Mapping of monoclonal antibodies to human factor IX.
In: Blood, Jg. 74 (1989-08-15), Heft 3, S. 971
academicJournal
Zugriff:
We used recombinant DNA techniques to map a panel of six monoclonal antibodies (MoAbs) to regions of the human factor IX molecule. A-2 maps to 17 amino acids at the amino terminus of the heavy chain of IXa; 2D5, an inhibitor of clotting, is defined to 36 amino acids of the first EGF-like domain of human factor IX. A-4, A-5, C10D, and FXC008 all map to a region of the heavy chain containing amino acids 180 through 310, suggesting an immunodominant site. FXC008 has been reported to interfere with binding of factor IXa to factor VIII:Ca.
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Mapping of monoclonal antibodies to human factor IX.
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Autor/in / Beteiligte Person: | Frazier, D ; Smith, KJ ; Cheung, WF ; Ware, J ; Lin, SW ; Thompson, AR ; Reisner, H ; Bajaj, SP ; Stafford, DW |
Zeitschrift: | Blood, Jg. 74 (1989-08-15), Heft 3, S. 971 |
Veröffentlichung: | 2021- : [New York] : Elsevier ; <i>Original Publication</i>: New York, Grune & Stratton [etc.], 1989 |
Medientyp: | academicJournal |
ISSN: | 0006-4971 (print) |
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