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To investigate whether the systematic administration of icariin (ICA) promotes tendon-bone healing after rotator cuff reconstruction in vivo, a total of 64 male Sprague Dawley rats were used in a rotator cuff injury model and underwent rotator cuff reconstruction (bone tunnel suture fixation). Rats from the ICA group ( n = 32) were gavage-fed daily with ICA at 0.125 mg/g, while rats in the control group ( n = 32) received saline only. Micro-computed tomography, biomechanical tests, serum ELISA (calcium; Ca, alkaline phosphatase; AP, osteocalcin; OCN) and histological examinations (Safranin O and Fast Green staining, type I, II and III collagen (Col1, Col2, and Col3), CD31, and vascular endothelial growth factor (VEGF)) were analyzed two and four weeks after surgery. In the ICA group, the serum levels of AP and OCN were higher than in the control group. More Col1-, Col2-, CD31-, and VEGF-positive cells, together with a greater degree of osteogenesis, were detected in the ICA group compared with the control group. During mechanical testing, the ICA group showed a significantly higher ultimate failure load than the control group at both two and four weeks. Our results indicate that the systematic administration of ICA could promote angiogenesis and tendon-bone healing after rotator cuff reconstruction, with superior mechanical strength compared with the controls. Treatment for rotator cuff injury using systematically-administered ICA could be a promising strategy.

Competing Interests: The authors declare that they have no competing interests.

Titel:	Icariin Promotes Tendon-Bone Healing during Repair of Rotator Cuff Tears: A Biomechanical and Histological Study.
Autor/in / Beteiligte Person:	Ye, C ; Zhang, W ; Wang, S ; Jiang, S ; Yu, Y ; Chen, E ; Xue, D ; Chen, J ; He, R
Link:	Zum Volltext
Zeitschrift:	International journal of molecular sciences, Jg. 17 (2016-10-25), Heft 11
Veröffentlichung:	Basel, Switzerland : MDPI, [2000-, 2016
Medientyp:	academicJournal
ISSN:	1422-0067 (electronic)
DOI:	10.3390/ijms17111780
Schlagwort:	Animals Collagen biosynthesis Disease Models, Animal Humans Male Rats Rotator Cuff drug effects Rotator Cuff pathology Rotator Cuff Injuries pathology Tendons drug effects Tendons pathology Vascular Endothelial Growth Factor A Wound Healing drug effects X-Ray Microtomography Flavonoids administration & dosage Osteogenesis drug effects Rotator Cuff Injuries drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Mol Sci] 2016 Oct 25; Vol. 17 (11). <i>Date of Electronic Publication: </i>2016 Oct 25. MeSH Terms: Flavonoids / administration & dosage ; Osteogenesis / drug effects ; Rotator Cuff Injuries / *drug therapy ; Animals ; Collagen / biosynthesis ; Disease Models, Animal ; Humans ; Male ; Rats ; Rotator Cuff / drug effects ; Rotator Cuff / pathology ; Rotator Cuff Injuries / pathology ; Tendons / drug effects ; Tendons / pathology ; Vascular Endothelial Growth Factor A ; Wound Healing / drug effects ; X-Ray Microtomography References: J Bone Joint Surg Am. 2007 Jul;89(7):1533-41. (PMID: 17606793) ; Int J Mol Sci. 2012;13(1):866-78. (PMID: 22312291) ; J Bone Joint Surg Br. 2008 Oct;90(10 ):1341-7. (PMID: 18827245) ; Br J Pharmacol. 2010 Feb;159(4):939-49. (PMID: 20128811) ; Brain Res. 2006 Feb 16;1073-1074:190-201. 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Icariin Promotes Tendon-Bone Healing during Repair of Rotator Cuff Tears: A Biomechanical and Histological Study.