Metabolite Profiles of Icariin in Rat Feces, Bile and Urine by Ultraperformance Liquid-Chromatography/Quadrupole-Time-of-Flight Mass Spectrometry.

Sun, E ; Xu, F ; et al.

In: Journal of chromatographic science, Jg. 54 (2016-02-01), Heft 2, S. 158-64

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In this work, the metabolite profiles of icariin in rat feces, bile and urine were qualitatively investigated, and the possible metabolic pathways of icariin were subsequently proposed. After oral administration of icariin at a single dose of 100 mg/kg, rat biological samples were collected and pretreated. Then, these pretreated samples were detected by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS). In all, 17 metabolites were identified in the biosamples. Of these, 5, including F8-F9 (icariside I), D3-D4 (isopentenyl alcohol-icaritin-3-O-rha-7-O-gluA) and N3 (1,3-isoprene icariside II), were to our knowledge reported for the first time. The results indicated that icariin was metabolized via desugarization, dehydrogenation, hydroxylation, demethylation and glucuronidation pathways in vivo. This study revealed the possible metabolite profiles of icariin in rats.

Titel:	Metabolite Profiles of Icariin in Rat Feces, Bile and Urine by Ultraperformance Liquid-Chromatography/Quadrupole-Time-of-Flight Mass Spectrometry.
Autor/in / Beteiligte Person:	Sun, E ; Xu, F ; Qian, Q ; Cui, L ; Tan, X ; Jia, X
Link:	Zum Volltext
Zeitschrift:	Journal of chromatographic science, Jg. 54 (2016-02-01), Heft 2, S. 158-64
Veröffentlichung:	<2012- > : Oxford : Oxford University Press ; <i>Original Publication</i>: Niles Il : Preston Technical Abstracts, 2016
Medientyp:	academicJournal
ISSN:	1945-239X (electronic)
DOI:	10.1093/chromsci/bmv121
Schlagwort:	Animals Bile chemistry Drugs, Chinese Herbal administration & dosage Drugs, Chinese Herbal metabolism Flavonoids administration & dosage Flavonoids metabolism Flavonoids urine Male Rats Rats, Sprague-Dawley Bile metabolism Chromatography, High Pressure Liquid methods Drugs, Chinese Herbal chemistry Epimedium chemistry Feces chemistry Flavonoids chemistry Tandem Mass Spectrometry methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't Language: English [J Chromatogr Sci] 2016 Feb; Vol. 54 (2), pp. 158-64. MeSH Terms: Bile / metabolism ; Chromatography, High Pressure Liquid / methods ; Drugs, Chinese Herbal / chemistry ; Epimedium / chemistry ; Feces / chemistry ; Flavonoids / chemistry ; Tandem Mass Spectrometry / *methods ; Animals ; Bile / chemistry ; Drugs, Chinese Herbal / administration & dosage ; Drugs, Chinese Herbal / metabolism ; Flavonoids / administration & dosage ; Flavonoids / metabolism ; Flavonoids / urine ; Male ; Rats ; Rats, Sprague-Dawley Substance Nomenclature: 0 (Drugs, Chinese Herbal) ; 0 (Flavonoids) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20160122 Date Completed: 20161006 Latest Revision: 20191210 Update Code: 20231215

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