Icariin inhibits the increased inward calcium currents induced by amyloid-beta(25-35) peptide in CA1 pyramidal neurons of neonatal rat hippocampal slice.

Li, L ; Tsai, HJ ; et al.

In: The American journal of Chinese medicine, Jg. 38 (2010), Heft 1, S. 113

academicJournal

Overload of intracellular calcium caused by amyloid-beta peptide has been implicated in the pathogenesis of neuronal damage in Alzheimer's disease. Voltage-gated calcium channels (VGCCs) provide one of the major sources of Ca(2+) entry into cells. Here, we investigated whether icariin had effect on the changes of calcium currents induced by Abeta(25-35) in hippocampal pyramidal neurons. Using whole-cell patch-clamp, we showed that Abeta(25-35) enhanced the inward Ba(2+) and Ca(2+) currents. The currents were partially inhibited by Ni(2+) and completely suppressed by Cd(2+), indicating that Abeta(25-35) disrupts intracellular calcium homeostasis via the modulation of both L- and T-type channels. Furthermore, icariin nearly complete suppressed the abnormal inward calcium currents induced by Abeta(25-35) in a dose-dependant manner. Our findings suggest that the potential neuroprotective effect of icariin on Abeta(25-35)-induced neurotoxicity via the balance intracelluar calcium homeostasis.

Titel:	Icariin inhibits the increased inward calcium currents induced by amyloid-beta(25-35) peptide in CA1 pyramidal neurons of neonatal rat hippocampal slice.
Autor/in / Beteiligte Person:	Li, L ; Tsai, HJ ; Wang, XM
Zeitschrift:	The American journal of Chinese medicine, Jg. 38 (2010), Heft 1, S. 113
Veröffentlichung:	<2003->: Singapore ; River Edge, NJ : World Scientific Pub. ; <i>Original Publication</i>: [Garden City, N.Y.] : Institute for Advanced Research in Asian Science and Medicine, 2010
Medientyp:	academicJournal
ISSN:	1793-6853 (electronic)
DOI:	10.1142/S0192415X10007701
Schlagwort:	Alzheimer Disease prevention & control Animals Animals, Newborn Barium metabolism Cadmium pharmacology Calcium Channels, L-Type drug effects Calcium Channels, T-Type drug effects Dose-Response Relationship, Drug Epimedium chemistry Hippocampus metabolism Homeostasis Ion Channels drug effects Neurons Nickel pharmacology Patch-Clamp Techniques Rats Rats, Sprague-Dawley Amyloid beta-Peptides metabolism Calcium metabolism Calcium Channels drug effects Flavonoids pharmacology Hippocampus drug effects Neuroprotective Agents pharmacology Plant Extracts pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Am J Chin Med] 2010; Vol. 38 (1), pp. 113-25. MeSH Terms: Amyloid beta-Peptides / metabolism ; Calcium / metabolism ; Calcium Channels / drug effects ; Flavonoids / pharmacology ; Hippocampus / drug effects ; Neuroprotective Agents / pharmacology ; Plant Extracts / *pharmacology ; Alzheimer Disease / prevention & control ; Animals ; Animals, Newborn ; Barium / metabolism ; Cadmium / pharmacology ; Calcium Channels, L-Type / drug effects ; Calcium Channels, T-Type / drug effects ; Dose-Response Relationship, Drug ; Epimedium / chemistry ; Hippocampus / metabolism ; Homeostasis ; Ion Channels / drug effects ; Neurons ; Nickel / pharmacology ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley Substance Nomenclature: 0 (Amyloid beta-Peptides) ; 0 (Calcium Channels) ; 0 (Calcium Channels, L-Type) ; 0 (Calcium Channels, T-Type) ; 0 (Flavonoids) ; 0 (Ion Channels) ; 0 (Neuroprotective Agents) ; 0 (Plant Extracts) ; 00BH33GNGH (Cadmium) ; 24GP945V5T (Barium) ; 7OV03QG267 (Nickel) ; SY7Q814VUP (Calcium) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20100204 Date Completed: 20100422 Latest Revision: 20161125 Update Code: 20231215

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.