Einzeltreffer — DigiBib

Excitotoxicity is one of the most extensively studied causes of neuronal death and plays an important role in Alzheimer's disease (AD). Icariin is a flavonoid component of a traditional Chinese medicine reported to possess a broad spectrum of pharmacological effects. The present study was designed to investigate the effects of icariin against learning and memory impairment induced by excitotoxicity. Here, we demonstrated that rats receiving intracerebroventricular injection of excitatory neurotoxin ibotenic acid exhibited impaired learning and memory. Oral administration of icariin at doses of 20 and 40mg/kg rescued behavioral performance and protected against neurotoxicity in rat hippocampus by suppressing ibotenic acid induced pro-apoptosis. Furthermore, Western blott of hippocampal specimens revealed that icariin up-regulated the expression of calbindin-D28k protein following ibotenic acid administration. Additionally, icariin inhibited mitogen-activated protein kinase (MAPK) family phosphorylation and nuclear factor kappa B (NF-κB) signaling, implicating the MAPK signaling and NF-κB signaling pathways were involved in the mechanism underlying icariin-mediated neuroprotection against ibotenic acid-induced excitotoxicity. These data suggested that icariin could be a potential agent for treatment of excitotoxicity-related diseases, including AD.

Titel:	Icariin, a major constituent from Epimedium brevicornum, attenuates ibotenic acid-induced excitotoxicity in rat hippocampus.
Autor/in / Beteiligte Person:	Zong, N ; Li, F ; Deng, Y ; Shi, J ; Jin, F ; Gong, Q
Link:	Zum Volltext
Zeitschrift:	Behavioural brain research, Jg. 313 (2016-10-15), S. 111
Veröffentlichung:	Amsterdam, Elsevier/North-Holland Biomedical Press., 2016
Medientyp:	academicJournal
ISSN:	1872-7549 (electronic)
DOI:	10.1016/j.bbr.2016.06.055
Schlagwort:	Administration, Oral Alzheimer Disease prevention & control Animals Calbindins metabolism Drugs, Chinese Herbal administration & dosage Epimedium Excitatory Amino Acid Agonists administration & dosage Hippocampus metabolism Ibotenic Acid administration & dosage Infusions, Intraventricular MAP Kinase Signaling System drug effects Male NF-kappa B metabolism Neurons drug effects Neurons pathology Rats Rats, Sprague-Dawley Spatial Learning drug effects Spatial Memory drug effects Apoptosis drug effects Flavonoids administration & dosage Hippocampus drug effects Hippocampus pathology Neuroprotective Agents administration & dosage
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Behav Brain Res] 2016 Oct 15; Vol. 313, pp. 111-119. <i>Date of Electronic Publication: </i>2016 Jun 28. MeSH Terms: Apoptosis / drug effects ; Flavonoids / administration & dosage ; Hippocampus / drug effects ; Hippocampus / pathology ; Neuroprotective Agents / *administration & dosage ; Administration, Oral ; Alzheimer Disease / prevention & control ; Animals ; Calbindins / metabolism ; Drugs, Chinese Herbal / administration & dosage ; Epimedium ; Excitatory Amino Acid Agonists / administration & dosage ; Hippocampus / metabolism ; Ibotenic Acid / administration & dosage ; Infusions, Intraventricular ; MAP Kinase Signaling System / drug effects ; Male ; NF-kappa B / metabolism ; Neurons / drug effects ; Neurons / pathology ; Rats ; Rats, Sprague-Dawley ; Spatial Learning / drug effects ; Spatial Memory / drug effects Contributed Indexing: Keywords: Alzheimer’s disease; Excitotoxicity; Hippocampus; Ibotenic acid; Icariin; Rat Substance Nomenclature: 0 (Calbindins) ; 0 (Drugs, Chinese Herbal) ; 0 (Excitatory Amino Acid Agonists) ; 0 (Flavonoids) ; 0 (NF-kappa B) ; 0 (Neuroprotective Agents) ; 2552-55-8 (Ibotenic Acid) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20160703 Date Completed: 20171121 Latest Revision: 20190205 Update Code: 20240513

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Icariin, a major constituent from Epimedium brevicornum, attenuates ibotenic acid-induced excitotoxicity in rat hippocampus.