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Objective: To assess extent and determinants of past-month recognition of suspected adverse drug reactions (ADR) and past-year ADR reporting among healthcare professionals (HCPs) in Uganda.

Setting: Geographically diverse health facilities (public, private for-profit, private not-for-profit).

Participants: Of 2000 questionnaires distributed, 1345 were completed: return rate of 67%.

Primary and Secondary Outcome Measures: Per cent HCPs who suspected ADR in the past month; reported ADR in the past year.

Results: Nurses were the majority (59%, 792/1345). Only half the respondents had heard about pharmacovigilance: 39% of nurses (295/763; 95% CI 35% to 42%), 70% otherwise (383/547; 95% CI 66% to 74%). One fifth (268/1289 or 21%; 95% CI 19% to 23%) had suspected an ADR in the previous 4 weeks, 111 of them were nurses; 15% (190/1296) had reported a suspected ADR in the past year, 103 of them were nurses. Past-month ADR suspicion was more likely by non-nurses (OR=1.7, 95% CI 1.16 to 2.40) and with medical research involvement (OR=1.5, 95% CI 1.05 to 2.15) but past-month receipt of patient ADR-complaint predominated (OR=19, 95% CI 14 to 28). Past-year ADR reporting was higher by hospital staff (OR=1.9, 95% CI 1.18 to 3.10), especially in medicine (OR=2.3, 95% CI 1.08 to 4.73); but lower from private for-profit health facilities (OR=0.5, 95% CI 0.28 to 0.77) and by older staff (OR=0.6, 95% CI 0.43 to 0.91); more likely by HCPs who had ever encountered a fatal ADR (OR=2.9, 95% CI 1.94 to 4.25), knew to whom to report (OR=1.7, 95% CI 1.18 to 2.46), or suggested how to improve ADR reporting (OR=1.6, 95% CI 1.04 to 2.49). Two attitudinal factors were important: diffidence and lethargy.

Conclusions: One in five HCPs suspected an ADR in the past-month and one in seven reported ADR in the previous year. Empowering patients could strengthen ADR detection and reporting in Africa.

(Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)

