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Introduction: The impaired erectile response in spontaneously hypertensive rats (SHR) is caused by increased signaling of RhoA/Rho-kinase and decreased signaling of nitric oxide (NO). Icariin improves erectile function via upregulating multitargets in NO/cyclic guanosine monophosphate (NO/cGMP) pathway, which breviscapine accomplishes by downregulating RhoA/Rho-kinase pathway.

Aim: To investigate the effect and mechanism of icariin combined with breviscapine on the erectile function of SHR.

Methods: Five 12-week-old male Wistar-Kyoto (WKY) rats and 20 age-matched male SHR were evenly randomized into WKY rats control group, SHR control group, icariin-treated group, breviscapine-treated group, and combined treatment group treated by vehicle, icariin, breviscapine, and icariin plus breviscapine, respectively, by gavage for four successive weeks. Maximum intracavernosal pressure/mean arterial pressure (ICPmax/MAP) and the expression of endothelial nitric oxide synthase (eNOS), neuronal nitric oxide synthase (nNOS), phosphodiesterase type 5 inhibitors (PDE5), and Rho-associated, coiled-coil containing protein kinase 1 and 2 (ROCK1 and ROCK2) in the cavernous tissues were determined.

Results: The ICPmax/MAP in the combined treatment group was significantly increased compared with SHR control group, icariin-treated group, and breviscapine-treated group. The expression of eNOS and nNOS was significantly higher in the combined treatment group than in SHR control group, icariin-treated group, and breviscapine-treated group (P < 0.05). The expression of PDE5 was significantly lower in the icariin-treated group than in SHR control group (P < 0.05). The expression of ROCK1 was significantly lower in the combined treatment group than in other groups (P < 0.05). The expression of ROCK2 was significantly higher in SHR control group than in WKY rats control group, icariin-treated group, and combined treatment group (P < 0.05). Among these groups, the expression of eNOS and nNOS was the strongest, and ROCK1 was the lowest in WKY rats control group.

Conclusion: Icariin combined with breviscapine has synergistic effects on erectile function of SHR through different signal pathways.

Titel:	Icariin combined with breviscapine improves the erectile function of spontaneously hypertensive rats.
Autor/in / Beteiligte Person:	Li, Y ; Jiang, J ; He, Y ; Jiang, R ; Liu, J ; Fan, Z ; Cheng, Y
Zeitschrift:	The journal of sexual medicine, Jg. 11 (2014-09-01), Heft 9, S. 2143
Veröffentlichung:	2023- : [Oxford] : Oxford University Press ; <i>Original Publication</i>: Malden, MA : Blackwell Pub., 2014
Medientyp:	academicJournal
ISSN:	1743-6109 (electronic)
DOI:	10.1111/jsm.12614
Schlagwort:	Animals Cyclic Nucleotide Phosphodiesterases, Type 5 metabolism Drug Therapy, Combination Male Nitric Oxide Synthase Type I metabolism Nitric Oxide Synthase Type III metabolism Penis drug effects Penis enzymology Penis metabolism Rats Rats, Inbred SHR Rats, Inbred WKY rho-Associated Kinases metabolism Drugs, Chinese Herbal administration & dosage Flavonoids administration & dosage Penile Erection drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [J Sex Med] 2014 Sep; Vol. 11 (9), pp. 2143-52. <i>Date of Electronic Publication: </i>2014 Jun 10. MeSH Terms: Drugs, Chinese Herbal / administration & dosage ; Flavonoids / administration & dosage ; Penile Erection / *drug effects ; Animals ; Cyclic Nucleotide Phosphodiesterases, Type 5 / metabolism ; Drug Therapy, Combination ; Male ; Nitric Oxide Synthase Type I / metabolism ; Nitric Oxide Synthase Type III / metabolism ; Penis / drug effects ; Penis / enzymology ; Penis / metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; rho-Associated Kinases / metabolism Contributed Indexing: Keywords: Breviscapine; Erectile Dysfunction; Erectile Function; Hypertension; Icariin; Rat Substance Nomenclature: 0 (Drugs, Chinese Herbal) ; 0 (Flavonoids) ; 116122-36-2 (breviscapine) ; EC 1.14.13.39 (Nitric Oxide Synthase Type I) ; EC 1.14.13.39 (Nitric Oxide Synthase Type III) ; EC 2.7.11.1 (ROCK1 protein, rat) ; EC 2.7.11.1 (ROCK2 protein, rat) ; EC 2.7.11.1 (rho-Associated Kinases) ; EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 5) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20140611 Date Completed: 20150121 Latest Revision: 20181202 Update Code: 20231215

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Icariin combined with breviscapine improves the erectile function of spontaneously hypertensive rats.