Reduced protein expressions of cytomembrane GABA <subscript>A</subscript> Rβ3 at different postnatal developmental stages of rats exposed prenatally to valproic acid.

Li, Y ; Zhou, Y ; et al.

In: Brain research, Jg. 1671 (2017-09-15), S. 33

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Decreased inhibition plays an extremely important role in pathogenesis of autism spectrum disorder (ASD). Therefore, we aimed to determine whether expression levels of the γ-aminobutyric acid type A receptor β3 subunit (GABA A Rβ3), K + -Cl - cotransporter 2 (KCC2), and Na + -K + -Cl - cotransporter 1 (NKCC1) related to inhibition transmission are changed in a sodium valproate-induced rat model of ASD. Decreased expression levels of membrane GABA A Rβ3 (m-GABA A Rβ3) and KCC2 as well as increased endocytosis of GABA A Rs were found in the model group. However, there were no significant differences in expression of total GABA A Rβ3 and NKCC1 between the control and model groups. In addition, we observed growth retardation, impaired spatial memory, limited exploration, increased anxiety, and reduced sociability in the model group. These results suggest alterations in m-GABA A Rβ3 levels, KCC2 levels, and trafficking of GABA A Rs in rats prenatally exposed to valproic acid and advance our understanding of the pathogenesis of ASD.

Titel:	Reduced protein expressions of cytomembrane GABA <subscript>A</subscript> Rβ3 at different postnatal developmental stages of rats exposed prenatally to valproic acid.
Autor/in / Beteiligte Person:	Li, Y ; Zhou, Y ; Peng, L ; Zhao, Y
Link:	Zum Volltext
Zeitschrift:	Brain research, Jg. 1671 (2017-09-15), S. 33
Veröffentlichung:	Amsterdam Elsevier/North-Holland Biomedical Press., 2017
Medientyp:	academicJournal
ISSN:	1872-6240 (electronic)
DOI:	10.1016/j.brainres.2017.06.018
Schlagwort:	Animals Brain growth & development Brain metabolism Disease Models, Animal Dose-Response Relationship, Drug Female Male Neurons metabolism Pregnancy Rats Rats, Sprague-Dawley Receptors, GABA-A metabolism Solute Carrier Family 12, Member 2 metabolism Symporters metabolism Valproic Acid administration & dosage gamma-Aminobutyric Acid metabolism K Cl- Cotransporters Autism Spectrum Disorder metabolism Prenatal Exposure Delayed Effects chemically induced Receptors, GABA-A biosynthesis Valproic Acid toxicity
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Brain Res] 2017 Sep 15; Vol. 1671, pp. 33-42. <i>Date of Electronic Publication: </i>2017 Jun 19. MeSH Terms: Autism Spectrum Disorder / metabolism ; Prenatal Exposure Delayed Effects / chemically induced ; Receptors, GABA-A / biosynthesis ; Valproic Acid / toxicity ; Animals ; Brain / growth & development ; Brain / metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Male ; Neurons / metabolism ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA-A / metabolism ; Solute Carrier Family 12, Member 2 / metabolism ; Symporters / metabolism ; Valproic Acid / administration & dosage ; gamma-Aminobutyric Acid / metabolism ; K Cl- Cotransporters Contributed Indexing: Keywords: GABA(A)Rs endocytosis; GABA(A)Rβ3; VPA-induced rat model Substance Nomenclature: 0 (Receptors, GABA-A) ; 0 (Solute Carrier Family 12, Member 2) ; 0 (Symporters) ; 56-12-2 (gamma-Aminobutyric Acid) ; 614OI1Z5WI (Valproic Acid) Entry Date(s): Date Created: 20170624 Date Completed: 20180517 Latest Revision: 20231213 Update Code: 20240513

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