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Microglia in the central nervous system (CNS) play an important role in the initiation of neuroinflammatory response. Icariin, a compound from Epimedium brevicornum Maxim, has been reported to have anti-inflammatory effect on the macrophage cell line RAW264.7. However, it is currently unknown what anti-inflammatory role icariin may play in the CNS. Here, we reported the discovery that icariin significantly inhibited the release of nitric oxide (NO), prostaglandin E (PGE)-2, reactive oxygen species (ROS) and mRNA expression of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in lipopolysaccharide (LPS)-activated microglia. Icariin also inhibited the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in a dose-dependent manner. Further mechanism studies revealed that icariin blocked TAK1/IKK/NF-kappaB and JNK/p38 MAPK pathways. It was also found that icariin reduced the degeneration of cortical neurons induced by LPS-activated microglia in neuron-microglia co-culture system. Taken together these findings provide mechanistic insights into the suppressive effect of icariin on LPS-induced neuroinflammatory response in microglia, and emphasize the neuroprotective effect and therapeutic potential of icariin in neuroinflammatory diseases.

Titel:	Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-kappaB and JNK/p38 MAPK pathways.
Autor/in / Beteiligte Person:	Zeng, KW ; Fu, H ; Liu, GX ; Wang, XM
Link:	Zum Volltext
Zeitschrift:	International immunopharmacology, Jg. 10 (2010-06-01), Heft 6, S. 668
Veröffentlichung:	Amsterdam ; New York : Elsevier Science, c2001-, 2010
Medientyp:	academicJournal
ISSN:	1878-1705 (electronic)
DOI:	10.1016/j.intimp.2010.03.010
Schlagwort:	Animals Cell Death drug effects Cerebral Cortex drug effects Cerebral Cortex pathology Cyclooxygenase 2 analysis Cytokines analysis Cytokines metabolism Dinoprostone analysis Dinoprostone metabolism Encephalitis drug therapy I-kappa B Kinase metabolism JNK Mitogen-Activated Protein Kinases metabolism Lipopolysaccharides MAP Kinase Kinase Kinases metabolism Microglia enzymology NF-kappa B metabolism Neurons enzymology Nitric Oxide analysis Nitric Oxide metabolism Nitric Oxide Synthase Type II analysis Phosphorylation Rats Rats, Sprague-Dawley Reactive Oxygen Species analysis Reactive Oxygen Species metabolism p38 Mitogen-Activated Protein Kinases metabolism Flavonoids pharmacology I-kappa B Kinase antagonists & inhibitors JNK Mitogen-Activated Protein Kinases antagonists & inhibitors MAP Kinase Kinase Kinases antagonists & inhibitors Microglia drug effects NF-kappa B antagonists & inhibitors Neurons drug effects Neuroprotective Agents pharmacology p38 Mitogen-Activated Protein Kinases antagonists & inhibitors
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Int Immunopharmacol] 2010 Jun; Vol. 10 (6), pp. 668-78. <i>Date of Electronic Publication: </i>2010 Mar 25. MeSH Terms: Flavonoids / pharmacology ; I-kappa B Kinase / antagonists & inhibitors ; JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors ; MAP Kinase Kinase Kinases / antagonists & inhibitors ; Microglia / drug effects ; NF-kappa B / antagonists & inhibitors ; Neurons / drug effects ; Neuroprotective Agents / pharmacology ; p38 Mitogen-Activated Protein Kinases / *antagonists & inhibitors ; Animals ; Cell Death / drug effects ; Cerebral Cortex / drug effects ; Cerebral Cortex / pathology ; Cyclooxygenase 2 / analysis ; Cytokines / analysis ; Cytokines / metabolism ; Dinoprostone / analysis ; Dinoprostone / metabolism ; Encephalitis / drug therapy ; I-kappa B Kinase / metabolism ; JNK Mitogen-Activated Protein Kinases / metabolism ; Lipopolysaccharides ; MAP Kinase Kinase Kinases / metabolism ; Microglia / enzymology ; NF-kappa B / metabolism ; Neurons / enzymology ; Nitric Oxide / analysis ; Nitric Oxide / metabolism ; Nitric Oxide Synthase Type II / analysis ; Phosphorylation ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species / analysis ; Reactive Oxygen Species / metabolism ; p38 Mitogen-Activated Protein Kinases / metabolism Substance Nomenclature: 0 (Cytokines) ; 0 (Flavonoids) ; 0 (Lipopolysaccharides) ; 0 (NF-kappa B) ; 0 (Neuroprotective Agents) ; 0 (Reactive Oxygen Species) ; 31C4KY9ESH (Nitric Oxide) ; EC 1.14.13.39 (Nitric Oxide Synthase Type II) ; EC 1.14.99.1 (Cyclooxygenase 2) ; EC 2.7.11.10 (I-kappa B Kinase) ; EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases) ; EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases) ; EC 2.7.11.25 (MAP Kinase Kinase Kinases) ; EC 2.7.11.25 (MAP kinase kinase kinase 7) ; K7Q1JQR04M (Dinoprostone) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20100330 Date Completed: 20100903 Latest Revision: 20220408 Update Code: 20231215

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Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-kappaB and JNK/p38 MAPK pathways.