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Homologous recombination repairs DNA double-strand breaks by searching for, invading, and copying information from a homologous template, typically the homologous chromosome or sister chromatid. Tight wrapping of DNA around histone octamers, however, impedes access of repair proteins to DNA damage. To facilitate DNA repair, modifications of histones and energy-dependent remodeling of chromatin are required, but the precise mechanisms by which chromatin modification and remodeling enzymes contribute to homologous DNA repair are unknown. Here we have systematically assessed the role of budding yeast RSC (remodel structure of chromatin), an abundant, ATP-dependent chromatin-remodeling complex, in the cellular response to spontaneous and induced DNA damage. RSC physically interacts with the recombination protein Rad59 and functions in homologous recombination. Multiple recombination assays revealed that RSC is uniquely required for recombination between sister chromatids by virtue of its ability to recruit cohesin at DNA breaks and thereby promoting sister chromatid cohesion. This study provides molecular insights into how chromatin remodeling contributes to DNA repair and maintenance of chromatin fidelity in the face of DNA damage.

Titel:	RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks.
Autor/in / Beteiligte Person:	Oum, JH ; Seong, C ; Kwon, Y ; Ji, JH ; Sid, A ; Ramakrishnan, S ; Ira, G ; Malkova, A ; Sung, P ; Lee, SE ; Shim, EY
Link:	Zum Volltext
Zeitschrift:	Molecular and cellular biology, Jg. 31 (2011-10-01), Heft 19, S. 3924
Veröffentlichung:	2023- : [Philadelphia] : Taylor & Francis ; <i>Original Publication</i>: [Washington, D.C.] : American Society for Microbiology, [c1981-, 2011
Medientyp:	academicJournal
ISSN:	1098-5549 (electronic)
DOI:	10.1128/MCB.01269-10
Schlagwort:	Cell Cycle physiology Cell Cycle Proteins genetics Chromatin Assembly and Disassembly Chromosomal Proteins, Non-Histone genetics DNA-Binding Proteins genetics Rad51 Recombinase genetics Rad51 Recombinase metabolism Saccharomyces cerevisiae genetics Saccharomyces cerevisiae physiology Saccharomyces cerevisiae Proteins genetics Transcription Factors genetics Two-Hybrid System Techniques Cohesins Cell Cycle Proteins metabolism Chromatids metabolism Chromosomal Proteins, Non-Histone metabolism DNA Breaks, Double-Stranded DNA-Binding Proteins metabolism Homologous Recombination Recombinational DNA Repair Saccharomyces cerevisiae Proteins metabolism Transcription Factors metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Mol Cell Biol] 2011 Oct; Vol. 31 (19), pp. 3924-37. <i>Date of Electronic Publication: </i>2011 Aug 01. MeSH Terms: DNA Breaks, Double-Stranded* ; Homologous Recombination* ; Recombinational DNA Repair* ; Cell Cycle Proteins / metabolism ; Chromatids / metabolism ; Chromosomal Proteins, Non-Histone / metabolism ; DNA-Binding Proteins / metabolism ; Saccharomyces cerevisiae Proteins / metabolism ; Transcription Factors / metabolism ; Cell Cycle / physiology ; Cell Cycle Proteins / genetics ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone / genetics ; DNA-Binding Proteins / genetics ; Rad51 Recombinase / genetics ; Rad51 Recombinase / metabolism ; Saccharomyces cerevisiae / genetics ; Saccharomyces cerevisiae / physiology ; Saccharomyces cerevisiae Proteins / genetics ; Transcription Factors / genetics ; Two-Hybrid System Techniques ; Cohesins Comments: Comment in: Mol Cell Biol. 2011 Oct;31(19):3921-3. (PMID: 21844225) References: Mol Cell. 2008 May 9;30(3):325-35. (PMID: 18471978) ; J Biol Chem. 2007 Sep 21;282(38):27693-701. (PMID: 17652077) ; J Biol Chem. 1996 Nov 8;271(45):27983-6. (PMID: 8910403) ; J Biol Chem. 1997 Nov 7;272(45):28194-7. (PMID: 9353267) ; Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9315-20. (PMID: 15199178) ; Genes Dev. 2005 Jul 15;19(14):1656-61. (PMID: 16024655) ; Curr Opin Genet Dev. 2007 Apr;17(2):126-31. (PMID: 17320375) ; DNA Repair (Amst). 2010 Jan 2;9(1):23-32. (PMID: 19892607) ; Mol Cell Biol. 2005 Dec;25(24):10782-90. (PMID: 16314503) ; Annu Rev Biochem. 2008;77:229-57. (PMID: 18275380) ; Cell Cycle. 2005 Aug;4(8):1011-4. (PMID: 16082209) ; Mol Cell. 2004 Dec 22;16(6):1003-15. (PMID: 15610742) ; Nat Genet. 2005 Sep;37(9):986-90. (PMID: 16086015) ; J Biol Chem. 2008 May 2;283(18):12166-74. (PMID: 18310075) ; Nucleic Acids Res. 1998 Aug 15;26(16):3739-45. (PMID: 9685490) ; Microbiol Mol Biol Rev. 2002 Dec;66(4):630-70, table of contents. (PMID: 12456786) ; Cell Cycle. 2008 Apr 1;7(7):859-64. (PMID: 18414031) ; Gene. 2007 Jun 15;395(1-2):72-85. (PMID: 17400406) ; Methods Enzymol. 2006;409:101-17. (PMID: 16793397) ; Genetics. 2008 Aug;179(4):1845-60. (PMID: 18689895) ; Mol Cell. 2008 Jul 11;31(1):47-56. (PMID: 18614046) ; J Mol Histol. 2006 Sep;37(5-7):261-9. (PMID: 17120107) ; Microbiol Mol Biol Rev. 1999 Jun;63(2):349-404. (PMID: 10357855) ; Nat Struct Mol Biol. 2008 Dec;15(12):1272-7. (PMID: 19029894) ; Curr Biol. 2004 Dec 14;14(23):2096-106. (PMID: 15589151) ; Genes Dev. 1998 Jul 15;12(14):2208-21. (PMID: 9679065) ; J Biol Chem. 2003 Mar 14;278(11):9212-8. (PMID: 12514177) ; DNA Repair (Amst). 2003 Oct 7;2(10):1127-34. (PMID: 13679150) ; Mol Cell. 2004 Mar 12;13(5):739-50. (PMID: 15023343) ; J Biol Chem. 1999 Nov 26;274(48):33839-42. (PMID: 10567339) ; J Genet. 1949 Dec;49(3):264-85. (PMID: 24536673) ; Science. 2007 Jul 13;317(5835):245-8. (PMID: 17626885) ; Nature. 1998 Jan 22;391(6665):404-7. (PMID: 9450759) ; Nucleic Acids Res. 2003 May 15;31(10):2576-85. (PMID: 12736307) ; Cell. 1998 Aug 7;94(3):399-409. (PMID: 9708741) ; Genetics. 2001 Oct;159(2):515-25. (PMID: 11606529) ; Mol Cell Biol. 2005 Jul;25(14):5880-92. (PMID: 15988005) ; J Biol Chem. 2002 Nov 22;277(47):45149-53. (PMID: 12228239) ; Genes Dev. 1996 Aug 15;10(16):2025-37. (PMID: 8769646) ; Nature. 