Utility of a point-of-care malaria rapid diagnostic test for excluding malaria as the cause of fever among HIV-positive adults in rural Rakai, Uganda.
In: The American journal of tropical medicine and hygiene, Jg. 82 (2010), Heft 1, S. 145
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academicJournal
Zugriff:
We compared results of a malaria rapid diagnostic test (Binax Now Malaria, Binax-M, Inverness Medical Innovations, Inc., Waltham, MA) performed at rural mobile clinics in Uganda by clinicians evaluating febrile adult HIV patients to thick smear evaluated at a central laboratory by trained microscopists. Two hundred forty-six samples were analyzed, including 14 (5.7%) which were thick-smear positive for falciparum malaria. Sensitivity of Binax-M compared with thick smear was 85.7% (95% CI: 57.2-98.2), specificity 97.8% (95% CI: 94.9-99.3), positive and negative predictive values were 70.6% (95% CI: 44.0-89.7) and 99.1% (95% CI: 96.8-99.9), respectively. The rapid diagnostic test accurately ruled malaria "in or out" at the point-of-care, facilitating appropriate clinical management and averting unnecessary anti-malarial therapy.
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Utility of a point-of-care malaria rapid diagnostic test for excluding malaria as the cause of fever among HIV-positive adults in rural Rakai, Uganda.
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Autor/in / Beteiligte Person: | Mills, LA ; Kagaayi, J ; Nakigozi, G ; Galiwango, RM ; Ouma, J ; Shott, JP ; Ssempijja, V ; Gray, RH ; Wawer, MJ ; Serwadda, D ; Quinn, TC ; Reynolds, SJ |
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Zeitschrift: | The American journal of tropical medicine and hygiene, Jg. 82 (2010), Heft 1, S. 145 |
Veröffentlichung: | Northbrook, IL : American Society of Tropical Medicine and Hygiene ; <i>Original Publication</i>: Baltimore., 2010 |
Medientyp: | academicJournal |
ISSN: | 1476-1645 (electronic) |
DOI: | 10.4269/ajtmh.2010.09-0408 |
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