Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats.

Li, F ; Gong, QH ; et al.

In: Pharmacology, biochemistry, and behavior, Jg. 96 (2010-09-01), Heft 3, S. 301

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The effects of icariin (ICA), a major constituent of flavonoids from the Chinese medical herb Epimedium brevicornum Maxim, on spatial memory performances and expressions of hippocampus brain-derived neurotrophic factor (BDNF) and tyrosine kinase TrkB (tropomyosin receptor kinase B) were investigated in d-galactose (d-gal)-treated rats. Subcutaneous injection of d-gal (500mg/kg/d) for four months caused memory loss as detected by the Morris water maze, morphologic abnormalities of neurons in hippocampus region and the reduced expression of BDNF and TrkB were observed. ICA (60mg/kg/d) given orally 1h after subcutaneous injection of d-gal daily for 4months markedly attenuated d-gal-induced rats behavioral dysfunction and neurodegeneration, as evidenced by shortened escape latency and searching distance and rescued morphologic abnormalities, and also elevated the mRNA levels and the protein expressions of BDNF and TrkB in hippocampus, as evidenced by quantitative real-time RT-PCR and Western blotting analysis. But ICA had no significant influence on normal rats which were not injected d-gal. These results clearly demonstrated that d-gal produced learning and memory deficits after chronic administration, and ICA can protect neuron from d-gal insults and improve the memory loss.

Titel:	Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats.
Autor/in / Beteiligte Person:	Li, F ; Gong, QH ; Wu, Q ; Lu, YF ; Shi, JS
Link:	Zum Volltext
Zeitschrift:	Pharmacology, biochemistry, and behavior, Jg. 96 (2010-09-01), Heft 3, S. 301
Veröffentlichung:	Tarrytown, NY : Elsevier ; <i>Original Publication</i>: Phoenix, N. Y. Ankho International, ltd., 2010
Medientyp:	academicJournal
ISSN:	1873-5177 (electronic)
DOI:	10.1016/j.pbb.2010.05.021
Schlagwort:	Animals Blotting, Western Brain Chemistry drug effects Brain-Derived Neurotrophic Factor biosynthesis Flavonoids isolation & purification Hippocampus metabolism Hippocampus pathology Learning Disabilities chemically induced Learning Disabilities psychology Male Maze Learning drug effects Memory Disorders chemically induced Memory Disorders psychology Nerve Tissue Proteins metabolism RNA, Messenger biosynthesis RNA, Messenger genetics Rats Rats, Sprague-Dawley Receptor, trkB biosynthesis Reverse Transcriptase Polymerase Chain Reaction Epimedium chemistry Flavonoids pharmacology Galactose antagonists & inhibitors Galactose toxicity Learning Disabilities drug therapy Memory Disorders drug therapy Neuroprotective Agents
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Pharmacol Biochem Behav] 2010 Sep; Vol. 96 (3), pp. 301-5. <i>Date of Electronic Publication: </i>2010 Jun 01. MeSH Terms: Neuroprotective Agents* ; Epimedium / chemistry ; Flavonoids / pharmacology ; Galactose / antagonists & inhibitors ; Galactose / toxicity ; Learning Disabilities / drug therapy ; Memory Disorders / drug therapy ; Animals ; Blotting, Western ; Brain Chemistry / drug effects ; Brain-Derived Neurotrophic Factor / biosynthesis ; Flavonoids / isolation & purification ; Hippocampus / metabolism ; Hippocampus / pathology ; Learning Disabilities / chemically induced ; Learning Disabilities / psychology ; Male ; Maze Learning / drug effects ; Memory Disorders / chemically induced ; Memory Disorders / psychology ; Nerve Tissue Proteins / metabolism ; RNA, Messenger / biosynthesis ; RNA, Messenger / genetics ; Rats ; Rats, Sprague-Dawley ; Receptor, trkB / biosynthesis ; Reverse Transcriptase Polymerase Chain Reaction Substance Nomenclature: 0 (Brain-Derived Neurotrophic Factor) ; 0 (Flavonoids) ; 0 (Nerve Tissue Proteins) ; 0 (Neuroprotective Agents) ; 0 (RNA, Messenger) ; EC 2.7.10.1 (Receptor, trkB) ; VNM47R2QSQ (icariin) ; X2RN3Q8DNE (Galactose) Entry Date(s): Date Created: 20100623 Date Completed: 20101028 Latest Revision: 20220408 Update Code: 20231215

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