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BACKGROUND The aim of this study was to explore the effect and possible mechanism of sodium valproate (VPA) on the cognitive function and the hippocampus of rats after convulsive status epilepticus (CES). MATERIAL AND METHODS A rat model of CES was established and the Morris water maze was used to observe changes in the cognitive function of the rats after the administration of VPA. Acute hippocampal slices were made to detect field excitatory postsynaptic potential. Western blot analysis was used to test for the expression of CaMKII and p-CaMKII. RESULTS (1) CSE caused no spatial reference memory (SFM) or spatial working memory (SWM) damage to 15-day-old (P15) rats, but caused significant SRM and SWM damage to 35-day-old (P35) rats. VPA damaged the SRM and SWM of P15 rats in both the CSE and control groups. However, VPA improved the memory damage caused by CSE in P35 rats. (2) VPA treatment in vivo increased the induced success rate and the sustainable time of long-term potentiation (LTP) in P35 rats, and also inhibited the expression of CaMKII and p-CaMKII in both P15 and P35 rats. CONCLUSIONS VPA significantly improved spatial cognitive dysfunction in a CSE model of P35 rats, and damaged the spatial memory of normal P15 and P35 rats. Improvements after administration of VPA were closely related to the increase of induced success rate and the prolongation of the sustainable time of LTP. VPA treatment in vivo, which inhibited expression and phosphorylation of CaMKII, showed no obvious inhibition on LTP, which may be related to the elution effect of VPA.

Titel:	Effect of Sodium Valproate on Cognitive Function and Hippocampus of Rats After Convulsive Status Epilepticus.
Autor/in / Beteiligte Person:	Wu, P ; Hong, S ; Zhong, M ; Guo, Y ; Chen, H ; Jiang, L
Link:	Zum Volltext
Zeitschrift:	Medical science monitor : international medical journal of experimental and clinical research, Jg. 22 (2016-12-29), S. 5197
Veröffentlichung:	2014- : Smithtown, NY : International Scientific Information, Inc. ; <i>Original Publication</i>: Warsaw, Poland : Medical Science International, 2016
Medientyp:	academicJournal
ISSN:	1643-3750 (electronic)
DOI:	10.12659/msm.898859
Schlagwort:	Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 metabolism Excitatory Postsynaptic Potentials drug effects Hippocampus drug effects Learning drug effects Long-Term Potentiation drug effects Memory, Short-Term drug effects Phosphorylation drug effects Rats, Wistar Spatial Memory drug effects Cognition drug effects Hippocampus physiopathology Seizures drug therapy Seizures physiopathology Valproic Acid pharmacology Valproic Acid therapeutic use
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Med Sci Monit] 2016 Dec 29; Vol. 22, pp. 5197-5205. <i>Date of Electronic Publication: </i>2016 Dec 29. MeSH Terms: Cognition / drug effects ; Hippocampus / physiopathology ; Seizures / drug therapy ; Seizures / physiopathology ; Valproic Acid / pharmacology ; Valproic Acid / therapeutic use ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism ; Excitatory Postsynaptic Potentials / drug effects ; Hippocampus / drug effects ; Learning / drug effects ; Long-Term Potentiation / drug effects ; Memory, Short-Term / drug effects ; Phosphorylation / drug effects ; Rats, Wistar ; Spatial Memory / drug effects References: Exp Brain Res. 2015 Sep;233(9):2733-43. (PMID: 26169100) ; Science. 1999 Sep 17;285(5435):1870-4. (PMID: 10489359) ; Exp Neurol. 1986 Dec;94(3):659-69. (PMID: 3780912) ; Dev Med Child Neurol. 2004 Jan;46(1):4-8. (PMID: 14974641) ; Brain Res Brain Res Rev. 2001 Aug;36(1):60-90. (PMID: 11516773) ; Neuroscientist. 2007 Jun;13(3):280-91. (PMID: 17519370) ; Neurology. 2010 Feb 23;74(8):636-42. (PMID: 20089940) ; Annu Rev Psychol. 2010;61:49-79, C1-4. (PMID: 19575620) ; J Neurol Sci. 2003 Jul 15;211(1-2):37-41. (PMID: 12767495) ; Behav Brain Res. 1997 Apr;85(1):47-55. (PMID: 9095341) ; Epilepsia. 2007 Jul;48(7):1245-58. (PMID: 17441999) ; J Neurosci. 2004 Mar 31;24(13):3242-50. (PMID: 15056703) ; Neuropsychiatr Dis Treat. 2009;5:527-33. (PMID: 19898666) ; Crit Care Clin. 2014 Oct;30(4):751-64. (PMID: 25257739) ; Nat Rev Neurosci. 2002 Mar;3(3):175-90. (PMID: 11994750) ; PLoS One. 2014 Oct 22;9(10):e110193. (PMID: 25337814) ; Epilepsia. 2009 Dec;50 Suppl 12:32-3. (PMID: 19941519) ; Epilepsy Behav. 2015 Aug;49:76-82. (PMID: 26210064) ; Nat Rev Neurosci. 2003 Oct;4(10):829-39. (PMID: 14523382) ; Epilepsy Res. 2003 Mar;53(3):216-24. (PMID: 12694930) ; Pharmacol Rep. 2013;65(4):787-801. (PMID: 24145073) Substance Nomenclature: 614OI1Z5WI (Valproic Acid) ; EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2) Entry Date(s): Date Created: 20161230 Date Completed: 20170424 Latest Revision: 20240324 Update Code: 20240324 PubMed Central ID: PMC5218388

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Effect of Sodium Valproate on Cognitive Function and Hippocampus of Rats After Convulsive Status Epilepticus.