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Context: Duck virus hepatitis (DVH) caused by duck hepatitis A virus type 1 (DHAV-1) is an acute and lethal disease of young ducklings. However, there is still no effective drug to treat DVH.

Objective: This study assessed the curative effect on DVH of a flavonoid prescription baicalin-linarin-icariin-notoginsenoside R1 (BLIN) as well as the hepatoprotective and antioxidative effects of BLIN.

Materials and Methods: MTT method was used to test the anti-DHAV-1 ability of BLIN in vitro. We then treated ducklings by BLIN (3 mg per duckling, once a day for 5 days) to evaluate the in vivo efficacy. To study the hepatoprotective and antioxidative roles of BLIN in its curative effect on DVH, we investigated the hepatic injury evaluation biomarkers and the oxidative stress evaluation indices of the ducklings.

Results: On duck embryonic hepatocytes, DHAV-1 inhibitory rate of BLIN at 20 μg/mL was 69.3%. The survival rate of ducklings treated by BLIN was about 35.5%, which was significantly higher than that of virus control (0.0%). After the treatment of BLIN, both the hepatic injury and the oxidative stress of infected ducklings alleviated. At the same time, a significant positive correlation (p < 0.05) existed between the hepatic injury indices and the oxidative stress indices.

Conclusions: BLIN showed a significant curative effect on DVH. The antioxidative and hepatoprotective effects of BLIN made great contributions to the treatment of DVH. Furthermore, BLIN is expected to be exploited as a new drug for the clinical treatment of DVH.