2007 Jun 21;447(7147):951-8. (PMID: 17581578) ; Mol Cell Biol. 2006 Dec;26(24):9424-9. (PMID: 17030630) ; Cell. 2009 Oct 2;139(1):87-99. (PMID: 19804755) ; Curr Biol. 2007 Aug 21;17(16):1432-7. (PMID: 17689960) ; Genetics. 1999 Feb;151(2):447-58. (PMID: 9927442) ; Mol Cell Biol. 2007 Mar;27(5):1602-13. (PMID: 17178837) ; Mol Cell Biol. 2000 Jul;20(14):5300-9. (PMID: 10866686) ; Mutat Res. 2007 May 1;618(1-2):65-80. (PMID: 17291544) ; Mol Cell Biol. 2005 May;25(10):3934-44. (PMID: 15870268) ; J Biol Chem. 2006 Jun 2;281(22):15441-9. (PMID: 16565518) ; Science. 2007 Jul 13;317(5835):242-5. (PMID: 17626884) ; Annu Rev Genet. 2006;40:209-35. (PMID: 16805667) ; Mol Cell Biol. 1998 Jul;18(7):4400-6. (PMID: 9632824) ; Mol Cell Biol. 2004 Feb;24(3):1232-44. (PMID: 14729968) ; Nat Struct Mol Biol. 2007 Jul;14(7):639-46. (PMID: 17589524) ; Yeast. 2001 Oct;18(14):1317-30. (PMID: 11571756) ; Mol Genet Genomics. 2003 Jun;269(3):321-30. (PMID: 12684875) ; Cell. 2008 Sep 19;134(6):981-94. (PMID: 18805091) ; DNA Repair (Amst). 2007 Jan 4;6(1):27-37. (PMID: 16987715) ; Mol Cell. 2004 Dec 22;16(6):991-1002. (PMID: 15610741) ; Cell. 1996 Dec 27;87(7):1249-60. (PMID: 8980231) ; Nature. 1998 Jan 22;391(6665):407-10. (PMID: 9450760) ; Nature. 2008 Jul 24;454(7203):543-6. (PMID: 18650924) ; Cell. 1999 Feb 5;96(3):389-92. (PMID: 10025404) ; Proc Natl Acad Sci U S A. 1987 Sep;84(17):6215-9. (PMID: 3306671) ; Bioessays. 2009 Mar;31(3):315-21. (PMID: 19260026) ; Mol Cell Biol. 2002 Dec;22(23):8165-74. (PMID: 12417720) ; Mol Cell Biol. 1992 Feb;12(2):563-75. (PMID: 1732731) ; Nat Rev Mol Cell Biol. 2005 Oct;6(10):757-65. (PMID: 16167054) ; Annu Rev Biochem. 2006;75:111-35. (PMID: 16756487) ; Mol Cell. 1999 Nov;4(5):715-23. (PMID: 10619019) ; Nature. 2008 Oct 9;455(7214):770-4. (PMID: 18806779) ; Genetics. 2006 Feb;172(2):795-809. (PMID: 16204215) ; Methods Enzymol. 2004;377:322-43. (PMID: 14979035) ; Biochim Biophys Acta. 2002 Oct 2;1603(1):19-29. (PMID: 12242108) ; Curr Genet. 1999 Aug;36(1-2):13-20. (PMID: 10447590) Grant Information: 3R01 GM071011 United States GM NIGMS NIH HHS; R01 GM057814 United States GM NIGMS NIH HHS; R01 GM080600 United States GM NIGMS NIH HHS; GM080600 United States GM NIGMS NIH HHS; GM084242-01 United States GM NIGMS NIH HHS; R01 GM084242-04 United States GM NIGMS NIH HHS; R01 GM071011 United States GM NIGMS NIH HHS; R01 GM084242 United States GM NIGMS NIH HHS; R01GM57814 United States GM NIGMS NIH HHS; 3R01GM080600 United States GM NIGMS NIH HHS; GM071011 United States GM NIGMS NIH HHS Substance Nomenclature: 0 (Cell Cycle Proteins) ; 0 (Chromosomal Proteins, Non-Histone) ; 0 (DNA-Binding Proteins) ; 0 (NPL6 protein, S cerevisiae) ; 0 (RAD59 protein, S cerevisiae) ; 0 (RSC complex, S cerevisiae) ; 0 (Saccharomyces cerevisiae Proteins) ; 0 (Transcription Factors) ; EC 2.7.7.- (Rad51 Recombinase) Entry Date(s): Date Created: 20110803 Date Completed: 20111212 Latest Revision: 20231213 Update Code: 20231215 PubMed Central ID: PMC3187356

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RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks.