Epimedium koreanum Nakai and its main constituent icariin suppress lipid accumulation during adipocyte differentiation of 3T3-L1 preadipocytes.

Han, YY ; Song, MY ; et al.

In: Chinese journal of natural medicines, Jg. 14 (2016-09-01), Heft 9, S. 671

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Obesity is associated with a number of metabolic abnormalities such as type 2 diabetes and has become a major health problem worldwide. In the present study, we investigated the effects of Epimedium koreanum Nakai (Herba Epimedii, HE) and its main constituent icariin on the adipocyte differentiation in 3T3-L1 preadipocytes. HE extract and icariin significantly reduced lipid accumulation and suppressed the expressions of PPARγ, C/EBPα, and SREBP-1c in 3T3-L1 adipocytes. They also inhibited fatty acid synthase (FAS), acyl-Co A synthase (ACS1), and perilipin. Moreover, HE extract and icariin markedly increased the phosphorylation of AMPK. These results indicated that HE extract and icariin can inhibit the adipocyte differentiation through downregulation of the adipogenic transcription factors, suggesting that HE containing icariin may be used as a potential therapeutic agent in the treatment and prevention of obesity.

Titel:	Epimedium koreanum Nakai and its main constituent icariin suppress lipid accumulation during adipocyte differentiation of 3T3-L1 preadipocytes.
Autor/in / Beteiligte Person:	Han, YY ; Song, MY ; Hwang, MS ; Hwang, JH ; Park, YK ; Jung, HW
Link:	Zum Volltext
Zeitschrift:	Chinese journal of natural medicines, Jg. 14 (2016-09-01), Heft 9, S. 671
Veröffentlichung:	<2009-> : Beijing : Science Press ; Elsevier ; <i>Original Publication</i>: Nanjing : Ke xue chu ban she, 2016
Medientyp:	academicJournal
ISSN:	1875-5364 (electronic)
DOI:	10.1016/S1875-5364(16)30079-6
Schlagwort:	3T3-L1 Cells Adipocytes cytology Adipocytes metabolism Animals CCAAT-Enhancer-Binding Protein-alpha genetics CCAAT-Enhancer-Binding Protein-alpha metabolism Mice PPAR gamma genetics PPAR gamma metabolism Sterol Regulatory Element Binding Protein 1 genetics Sterol Regulatory Element Binding Protein 1 metabolism Adipocytes drug effects Adipogenesis drug effects Epimedium chemistry Flavonoids pharmacology Lipid Metabolism drug effects Plant Extracts pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Chin J Nat Med] 2016 Sep; Vol. 14 (9), pp. 671-676. MeSH Terms: Adipocytes / drug effects ; Adipogenesis / drug effects ; Epimedium / chemistry ; Flavonoids / pharmacology ; Lipid Metabolism / drug effects ; Plant Extracts / pharmacology ; 3T3-L1 Cells ; Adipocytes / cytology ; Adipocytes / metabolism ; Animals ; CCAAT-Enhancer-Binding Protein-alpha / genetics ; CCAAT-Enhancer-Binding Protein-alpha / metabolism ; Mice ; PPAR gamma / genetics ; PPAR gamma / metabolism ; Sterol Regulatory Element Binding Protein 1 / genetics ; Sterol Regulatory Element Binding Protein 1 / metabolism Contributed Indexing: Keywords: 3T3-L1 cells; Epimedium koreanum Nakai; Herba Epimedii; Icariin; Obesity Substance Nomenclature: 0 (CCAAT-Enhancer-Binding Protein-alpha) ; 0 (Flavonoids) ; 0 (PPAR gamma) ; 0 (Plant Extracts) ; 0 (Sterol Regulatory Element Binding Protein 1) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20160927 Date Completed: 20170227 Latest Revision: 20170923 Update Code: 20240513

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