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Background: No previous meta-analysis was to report the association between the apolipoprotein B (APOB) XbaI and EcoRI polymorphisms and serum lipids in Chinese. We performed the study to investigate their potentially association.

Methods and Results: Studies in English and Chinese were found via a systematic search of Pubmed, Embase, CNKI and Wanfang databases. The dominant genetic model and random-effects model were used to pool data from individual studies. As a result, a total of 30 articles with 5611 subjects for XbaI and 2653 subjects for EcoRI were included in the current study. For the XbaI polymorphism, overall, subjects carrying X+ allele were significantly associated with higher TC,TG and LDL compared with X-X- genotype (Pvalue = 0.0006, OR (95 %) = -0.55 (-0.86,-0.23); Pvalue = 0.0004, OR (95 %) = -0.30 (-0.47,-0.14); (Pvalue = 0.05, OR (95 %) = -0.23(-0.46,-0.00), respectively). Similar results were observed in the subgroups of Han, healthy individuals (HT), coronary heart disease (CHD), cerebral infarction (CI), and cholelithiasis. For HDL, positive association between X+ allele with Lower lipid value was found in CHD and CI subgroups. For EcoRI polymorphism, overall, the E- allele carriers were found to be obviously linked with elevated LDL and lower HDL compared with E + E+ genotype (Pvalue = 0.02,OR (95 %) = -0.27 (-0.49,-0.05); Pvalue = 0.01, OR (95 %) = 0.17 (0.03, 0.30), respectively). TC was significantly high in subjects carrying E- allele in the subgroup of hyperlipidemia. No evidence of publication bias was observed.

Conclusions: The two genetic variants of APOB may be associated with serum lipids in Chinese.

