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A variety of recent data demonstrate that vasoactive intestinal polypeptide (VIP) and VPAC receptors (which bind VIP, and to a lesser extent, pituitary adenylatecyclase activating peptide) are important for numerous social behaviors in songbirds, including grouping and aggression, although VIP relates to these behaviors in a site-specific manner. In order to determine the global effects of central VPAC receptor activation on social behavior, we here infused a VPAC receptor antagonist or vehicle twice daily into the lateral ventricle of colony-housed male and female zebra finches and quantified a wide range of behaviors. Aggressive behaviors were not altered by ventricular infusions, consistent with known opposing, site-specific relationships of VIP innervation to aggression. Courtship and self-maintenance behaviors were likewise not altered. However, VPAC antagonism produced significant deficits in pair bonding. Antagonist subjects took longer to form a pair bond and were paired for significantly fewer observation sessions relative to control subjects (median 1.5 of 6 observation sessions for antagonist subjects versus 4 for control subjects). Antagonist subjects were also significantly less likely to be paired in the final observation session. Based on the known distribution of VPAC receptors in finches and other vertebrates, we propose that VPAC receptors may mediate pair bonding via a variety of brain areas that are known to be important for the establishment of partner preferences in voles, including the lateral septum, ventral tegmental area, nucleus accumbens and ventral pallidum.

Titel:	Pair bond formation is impaired by VPAC receptor antagonism in the socially monogamous zebra finch.
Autor/in / Beteiligte Person:	Kingsbury, MA ; Goodson, JL
Link:	Zum Volltext
Zeitschrift:	Behavioural brain research, Jg. 272 (2014-10-01), S. 264
Veröffentlichung:	Amsterdam, Elsevier/North-Holland Biomedical Press., 2014
Medientyp:	academicJournal
ISSN:	1872-7549 (electronic)
DOI:	10.1016/j.bbr.2014.06.042
Schlagwort:	Aggression drug effects Aggression physiology Animals Avian Proteins metabolism Behavior, Animal drug effects Behavior, Animal physiology Brain drug effects Catheters, Indwelling Courtship Female Male Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide metabolism Time Factors Vasoactive Intestinal Peptide metabolism Avian Proteins antagonists & inhibitors Brain physiology Finches physiology Pair Bond Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide antagonists & inhibitors
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural Language: English [Behav Brain Res] 2014 Oct 01; Vol. 272, pp. 264-8. <i>Date of Electronic Publication: </i>2014 Jul 08. MeSH Terms: Pair Bond* ; Avian Proteins / antagonists & inhibitors ; Brain / physiology ; Finches / physiology ; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide / antagonists & inhibitors ; Aggression / drug effects ; Aggression / physiology ; Animals ; Avian Proteins / metabolism ; Behavior, Animal / drug effects ; Behavior, Animal / physiology ; Brain / drug effects ; Catheters, Indwelling ; Courtship ; Female ; Male ; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide / metabolism ; Time Factors ; Vasoactive Intestinal Peptide / metabolism References: Proc Biol Sci. 2013 Jan 7;280(1750):20122396. (PMID: 23173212) ; Horm Behav. 2012 Jul;62(2):113-9. (PMID: 22633910) ; Horm Behav. 2009 Jun;56(1):101-7. (PMID: 19341739) ; Behav Neurosci. 2012 Feb;126(1):97-109. (PMID: 22141469) ; Nat Neurosci. 2004 Oct;7(10):1048-54. (PMID: 15452576) ; Nat Neurosci. 2006 Jan;9(1):133-9. (PMID: 16327783) ; J Physiol. 1987 Jul;388:285-94. (PMID: 3656194) ; J Mol Neurosci. 2007;31(3):183-200. (PMID: 17726225) ; Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13847-52. (PMID: 22872869) ; Behav Neurosci. 2001 Aug;115(4):910-9. (PMID: 11508730) ; Exp Neurol. 2007 Jul;206(1):101-13. (PMID: 17521630) ; Science. 2011 Jul 15;333(6040):353-7. (PMID: 21764750) ; J Comp Neurol. 2004 Aug 30;476(4):388-413. (PMID: 15282712) ; Horm Behav. 2004 Feb;45(2):136-43. (PMID: 15019801) ; Mol Biol Evol. 2010 Jun;27(6):1269-78. (PMID: 20097658) ; Physiol Behav. 2005 Oct 15;86(3):338-46. (PMID: 16165168) ; PLoS One. 2011;6(6):e20720. (PMID: 21694758) ; Front Neuroendocrinol. 2011 Jan;32(1):53-69. (PMID: 20688099) ; Horm Behav. 2013 Aug;64(3):511-8. (PMID: 23899763) ; Proc Natl Acad Sci U S A. 2012 Jun 26;109 Suppl 1:10685-92. (PMID: 22723363) ; J Mol Neurosci. 2003 Apr;20(2):163-72. (PMID: 12794310) ; J Comp Neurol. 1997 Apr 28;381(1):101-18. (PMID: 9087422) ; Horm Behav. 2006 Aug;50(2):223-36. (PMID: 16643915) ; Endocrinology. 2011 Dec;152(12):4865-81. (PMID: 22067316) ; Exp Brain Res. 1988;72(3):523-34. (PMID: 2466680) Grant Information: R01 MH092331 United States MH NIMH NIH HHS; MH092331 United States MH NIMH NIH HHS Contributed Indexing: Keywords: Bird; Monogamy; Vasoactive intestinal polypeptide Substance Nomenclature: 0 (Avian Proteins) ; 0 (Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide) ; 37221-79-7 (Vasoactive Intestinal Peptide) Entry Date(s): Date Created: 20140712 Date Completed: 20150716 Latest Revision: 20211021 Update Code: 20240513 PubMed Central ID: PMC4172296

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Pair bond formation is impaired by VPAC receptor antagonism in the socially monogamous zebra finch.