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Objective: To research the protective effects and mechanisms of Radix Astragali injection on the intestinal mucosa of rats with obstructive jaundice (OJ).

Methods: The rats were randomly divided into sham-operated, model control and Radix Astragali treated group. We observed the pathological changes of intestinal mucosa, expression levels of Bax and NF-kappaB proteins, and apoptosis indexes in intestinal mucosa as well as serum NO, MDA and SOD contents, respectively, on 7d, 14d, 21d and 28d after operation.

Results: The pathological severity score (on 7d and 14d), apoptotic indexes (on 14d) of the intestinal mucosa and serum MDA content (on 14d) of treated group were significantly lower than those in the model control group (P < .05). The serum SOD contents (on all time points) of treated group were significantly higher than those in the model control group (P < .05). The sham-operated group (on 21d) of the product of staining intensity and positive rate of Bax protein was significantly lower than model control group (P < .05).

Conclusion: Radix Astragali injection could protect the intestinal mucosa of OJ rats by increasing the content of SOD, reducing the content of MDA, inhibiting the apoptosis and relieving the pathological changes of intestinal mucosa.

Titel:	Protective effect and mechanisms of radix astragali injection on the intestinal mucosa of rats with obstructive jaundice.
Autor/in / Beteiligte Person:	Xiping, Z ; Ke, W ; Yaping, Y ; Hongchan, Z ; Qihui, C
Link:	Zum Volltext
Zeitschrift:	Mediators of inflammation, Jg. 2010 (2010), S. 757191
Veröffentlichung:	2005- : Sylvania, OH : Hindawi Pub. Corp. ; <i>Original Publication</i>: Oxford, UK : Rapid Communications of Oxford Ltd., c1992-, 2010
Medientyp:	academicJournal
ISSN:	1466-1861 (electronic)
DOI:	10.1155/2010/757191
Schlagwort:	Animals Apoptosis drug effects Intestinal Mucosa metabolism Intestinal Mucosa pathology Jaundice, Obstructive metabolism Jaundice, Obstructive pathology Male Malondialdehyde blood NF-kappa B metabolism Nitric Oxide blood Random Allocation Rats Rats, Sprague-Dawley Superoxide Dismutase blood Survival Rate Astragalus Plant chemistry Intestinal Mucosa drug effects Jaundice, Obstructive drug therapy Plant Extracts pharmacology Plant Extracts therapeutic use
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Mediators Inflamm] 2010; Vol. 2010, pp. 757191. <i>Date of Electronic Publication: </i>2010 Mar 14. MeSH Terms: Plant Extracts* / pharmacology ; Plant Extracts* / therapeutic use ; Astragalus Plant / chemistry ; Intestinal Mucosa / drug effects ; Jaundice, Obstructive / *drug therapy ; Animals ; Apoptosis / drug effects ; Intestinal Mucosa / metabolism ; Intestinal Mucosa / pathology ; Jaundice, Obstructive / metabolism ; Jaundice, Obstructive / pathology ; Male ; Malondialdehyde / blood ; NF-kappa B / metabolism ; Nitric Oxide / blood ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase / blood ; Survival Rate References: IUBMB Life. 2008 Jul;60(7):473-80. (PMID: 18481805) ; Dig Dis Sci. 2001 Mar;46(3):545-9. (PMID: 11318530) ; Stroke. 1998 Mar;29(3):677-82. (PMID: 9506612) ; Gut. 1998 Feb;42(2):293-9. (PMID: 9536958) ; Shock. 2002 Jul;18(1):86-92. (PMID: 12095141) ; Nan Fang Yi Ke Da Xue Xue Bao. 2007 Jul;27(7):987-90. (PMID: 17666333) ; J Neurochem. 2000 Apr;74(4):1613-20. (PMID: 10737619) ; Scand J Gastroenterol. 1998 Apr;33(4):415-22. (PMID: 9605264) ; Shock. 2000 Mar;13(3):209-16. (PMID: 10718378) ; World J Gastroenterol. 2007 Dec 28;13(48):6458-64. (PMID: 18161914) ; Ann Surg. 1990 Aug;212(2):221-7. (PMID: 2375652) ; Exp Biol Med (Maywood). 2001 Jul;226(7):692-700. (PMID: 11444106) ; Surgery. 2002 May;131(5):556-63. (PMID: 12019410) ; J Gastroenterol Hepatol. 2008 Feb;23(2):328-35. (PMID: 17868332) ; Transplantation. 2000 Feb 27;69(4):598-604. (PMID: 10708117) ; Am J Physiol Gastrointest Liver Physiol. 2004 Jan;286(1):G126-36. (PMID: 12946943) ; World J Gastroenterol. 2009 Jun 21;15(23):2862-9. (PMID: 19533807) ; Pancreas. 1998 Apr;16(3):312-5. (PMID: 9548672) ; Free Radic Res. 2008 Feb;42(2):180-8. (PMID: 18297611) ; Am J Physiol. 1997 Aug;273(2 Pt 1):G253-7. (PMID: 9277401) ; Pancreas. 2008 Oct;37(3):e74-82. (PMID: 18815542) ; Am J Physiol. 1997 Dec;273(6):G1174-88. (PMID: 9435542) ; J Invest Surg. 2006 Sep-Oct;19(5):283-9. (PMID: 16966206) ; Ann Clin Lab Sci. 2001 Oct;31(4):383-90. (PMID: 11688850) ; Apoptosis. 2008 Jul;13(7):950-8. (PMID: 18500555) ; Surg Clin North Am. 2006 Dec;86(6):1495-502. (PMID: 17116459) ; Br J Surg. 1996 Oct;83(10):1345-9. (PMID: 8944448) ; J Surg Res. 2003 Oct;114(2):110-7. (PMID: 14559434) ; Am J Surg. 1996 Jan;171(1):202-6. (PMID: 8554142) ; J Cell Biol. 1997 Dec 1;139(5):1281-92. (PMID: 9382873) ; Apoptosis. 2005 Aug;10(4):809-20. (PMID: 16133871) ; Dig Dis Sci. 2002 Apr;47(4):929-34. (PMID: 11991630) ; World J Surg. 1996 May;20(4):411-7. (PMID: 8662128) ; Am J Physiol. 1999 Mar;276(3):G677-86. (PMID: 10070044) ; Genes Dev. 1999 Aug 1;13(15):1899-911. (PMID: 10444588) ; Histochem Cell Biol. 2005 Mar;123(3):249-61. (PMID: 15765213) Substance Nomenclature: 0 (NF-kappa B) ; 0 (Plant Extracts) ; 31C4KY9ESH (Nitric Oxide) ; 4Y8F71G49Q (Malondialdehyde) ; EC 1.15.1.1 (Superoxide Dismutase) Entry Date(s): Date Created: 20100320 Date Completed: 20100607 Latest Revision: 20211020 Update Code: 20240513 PubMed Central ID: PMC2838217

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Protective effect and mechanisms of radix astragali injection on the intestinal mucosa of rats with obstructive jaundice.