Titel:	Recognition and reporting of suspected adverse drug reactions by surveyed healthcare professionals in Uganda: key determinants.
Autor/in / Beteiligte Person:	Kiguba, R ; Karamagi, C ; Waako, P ; Ndagije, HB ; Bird, SM
Link:	Zum Volltext
Zeitschrift:	BMJ open, Jg. 4 (2014-11-24), Heft 11, S. e005869
Veröffentlichung:	[London] : BMJ Publishing Group Ltd, 2011-, 2014
Medientyp:	academicJournal
ISSN:	2044-6055 (electronic)
DOI:	10.1136/bmjopen-2014-005869
Schlagwort:	Adult Cross-Sectional Studies Female Humans Male Uganda Adverse Drug Reaction Reporting Systems statistics & numerical data Health Personnel Pharmacovigilance Surveys and Questionnaires
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [BMJ Open] 2014 Nov 24; Vol. 4 (11), pp. e005869. <i>Date of Electronic Publication: </i>2014 Nov 24. MeSH Terms: Health Personnel* ; Pharmacovigilance* ; Surveys and Questionnaires* ; Adverse Drug Reaction Reporting Systems / *statistics & numerical data ; Adult ; Cross-Sectional Studies ; Female ; Humans ; Male ; Uganda References: BMC Clin Pharmacol. 2009;9:14. (PMID: 19671176) ; Br J Clin Pharmacol. 2011 Jul;72(1):143-52. (PMID: 21332572) ; CMAJ. 2013 Jul 9;185(10):866. (PMID: 23695608) ; Br J Clin Pharmacol. 1996 May;41(5):434-5. (PMID: 8735689) ; J Clin Pharm Ther. 2004 Feb;29(1):31-5. (PMID: 14748895) ; BMJ. 2009;338:b2393. (PMID: 19564179) ; J Eval Clin Pract. 2004 Nov;10(4):483-9. (PMID: 15482410) ; CMAJ. 2006 Jan 17;174(2):191-2. (PMID: 16415466) ; Drug Saf. 2009;32(10):851-8. (PMID: 19722728) ; Drug Saf. 2005;28(9):825-33. (PMID: 16119975) ; Pharmacoepidemiol Drug Saf. 1998 Sep;7(5):323-9. (PMID: 15073979) ; J Nat Sci Biol Med. 2013 Jan;4(1):191-6. (PMID: 23633861) ; Indian J Med Sci. 2012 Mar-Apr;66(3-4):55-61. (PMID: 23603621) ; Drug Saf. 2009;32(1):19-31. (PMID: 19132802) ; Qual Saf Health Care. 2010 Apr;19(2):144-7. (PMID: 20351163) ; Drug Saf. 2006;29(5):385-96. (PMID: 16689555) ; Drug Saf. 2007;30(11):1073-82. (PMID: 17973543) ; Drug Saf. 2006;29(7):641-2. (PMID: 16808556) ; BMJ. 1998 Apr 25;316(7140):1295-8. (PMID: 9554902) ; Pharmacoepidemiol Drug Saf. 2013 Jan;22(1):98-102. (PMID: 23027707) ; Br J Clin Pharmacol. 1992 Nov;34(5):421-6. (PMID: 1467137) ; Pharmacoepidemiol Drug Saf. 2010 Feb;19(2):191-5. (PMID: 20014358) ; Ther Adv Drug Saf. 2012 Feb;3(1):25-34. (PMID: 25083223) ; Trop Med Int Health. 2008 Sep;13(9):1143-52. (PMID: 18631312) ; Cent Afr J Med. 1998 Aug;44(8):190-5. (PMID: 10101417) ; Drug Saf. 2012 Dec 1;35(12):1171-82. (PMID: 23072620) ; JAMA. 2003 Feb 26;289(8):1001-7. (PMID: 12597752) ; Chin Med J (Engl). 2004 Jun;117(6):856-61. (PMID: 15198887) ; Expert Opin Pharmacother. 2003 Mar;4(3):319-26. (PMID: 12614184) ; Drug Saf. 2006;29(4):331-40. (PMID: 16569082) ; Pharmacoepidemiol Drug Saf. 2008 May;17(5):517-22. (PMID: 18404621) ; JAMA. 1997 Jan 22-29;277(4):307-11. (PMID: 9002493) ; Br J Clin Pharmacol. 1996 Oct;42(4):423-9. (PMID: 8904613) ; Med Care. 1999 Aug;37(8):809-14. (PMID: 10448723) ; JAMA. 1998 Apr 15;279(15):1200-5. (PMID: 9555760) ; S Afr Med J. 1987 Jul 18;72(2):131-4. (PMID: 3616786) ; JAMA. 1997 Jan 22-29;277(4):301-6. (PMID: 9002492) ; J R Coll Physicians Lond. 1995 Jan-Feb;29(1):41-9. (PMID: 7738878) ; CMAJ. 2012 Jul 10;184(10):E533-4. (PMID: 22690007) ; Pharmacoepidemiol Drug Saf. 2011 Dec;20(12):1303-10. (PMID: 21735508) ; Pharmacoepidemiol Drug Saf. 2003 Dec;12(8):687-92. (PMID: 14762985) Grant Information: R24 TW008886 United States TW FIC NIH HHS; 087540 United Kingdom WT_ Wellcome Trust; 5R24TW008886 United States TW FIC NIH HHS; 100891 United Kingdom WT_ Wellcome Trust; MC_U105260794 United Kingdom MRC_ Medical Research Council Contributed Indexing: Keywords: Adverse Drug Reactions; Healthcare Professionals; Pharmacoviligance; Reporting-Rates; Uganda Entry Date(s): Date Created: 20141126 Date Completed: 20150702 Latest Revision: 20220331 Update Code: 20231215 PubMed Central ID: PMC4244492

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Recognition and reporting of suspected adverse drug reactions by surveyed healthcare professionals in Uganda: key determinants.