Titel:	Association between the APOB XbaI and EcoRI polymorphisms and lipids in Chinese: a meta-analysis.
Autor/in / Beteiligte Person:	Gu, W ; Zhang, M ; Wen, S
Link:	Zum Volltext
Zeitschrift:	Lipids in health and disease, Jg. 14 (2015-10-07), S. 123
Veröffentlichung:	[London] : BioMed Central, 2002-, 2015
Medientyp:	academicJournal
ISSN:	1476-511X (electronic)
DOI:	10.1186/s12944-015-0125-z
Schlagwort:	Alleles Apolipoproteins B blood Asian People Case-Control Studies Cerebral Infarction blood Cerebral Infarction ethnology Cerebral Infarction pathology Cholelithiasis blood Cholelithiasis ethnology Cholelithiasis pathology Cholesterol, HDL blood Cholesterol, LDL blood Coronary Disease blood Coronary Disease ethnology Coronary Disease pathology Deoxyribonuclease EcoRI chemistry Deoxyribonucleases, Type II Site-Specific chemistry Gene Frequency Genotype Humans Hyperlipidemias blood Hyperlipidemias ethnology Hyperlipidemias pathology Triglycerides blood Apolipoproteins B genetics Cerebral Infarction genetics Cholelithiasis genetics Coronary Disease genetics Hyperlipidemias genetics Polymorphism, Single Nucleotide
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Language: English [Lipids Health Dis] 2015 Oct 07; Vol. 14, pp. 123. <i>Date of Electronic Publication: </i>2015 Oct 07. MeSH Terms: Polymorphism, Single Nucleotide* ; Apolipoproteins B / genetics ; Cerebral Infarction / genetics ; Cholelithiasis / genetics ; Coronary Disease / genetics ; Hyperlipidemias / *genetics ; Alleles ; Apolipoproteins B / blood ; Asian People ; Case-Control Studies ; Cerebral Infarction / blood ; Cerebral Infarction / ethnology ; Cerebral Infarction / pathology ; Cholelithiasis / blood ; Cholelithiasis / ethnology ; Cholelithiasis / pathology ; Cholesterol, HDL / blood ; Cholesterol, LDL / blood ; Coronary Disease / blood ; Coronary Disease / ethnology ; Coronary Disease / pathology ; Deoxyribonuclease EcoRI / chemistry ; Deoxyribonucleases, Type II Site-Specific / chemistry ; Gene Frequency ; Genotype ; Humans ; Hyperlipidemias / blood ; Hyperlipidemias / ethnology ; Hyperlipidemias / pathology ; Triglycerides / blood References: Genet Epidemiol. 1992;9(1):1-10. (PMID: 1353045) ; J Lipid Res. 1990 Jan;31(1):71-7. (PMID: 1968951) ; Clin Chem. 1995 Mar;41(3):424-9. (PMID: 7533671) ; Chin Med Sci J. 2003 Mar;18(1):9-13. (PMID: 12901521) ; Biometrics. 1994 Dec;50(4):1088-101. (PMID: 7786990) ; Atherosclerosis. 2004 Mar;173(1):89-96. (PMID: 15177127) ; Zhonghua Yi Xue Za Zhi. 1999 Aug;79(8):603-6. (PMID: 11715409) ; Science. 1986 Apr 4;232(4746):34-47. (PMID: 3513311) ; Hum Genet. 1993 Sep;92(2):191-7. (PMID: 8370587) ; Atherosclerosis. 1995 Sep;117(1):43-50. (PMID: 8546754) ; Clin Genet. 2000 Apr;57(4):304-8. (PMID: 10845572) ; World J Gastroenterol. 2010 May 28;16(20):2549-53. (PMID: 20503456) ; J Cardiovasc Med (Hagerstown). 2014 Sep;15(9):717-26. (PMID: 25083581) ; Physiol Res. 2001;50(4):337-43. (PMID: 11551138) ; Chin Med J (Engl). 1994 Jan;107(1):30-5. (PMID: 7910546) ; Clin Biochem Rev. 2004 Feb;25(1):2. (PMID: 18516207) ; Neurol India. 2009 Sep-Oct;57(5):584-8. (PMID: 19934556) ; Hum Genet. 2003 Oct;113(5):417-25. (PMID: 12942366) ; J Clin Invest. 1988 Sep;82(3):797-802. (PMID: 2901432) ; N Engl J Med. 1993 Apr 22;328(16):1150-6. (PMID: 8455681) ; Clin Genet. 2002 Feb;61(2):126-34. (PMID: 11940087) ; Clin Genet. 1992 Oct;42(4):164-70. (PMID: 1358487) ; Ann Hum Biol. 2009 Jul-Aug;36(4):411-20. (PMID: 19449275) ; Asian Pac J Trop Med. 2014 Jan;7(1):63-6. (PMID: 24418085) ; Int J Neurosci. 2016 Jul;126(7):584-92. (PMID: 26004908) ; BMJ. 1997 Sep 13;315(7109):629-34. (PMID: 9310563) ; Zhonghua Yi Xue Za Zhi. 2008 Dec 23;88(47):3332-6. (PMID: 19257963) ; Atherosclerosis. 1988 Nov;74(1-2):47-54. (PMID: 2905601) ; Zhonghua Yi Xue Za Zhi. 2003 May 25;83(10):844-7. (PMID: 12895336) ; PLoS One. 2013;8(4):e61456. (PMID: 23637837) ; Proc Natl Acad Sci U S A. 1986 Oct;83(19):7367-70. (PMID: 2876424) ; Wei Sheng Yan Jiu. 2001 Sep;30(5):280-2. (PMID: 12561593) ; Ann Intern Med. 1997 Nov 1;127(9):820-6. (PMID: 9382404) Substance Nomenclature: 0 (Apolipoproteins B) ; 0 (Cholesterol, HDL) ; 0 (Cholesterol, LDL) ; 0 (Triglycerides) ; EC 3.1.21.- (Deoxyribonuclease EcoRI) ; EC 3.1.21.- (endodeoxyribonuclease XBAI) ; EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific) Entry Date(s): Date Created: 20151009 Date Completed: 20160518 Latest Revision: 20221207 Update Code: 20231215 PubMed Central ID: PMC4596460

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Association between the APOB XbaI and EcoRI polymorphisms and lipids in Chinese: a meta-analysis.