Titel:	Treatment effect of a flavonoid prescription on duck virus hepatitis by its hepatoprotective and antioxidative ability.
Autor/in / Beteiligte Person:	Chen, Y ; Zeng, L ; Lu, Y ; Yang, Y ; Xu, M ; Wang, Y ; Liu, J
Link:	Zum Volltext
Zeitschrift:	Pharmaceutical biology, Jg. 55 (2017-12-01), Heft 1, S. 198
Veröffentlichung:	[London] : Taylor & Francis ; <i>Original Publication</i>: Lisse, the Netherlands : Swets & Zeitlinger, c1998-, 2017
Medientyp:	academicJournal
ISSN:	1744-5116 (electronic)
DOI:	10.1080/13880209.2016.1255977
Schlagwort:	Animals Animals, Newborn Biomarkers metabolism Cells, Cultured Drug Combinations Ginsenosides pharmacology Glycosides pharmacology Hepatitis Virus, Duck pathogenicity Hepatitis, Animal metabolism Hepatitis, Animal pathology Hepatitis, Animal virology Hepatocytes metabolism Hepatocytes pathology Hepatocytes virology Liver metabolism Liver pathology Liver virology Poultry Diseases metabolism Poultry Diseases pathology Poultry Diseases virology Time Factors Antioxidants pharmacology Antiviral Agents pharmacology Ducks Flavonoids pharmacology Hepatitis Virus, Duck drug effects Hepatitis, Animal drug therapy Hepatocytes drug effects Liver drug effects Oxidative Stress drug effects Poultry Diseases drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Pharm Biol] 2017 Dec; Vol. 55 (1), pp. 198-205. MeSH Terms: Ducks* ; Antioxidants / pharmacology ; Antiviral Agents / pharmacology ; Flavonoids / pharmacology ; Hepatitis Virus, Duck / drug effects ; Hepatitis, Animal / drug therapy ; Hepatocytes / drug effects ; Liver / drug effects ; Oxidative Stress / drug effects ; Poultry Diseases / *drug therapy ; Animals ; Animals, Newborn ; Biomarkers / metabolism ; Cells, Cultured ; Drug Combinations ; Ginsenosides / pharmacology ; Glycosides / pharmacology ; Hepatitis Virus, Duck / pathogenicity ; Hepatitis, Animal / metabolism ; Hepatitis, Animal / pathology ; Hepatitis, Animal / virology ; Hepatocytes / metabolism ; Hepatocytes / pathology ; Hepatocytes / virology ; Liver / metabolism ; Liver / pathology ; Liver / virology ; Poultry Diseases / metabolism ; Poultry Diseases / pathology ; Poultry Diseases / virology ; Time Factors References: Virus Res. 2008 Oct;137(1):137-41. (PMID: 18585813) ; J Hepatol. 2013 Feb;58(2):329-34. (PMID: 23085647) ; Carbohydr Polym. 2014 Feb 15;102:333-40. (PMID: 24507289) ; Int J Biol Macromol. 2011 Apr 1;48(3):439-44. (PMID: 21238483) ; Biochim Biophys Acta. 2006 Dec;1763(12):1755-66. (PMID: 17034877) ; J Hepatol. 2011 Apr;54(4):773-94. (PMID: 21145849) ; Dig Liver Dis. 2014 Oct;46(10):909-15. (PMID: 24953204) ; Virus Res. 2013 Dec 26;178(2):211-6. (PMID: 24144860) ; Free Radic Biol Med. 2013 Sep;64:69-77. (PMID: 23797034) ; Carbohydr Polym. 2013 Jul 25;96(2):516-21. (PMID: 23768595) ; Pharmacol Res. 2011 Nov;64(5):517-27. (PMID: 21864684) ; J Hepatol. 2013 Feb;58(2):365-74. (PMID: 23023012) ; Virology. 2007 Apr 25;361(1):9-17. (PMID: 17300822) ; Free Radic Biol Med. 2012 Apr 1;52(7):1135-50. (PMID: 22306508) ; J Microbiol Methods. 2009 Jun;77(3):332-6. (PMID: 19475729) ; Int J Pharm. 2011 Jun 15;411(1-2):98-105. (PMID: 21453764) ; J Ethnopharmacol. 2012 Oct 11;143(3):851-8. (PMID: 22925947) ; BMC Vet Res. 2014 Sep 24;10:226. (PMID: 25244948) ; Arch Pharm Res. 2014 Mar;37(3):371-8. (PMID: 23771520) ; Comp Biochem Physiol C Toxicol Pharmacol. 2005 Jul;141(3):314-23. (PMID: 16107325) ; Metabolism. 2014 Jun;63(6):773-82. (PMID: 24726813) ; Int J Biol Macromol. 2014 May;66:186-93. (PMID: 24582875) ; Endocrinology. 2008 May;149(5):2433-42. (PMID: 18187555) ; Food Chem Toxicol. 2013 Jan;51:15-25. (PMID: 23017782) ; Poult Sci. 2006 Dec;85(12):2169-75. (PMID: 17135673) ; Sci Rep. 2014 Jun 26;4:5452. (PMID: 24965553) ; J Virol Methods. 2014 Nov;208:166-70. (PMID: 25110119) ; Eur J Med Chem. 2014 Sep 12;84:206-39. (PMID: 25019478) ; Int J Biol Macromol. 2012 Oct;51(3):201-8. (PMID: 22575392) ; Toxicol Appl Pharmacol. 2005 May 1;204(3):263-73. (PMID: 15845418) ; Int J Biochem Cell Biol. 2007;39(1):44-84. (PMID: 16978905) ; Vet Microbiol. 2008 Oct 15;131(3-4):247-57. (PMID: 18462894) Contributed Indexing: Keywords: Duck hepatitis A virus type 1; antioxidative effect; baicalin-linarin-icariin-notoginsenoside R1; hepatoprotective ability Substance Nomenclature: 0 (Antioxidants) ; 0 (Antiviral Agents) ; 0 (Biomarkers) ; 0 (Drug Combinations) ; 0 (Flavonoids) ; 0 (Ginsenosides) ; 0 (Glycosides) ; 347Q89U4M5 (baicalin) ; HBH2I685IU (linarin) ; VNM47R2QSQ (icariin) ; Z62692362Z (notoginsenoside R1) Entry Date(s): Date Created: 20161209 Date Completed: 20170310 Latest Revision: 20220311 Update Code: 20240513 PubMed Central ID: PMC6130485

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Treatment effect of a flavonoid prescription on duck virus hepatitis by its hepatoprotective and antioxidative ability.