[Comparison research with icariin and genistein by anti-inflammatory reaction and angiogenesis pathway to inhibit bone loss on ovariectomized rats].

Cheng, K ; Chen, KM ; et al.

In: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, Jg. 37 (2014-04-01), Heft 4, S. 627

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Objective: Through researching the relationship among osteoporosis and inflammatory reaction besides angiogenesis, to compare pharmacological differences between icariin and genistein to inhibit bone loss.

Methods: 6 months old female SD rats were randomly divided into SHAM group, model group, ICA group, GEN group and E group. The bone mineral density of total, femur and lumbar, serum OC, TRACP 5b, IL-6 and VEGF, biomechanics of femur and tibia microarchitecture were analyzed.

Results: Compared with SHAM group, model group of body weight, uterine weight, bone mineral density of total, femur and lumbar, serum OC, TRACP 5b, IL-6 and VEGF, biomechanics of femur and lumbar and tibia microarchitecture were significantly changed (P < 0.05). Compared with model group, ICA group of body weight, bone mineral density of total and femur, serum TRACP 5b and femural biomechanics were significantly changed (P < 0.05). GEN group of bone mineral density of total, femur and lumbar, serum OC, TRACP 5b, IL-6 and VEGF, biomechanics of femur and lumbar and tibia microarchitecture were significantly changed (P < 0.05).

Conclusion: Icariin inhibits bone loss on model rat through suppressing bone resorption. Genistein prevents bone loss on model rat by the pathway of inhibiting inflammatory reaction, activating angiogenesis, enhancing bone formation and inhibiting bone resorption. Moreover, pharmacological activity of genistein is more potential than icariin.

Titel:	[Comparison research with icariin and genistein by anti-inflammatory reaction and angiogenesis pathway to inhibit bone loss on ovariectomized rats].
Autor/in / Beteiligte Person:	Cheng, K ; Chen, KM ; Ge, BF ; Zhen, P ; Gao, YH ; Ma, HP
Link:	Zum Volltext
Zeitschrift:	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, Jg. 37 (2014-04-01), Heft 4, S. 627
Veröffentlichung:	Guangzhou Shi : Guo jia yi yao guan li ju Zhong yao cai qing bao zhong xin zhan ; <i>Original Publication</i>: Guangzhou Shi : Guo jia yi yao guan li ju Zhong yao cai qing bao zhong xin zhan,, 2014
Medientyp:	academicJournal
ISSN:	1001-4454 (print)
Schlagwort:	Acid Phosphatase blood Administration, Oral Angiogenesis Inducing Agents pharmacology Animals Anti-Inflammatory Agents pharmacology Bone Resorption pathology Bone and Bones drug effects Bone and Bones pathology Epimedium chemistry Fabaceae chemistry Female Interleukin-6 blood Isoenzymes blood Osteocalcin blood Osteoporosis etiology Osteoporosis prevention & control Ovariectomy Random Allocation Rats Rats, Sprague-Dawley Tartrate-Resistant Acid Phosphatase Vascular Endothelial Growth Factor A blood Bone Density drug effects Bone Density Conservation Agents pharmacology Bone Resorption prevention & control Flavonoids pharmacology Genistein pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Chinese Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Language: Chinese [Zhong Yao Cai] 2014 Apr; Vol. 37 (4), pp. 627-31. MeSH Terms: Bone Density / drug effects ; Bone Density Conservation Agents / pharmacology ; Bone Resorption / prevention & control ; Flavonoids / pharmacology ; Genistein / *pharmacology ; Acid Phosphatase / blood ; Administration, Oral ; Angiogenesis Inducing Agents / pharmacology ; Animals ; Anti-Inflammatory Agents / pharmacology ; Bone Resorption / pathology ; Bone and Bones / drug effects ; Bone and Bones / pathology ; Epimedium / chemistry ; Fabaceae / chemistry ; Female ; Interleukin-6 / blood ; Isoenzymes / blood ; Osteocalcin / blood ; Osteoporosis / etiology ; Osteoporosis / prevention & control ; Ovariectomy ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Tartrate-Resistant Acid Phosphatase ; Vascular Endothelial Growth Factor A / blood Substance Nomenclature: 0 (Angiogenesis Inducing Agents) ; 0 (Anti-Inflammatory Agents) ; 0 (Bone Density Conservation Agents) ; 0 (Flavonoids) ; 0 (Interleukin-6) ; 0 (Isoenzymes) ; 0 (Vascular Endothelial Growth Factor A) ; 0 (vascular endothelial growth factor A, rat) ; 104982-03-8 (Osteocalcin) ; DH2M523P0H (Genistein) ; EC 3.1.3.2 (Acid Phosphatase) ; EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20141028 Date Completed: 20150108 Latest Revision: 20161125 Update Code: 20231215

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