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Cerebral malaria (CM) is a neurological complication of infection with Plasmodium falciparum that is partly caused by cytokine-mediated inflammation. It is not known whether interleukin-17 (IL-17) cytokines, which regulate inflammation, control the development of CM. To evaluate the involvement of IL-17 cytokines in CM, we analyzed 46 common polymorphisms in IL17A, IL17F, and IL17RA (which encodes the common receptor chain of the members of the IL-17 family) in two independent African populations. A case-control study involving 115 Nigerian children with CM and 160 controls from the community (CC) showed that IL17F reference single nucleotide polymorphism (SNP) 6913472 (rs6913472) (P = 0.004; odds ratio [OR] = 3.12), IL17F rs4715291 (P = 0.004; OR = 2.82), IL17RA rs12159217 (P = 0.01; OR = 2.27), and IL17RA rs41396547 (P = 0.026; OR = 3.15) were independently associated with CM. A replication study was performed in 240 nuclear Malian family trios (two parents with one CM child). We replicated the association for 3 SNPs, IL17F rs6913472 (P = 0.03; OR = 1.39), IL17RA rs12159217 (P = 0.01; OR = 1.52), and IL17RA rs41396547 (P = 0.04; OR = 3.50). We also found that one additional SNP, IL17RA rs41433045, in linkage disequilibrium (LD) with rs41396547, was associated with CM in both Nigeria and Mali (P = 0.002; OR = 4.12 in the combined sample). We excluded the possibility that SNPs outside IL17F and IL17RA, in strong LD with the associated SNPs, could account for the observed associations. Furthermore, the results of a functional study indicated that the aggravating GA genotype of IL17F rs6913472 was associated with lower IL-17F concentrations. Our findings show for the first time that IL17F and IL17RA polymorphisms modulate susceptibility to CM and provide evidence that IL-17F protects against CM.

Titel:	The IL17F and IL17RA Genetic Variants Increase Risk of Cerebral Malaria in Two African Populations.
Autor/in / Beteiligte Person:	Marquet, S ; Conte, I ; Poudiougou, B ; Argiro, L ; Cabantous, S ; Dessein, H ; Burté, F ; Oumar, AA ; Brown, BJ ; Traore, A ; Afolabi, NK ; Barry, A ; Omokhodion, S ; Ndoumbe, UE ; Shokunbi, WA ; Sodeinde, O ; Doumbo, O ; Fernandez-Reyes, D ; Dessein, AJ
Link:	Zum Volltext
Zeitschrift:	Infection and immunity, Jg. 84 (2015-12-14), Heft 2, S. 590
Veröffentlichung:	Washington, DC : American Society For Microbiology ; <i>Original Publication</i>: [Bethesda, Md.] American Society for Microbiology., 2015
Medientyp:	academicJournal
ISSN:	1098-5522 (electronic)
DOI:	10.1128/IAI.00671-15
Schlagwort:	Adolescent Africa epidemiology Child Child, Preschool Computer Simulation Female Genetic Association Studies Genetic Predisposition to Disease Genetics, Population Genotype Humans Infant Interleukin-17 immunology Linkage Disequilibrium Malaria, Cerebral epidemiology Malaria, Cerebral immunology Male Receptors, Interleukin-17 immunology Interleukin-17 genetics Malaria, Cerebral ethnology Malaria, Cerebral genetics Polymorphism, Single Nucleotide Receptors, Interleukin-17 genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Infect Immun] 2015 Dec 14; Vol. 84 (2), pp. 590-7. <i>Date of Electronic Publication: </i>2015 Dec 14 (<i>Print Publication: </i>2016). MeSH Terms: Polymorphism, Single Nucleotide* ; Interleukin-17 / genetics ; Malaria, Cerebral / ethnology ; Malaria, Cerebral / genetics ; Receptors, Interleukin-17 / genetics ; Adolescent ; Africa / epidemiology ; Child ; Child, Preschool ; Computer Simulation ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetics, Population ; Genotype ; Humans ; Infant ; Interleukin-17 / immunology ; Linkage Disequilibrium ; Malaria, Cerebral / epidemiology ; Malaria, Cerebral / immunology ; Male ; Receptors, Interleukin-17 / immunology References: Trans R Soc Trop Med Hyg. 2000 Apr;94 Suppl 1:S1-90. (PMID: 11103309) ; Eur J Hum Genet. 2001 Apr;9(4):301-6. (PMID: 11313775) ; Am J Respir Cell Mol Biol. 2001 Sep;25(3):335-40. (PMID: 11588011) ; Genet Epidemiol. 2001;21 Suppl 1:S364-9. (PMID: 11793700) ; Genet Epidemiol. 2004 Apr;26(3):167-85. (PMID: 15022205) ; Nucleic Acids Res. 1998 Jan 1;26(1):362-7. (PMID: 9399875) ; Am J Hum Genet. 1998 Nov;63(5):1492-506. (PMID: 9792877) ; J Exp Med. 2005 Jan 17;201(2):233-40. (PMID: 15657292) ; J Infect Dis. 2005 Sep 1;192(5):854-60. (PMID: 16088835) ; J Exp Med. 2005 Sep 19;202(6):761-9. (PMID: 16157683) ; Curr Neurovasc Res. 2004 Apr;1(2):91-110. (PMID: 16185187) ; Nat Immunol. 2005 Nov;6(11):1133-41. (PMID: 16200068) ; J Allergy Clin Immunol. 2006 Apr;117(4):795-801. (PMID: 16630936) ; Am J Hum Genet. 2007 Sep;81(3):559-75. (PMID: 17701901) ; J Immunol. 2007 Oct 15;179(8):5462-73. (PMID: 17911633) ; Nat Med. 2007 Oct;13(10):1173-5. (PMID: 17828272) ; Nature. 2007 Oct 18;449(7164):851-61. (PMID: 17943122) ; Pediatr Infect Dis J. 2008 Feb;27(2):130-5. (PMID: 18174865) ; J Exp Med. 2008 May 12;205(5):1063-75. (PMID: 18411338) ; Hum Mol Genet. 2008 Jul 15;17(14):2190-5. (PMID: 18413324) ; Immunol Rev. 2008 Dec;226:57-79. (PMID: 19161416) ; Cytokine. 2009 Apr;46(1):7-11. (PMID: 19233684) ; Cell Res. 2009 Apr;19(4):399-411. (PMID: 19255592) ; Nat Rev Immunol. 2009 Aug;9(8):556-67. (PMID: 19575028) ; J Clin Invest. 2009 Aug;119(8):2379-87. (PMID: 19620772) ; J Infect Dis. 2009 Nov 15;200(10):1530-9. (PMID: 19835477) ; J Immunol. 2010 Apr 15;184(8):4307-16. (PMID: 20231694) ; Bioinformatics. 2010 Oct 1;26(19):2474-6. (PMID: 20702402) ; Nature. 2010 Oct 28;467(7319):1061-73. (PMID: 20981092) ; Biochem Biophys Res Commun. 2010 Nov 26;402(4):790-5. (PMID: 21036146) ; Nat Immunol. 2011 Mar;12(3):255-63. (PMID: 21278737) ; Immunity. 2011 Feb 25;34(2):149-62. (PMID: 21349428) ; Scand J Immunol. 2011 Jul;74(1):1-13. (PMID: 21338381) ; PLoS Pathog. 2012;8(4):e1002658. (PMID: 22577359) ; Malar J. 2012;11:336. (PMID: 23039275) ; PLoS One. 2012;7(12):e49778. (PMID: 23226502) ; Gene. 2013 Feb 15;515(1):229-32. (PMID: 23219503) ; Blood. 2013 Apr 11;121(15):3016-22. (PMID: 23380741) ; PLoS Pathog. 2014 Apr;10(4):e1004038. (PMID: 24743550) ; Trop Med Int Health. 2014 Sep;19 Suppl 1:7-131. (PMID: 25214480) Grant Information: D43 TW009112 United States TW FIC NIH HHS; MC_U117585869 United Kingdom MRC_ Medical Research Council Substance Nomenclature: 0 (IL17F protein, human) ; 0 (IL17RA protein, human) ; 0 (Interleukin-17) ; 0 (Receptors, Interleukin-17) Entry Date(s): Date Created: 20151216 Date Completed: 20160602 Latest Revision: 20220129 Update Code: 20231215 PubMed Central ID: PMC4730560

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The IL17F and IL17RA Genetic Variants Increase Risk of Cerebral Malaria in Two African Populations.