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The aim of the study was to investigate the effect of icariin (ICA) on cardiac aging through its effects on the SIRT6 enzyme and on the NF-κB pathway. Investigating the effect of ICA on the enzymatic activity of histone deacetylase SIRT6 revealed a concentration of 10(-8) mol/L ICA had a maximum activating effect on histone deacetylase SIRT6 enzymatic activity. Western analysis showed that ICA upregulated SIRT6 protein expression and downregulated NF-κB (p65) protein expression in animal tissues and cell models. ICA upregulated the expression of SIRT6 and had an inhibitory effect on NF-κB inflammatory signaling pathways as shown by decreasing mRNA levels of the NF-κB downstream target genes TNF-α, ICAM-1, IL-2, and IL-6. Those effects were mediated directly or indirectly by SIRT6. We provided evidence that inflammaging may involve a novel link between the effects of ICA on SIRT6 (a regulator of aging) and NF-κB (a regulator of inflammation).

Titel:	Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway.
Autor/in / Beteiligte Person:	Chen, Y ; Sun, T ; Wu, J ; Kalionis, B ; Zhang, C ; Yuan, D ; Huang, J ; Cai, W ; Fang, H ; Xia, S
Link:	Zum Volltext
Zeitschrift:	BioMed research international, Jg. 2015 (2015), S. 895976
Veröffentlichung:	New York, NY : Hindawi Pub. Co., 2015
Medientyp:	academicJournal
ISSN:	2314-6141 (electronic)
DOI:	10.1155/2015/895976
Schlagwort:	Analysis of Variance Animals Cells, Cultured Cellular Senescence drug effects Drugs, Chinese Herbal pharmacology Endothelial Cells cytology Gene Expression drug effects Male Mice Mice, Inbred BALB C NF-kappa B analysis NF-kappa B genetics Sirtuins analysis Sirtuins genetics Cardiovascular Agents pharmacology Flavonoids pharmacology NF-kappa B metabolism Signal Transduction drug effects Sirtuins metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Biomed Res Int] 2015; Vol. 2015, pp. 895976. <i>Date of Electronic Publication: </i>2015 Jan 20. MeSH Terms: Cardiovascular Agents / pharmacology ; Flavonoids / pharmacology ; NF-kappa B / metabolism ; Signal Transduction / drug effects ; Sirtuins / *metabolism ; Analysis of Variance ; Animals ; Cells, Cultured ; Cellular Senescence / drug effects ; Drugs, Chinese Herbal / pharmacology ; Endothelial Cells / cytology ; Gene Expression / drug effects ; Male ; Mice ; Mice, Inbred BALB C ; NF-kappa B / analysis ; NF-kappa B / genetics ; Sirtuins / analysis ; Sirtuins / genetics References: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Dec;24(12):1094-7. (PMID: 15658653) ; Trends Immunol. 2005 Feb;26(2):79-84. (PMID: 15668122) ; Trends Biochem Sci. 2011 Jan;36(1):39-46. (PMID: 20729089) ; Nutr Rev. 2007 Dec;65(12 Pt 2):S173-6. (PMID: 18240544) ; Curr Drug Targets. 2010 Oct;11(10):1270-80. (PMID: 20840069) ; Oncogene. 2013 Oct 24;32(43):5144-55. (PMID: 23178493) ; Nature. 2008 Mar 27;452(7186):492-6. (PMID: 18337721) ; Science. 2010 Sep 10;329(5997):1348-53. (PMID: 20829486) ; Mech Ageing Dev. 2007 Jan;128(1):92-105. (PMID: 17116321) ; PLoS One. 2011;6(12):e28835. (PMID: 22216122) ; Cell Metab. 2010 Sep 8;12(3):224-36. (PMID: 20816089) ; Cell. 2006 Jan 27;124(2):315-29. (PMID: 16439206) ; J Med Genet. 2003 Apr;40(4):296-9. (PMID: 12676903) ; Molecules. 2010 Nov 03;15(11):7861-70. (PMID: 21060294) ; Cell Mol Life Sci. 2008 Apr;65(7-8):1049-58. (PMID: 18193389) ; Mech Ageing Dev. 2009 Jan-Feb;130(1-2):40-5. (PMID: 18671998) ; Cell. 2009 Jan 9;136(1):19-21. (PMID: 19135883) ; Exp Mol Pathol. 2006 Jun;80(3):219-27. (PMID: 16460728) ; Hypertension. 1998 Oct;32(4):718-23. (PMID: 9774369) ; Curr Pharm Des. 2006;12(24):3161-71. (PMID: 16918441) ; Cell. 2009 Jan 9;136(1):62-74. (PMID: 19135889) ; Biochem Biophys Res Commun. 1999 Jun 24;260(1):273-9. (PMID: 10381378) ; Mech Ageing Dev. 2007 Jan;128(1):83-91. (PMID: 17118425) ; Biochem Biophys Res Commun. 2000 Jul 5;273(2):793-8. (PMID: 10873683) ; Mech Ageing Dev. 2008 Oct;129(10):614-23. (PMID: 18789959) ; Crit Care Med. 2000 Apr;28(4 Suppl):N100-4. (PMID: 10807322) ; Mol Biosyst. 2009 Oct;5(10):1204-13. (PMID: 19756310) ; Guang Pu Xue Yu Guang Pu Fen Xi. 2008 Jan;28(1):55-60. (PMID: 18422119) ; J Am Coll Cardiol. 2000 Oct;36(4):1396-403. (PMID: 11028501) ; J Biol Chem. 2010 Nov 19;285(47):36776-84. (PMID: 20847051) ; Ann N Y Acad Sci. 2000 Jun;908:244-54. (PMID: 10911963) ; Mol Biosyst. 2008 Aug;4(8):855-61. (PMID: 18633487) ; Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Jun;28(6):522-5. (PMID: 18655561) ; FEBS Lett. 2005 Apr 11;579(10):2035-9. (PMID: 15811314) ; J Intern Med. 2008 Feb;263(2):128-41. (PMID: 18226091) ; Ann Rheum Dis. 2010 Jul;69(7):1315-20. (PMID: 20448286) Substance Nomenclature: 0 (Cardiovascular Agents) ; 0 (Drugs, Chinese Herbal) ; 0 (Flavonoids) ; 0 (NF-kappa B) ; EC 2.4.2.31 (Sirt6 protein, mouse) ; EC 3.5.1.- (Sirtuins) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20150218 Date Completed: 20150928 Latest Revision: 20200306 Update Code: 20231215 PubMed Central ID: PMC4320867

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Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway.