 23286385) ; J Biol Chem. 2004 Apr 9;279(15):15652-61. (PMID: 14739303) ; Nature. 2007 Apr 19;446(7138):916-920. (PMID: 17392790) ; EMBO J. 2006 Jul 26;25(14):3257-63. (PMID: 16858409) ; Proc Natl Acad Sci U S A. 2006 May 30;103(22):8459-64. (PMID: 16714379) ; J Mol Signal. 2013 Jun 13;8(1):7. (PMID: 23758787) ; Cell Rep. 2013 Mar 28;3(3):747-58. (PMID: 23453972) ; Nature. 1997 Aug 7;388(6642):548-54. (PMID: 9252186) ; Nat Immunol. 2009 Dec;10 (12 ):1300-8. (PMID: 19881509) ; J Immunol. 2000 Nov 1;165(9):5084-96. (PMID: 11046039) ; Cell. 2011 Oct 14;147(2):423-35. (PMID: 22000019) ; Fish Shellfish Immunol. 2015 Apr;43(2):460-8. (PMID: 25655327) ; J Biol Chem. 1998 Feb 13;273(7):4129-34. (PMID: 9461607) ; Mol Cell. 2000 Jun;5(6):969-79. (PMID: 10911991) ; J Biol Chem. 2015 Oct 30;290(44):26811-20. (PMID: 26385923) ; Cell. 2005 Sep 9;122(5):669-82. (PMID: 16125763) ; J Biol Chem. 2009 Jan 9;284(2):807-17. (PMID: 19017631) ; Mol Cell. 2014 Aug 21;55(4):511-23. (PMID: 25018021) ; Elife. 2015 Aug 28;4:null. (PMID: 26314863) ; Nature. 2011 Sep 25;479(7373):423-7. (PMID: 21947008) ; Nature. 2005 Oct 20;437(7062):1167-72. (PMID: 16177806) ; J Biol Chem. 2002 Oct 4;277(40):37029-36. (PMID: 12133833) ; Mol Cell. 2006 Apr 21;22(2):245-57. (PMID: 16603398) Substance Nomenclature: 0 (Adaptor Proteins, Signal Transducing) ; 0 (IKBKG protein, human) ; 0 (MAVS protein, human) ; EC 2.7.11.1 (Protein Serine-Threonine Kinases) ; EC 2.7.11.10 (I-kappa B Kinase) Entry Date(s): Date Created: 20171111 Date Completed: 20171205 Latest Revision: 20211204 Update Code: 20231215 PubMed Central ID: PMC5699845

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner.