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This study investigated the effect of Icariin (ICA) supplementation on diabetic retinopathy (DR) in a streptozotocin-induced diabetic rat model system. Fifty Sprague Dawley rats were randomly distributed into a control group and a streptozotocin-induced diabetes group. Diabetic rats were randomly divided into two groups; one group received ICA 5 mg/kg/day for 12 weeks by oral gavage; the other group received saline gavage as a placebo. Retinal morphological changes, endothelial markers (RECA), collagen IV (Col-IV), vascular endothelial growth factor (VEGF), and neuropathic changes (Thy-1 and Brn3a expression) of the retinal ganglion cells (RGCs) were investigated. The effects of ICA at various concentrations (0, 10(1), 10(2), 10(3) nmol/mL) on neurite growth were investigated also in retinal ganglion cells (RGC) cultured from both diabetic and normal animals. Numerous pathological changes (deceased expression of RECA, VEGF, Thy-1, and Brn3a as well as decreased Collagen IV and Müller cell content) were noted in the retinal vessels of diabetic rats; these changes were attenuated in diabetic animals that received ICA. ICA enhanced neurite growth in RGC from both normal rats and diabetic rats in a dose dependent fashion. ICA may be useful in the treatment of diabetic retinopathy. Further investigations are indicated.

Titel:	Icariin ameliorates streptozotocin-induced diabetic retinopathy in vitro and in vivo.
Autor/in / Beteiligte Person:	Xin, H ; Zhou, F ; Liu, T ; Li, GY ; Liu, J ; Gao, ZZ ; Bai, GY ; Lu, H ; Xin, ZC
Link:	Zum Volltext
Zeitschrift:	International journal of molecular sciences, Jg. 13 (2012), Heft 1, S. 866
Veröffentlichung:	Basel, Switzerland : MDPI, [2000-, 2012
Medientyp:	academicJournal
ISSN:	1422-0067 (electronic)
DOI:	10.3390/ijms13010866
Schlagwort:	Animals Collagen Type IV metabolism Diabetes Mellitus, Experimental chemically induced Diabetes Mellitus, Experimental pathology Flavonoids pharmacology Male Rats Rats, Sprague-Dawley Rec A Recombinases metabolism Retina metabolism Retina pathology Retinal Ganglion Cells cytology Retinal Ganglion Cells drug effects Retinal Ganglion Cells metabolism Retinal Vessels metabolism Streptozocin toxicity Thy-1 Antigens metabolism Transcription Factor Brn-3A metabolism Vascular Endothelial Growth Factor A metabolism Diabetes Mellitus, Experimental drug therapy Flavonoids therapeutic use
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Int J Mol Sci] 2012; Vol. 13 (1), pp. 866-878. <i>Date of Electronic Publication: </i>2012 Jan 16. MeSH Terms: Diabetes Mellitus, Experimental / drug therapy ; Flavonoids / therapeutic use ; Animals ; Collagen Type IV / metabolism ; Diabetes Mellitus, Experimental / chemically induced ; Diabetes Mellitus, Experimental / pathology ; Flavonoids / pharmacology ; Male ; Rats ; Rats, Sprague-Dawley ; Rec A Recombinases / metabolism ; Retina / metabolism ; Retina / pathology ; Retinal Ganglion Cells / cytology ; Retinal Ganglion Cells / drug effects ; Retinal Ganglion Cells / metabolism ; Retinal Vessels / metabolism ; Streptozocin / toxicity ; Thy-1 Antigens / metabolism ; Transcription Factor Brn-3A / metabolism ; Vascular Endothelial Growth Factor A / metabolism References: J Neurosci Res. 2008 Feb 15;86(3):702-11. (PMID: 17943991) ; Exp Eye Res. 2007 May;84(5):812-22. (PMID: 17331500) ; Endocrine. 2011 Jun;39(3):251-8. (PMID: 21086190) ; J Ethnopharmacol. 2011 Dec 8;138(3):731-6. (PMID: 22027446) ; Curr Diab Rep. 2011 Aug;11(4):244-52. (PMID: 21590515) ; Clin Exp Optom. 2010 Sep;93(5):309-23. (PMID: 20579078) ; Nature. 2001 Dec 13;414(6865):813-20. (PMID: 11742414) ; Asian J Androl. 2005 Dec;7(4):381-8. (PMID: 16281085) ; J Sex Med. 2006 Mar;3(2):242-50; discussion 250-2. (PMID: 16490017) ; Front Biosci (Landmark Ed). 2011 Jan 01;16:1733-45. (PMID: 21196259) ; Diabetes. 2006 May;55(5):1463-9. (PMID: 16644706) ; Diabetes Res Clin Pract. 2009 Dec;86 Suppl 1:S2-6. (PMID: 20115927) ; Diabetes Metab Res Rev. 2004 Mar-Apr;20(2):91-113. (PMID: 15037985) ; Exp Eye Res. 2011 Apr;92(4):260-7. (PMID: 21315070) ; N Engl J Med. 2004 Jan 1;350(1):48-58. (PMID: 14702427) ; J Biol Chem. 2006 Jul 28;281(30):21469-21479. (PMID: 16735511) ; Asian J Androl. 2003 Mar;5(1):15-8. (PMID: 12646997) ; Diabetes Care. 1992 Dec;15(12):1875-91. (PMID: 1464243) ; Eye (Lond). 2009 Jul;23(7):1496-508. (PMID: 19444297) ; J Cardiovasc Dis Res. 2011 Apr;2(2):96-103. (PMID: 21814413) ; Curr Opin Ophthalmol. 2005 Apr;16(2):84-8. (PMID: 15744137) ; Diabetes. 2006 Sep;55(9):2401-11. (PMID: 16936187) ; Graefes Arch Clin Exp Ophthalmol. 2007 May;245(5):627-36. (PMID: 17219109) ; Arch Ophthalmol. 2004 Apr;122(4):477-85. (PMID: 15078664) ; Mol Vis. 2010 Dec 28;16:2867-72. (PMID: 21203402) ; J Sex Med. 2011 Oct;8(10):2761-72. (PMID: 21967314) ; J Sex Med. 2010 Apr;7(4 Pt 1):1518-28. (PMID: 20141584) ; BMJ. 2006 Sep 2;333(7566):475-80. (PMID: 16946335) ; J Androl. 2007 Mar-Apr;28(2):306-12. (PMID: 17079742) ; Diabetes. 2010 Jun;59(6):1528-38. (PMID: 20332345) Contributed Indexing: Keywords: diabetes; diabetic retinopathy; icariin; retina; streptozotocin ; Note: Original DateCompleted: 20121002 Substance Nomenclature: 0 (Collagen Type IV) ; 0 (Flavonoids) ; 0 (Thy-1 Antigens) ; 0 (Transcription Factor Brn-3A) ; 0 (Vascular Endothelial Growth Factor A) ; 5W494URQ81 (Streptozocin) ; EC 2.7.7.- (Rec A Recombinases) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20120208 Date Completed: 20150226 Latest Revision: 20220922 Update Code: 20240513 PubMed Central ID: PMC3269725

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Icariin ameliorates streptozotocin-induced diabetic retinopathy in vitro and in vivo.