Inhibition of Acetylcholinesterase (AChE): A Potential Therapeutic Target to Treat Alzheimer's Disease.
In: Chemical biology & drug design, Jg. 86 (2015-10-01), Heft 4, S. 776-82
Online
academicJournal
Zugriff:
A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. Most of the tested compounds exhibited high AChE inhibition and low toxicity, and among which compounds 1, 2, and 10 were the most potent (IC50 = 71.52 ± 22.43, 8.28 ± 1.45, 5.830 ± 1.78 nm, respectively).
(© 2015 John Wiley & Sons A/S.)
Titel: |
Inhibition of Acetylcholinesterase (AChE): A Potential Therapeutic Target to Treat Alzheimer's Disease.
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Autor/in / Beteiligte Person: | Li, Y ; Zhang, XX ; Jiang, LJ ; Yuan, L ; Cao, TT ; Li, X ; Dong, L ; Yin, SF |
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Zeitschrift: | Chemical biology & drug design, Jg. 86 (2015-10-01), Heft 4, S. 776-82 |
Veröffentlichung: | Oxford : Wiley-Blackwell, 2006-, 2015 |
Medientyp: | academicJournal |
ISSN: | 1747-0285 (electronic) |
DOI: | 10.1111/cbdd.12550 |
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