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beta-Amyloid peptide (Abeta) is one of the main protein components of senile plaques contributing to Alzheimer's disease and it can induce neuronal apoptosis. In this study, it was found that icariin, a flavonoid extracted from Chinese Herba-Epimedii, inhibited Abeta42-induced neurotoxicity in a dose-dependent manner. The peak dose of icariin was 160 microg/ml. In addition, mRNA and protein expressions of cocaine and amphetamine-regulated transcript (CART) were increased in Abeta42-treated neurons in the presence of 80 microg/ml icariin. Moreover, CART-RNA interference was able to reverse neuroprotection of icariin on Abeta42. Furthermore, the expression of CART can be suppressed by extracellular signal-regulated kinase inhibitor instead of p38/JNK inhibitors, suggesting that icariin may be developed into therapeutic agents for Alzheimer's disease and other neurodegenerative diseases.

Titel:	Icariin inhibits neurotoxicity of beta-amyloid by upregulating cocaine-regulated and amphetamine-regulated transcripts.
Autor/in / Beteiligte Person:	Sha, D ; Li, L ; Ye, L ; Liu, R ; Xu, Y
Link:	Zum Volltext
Zeitschrift:	Neuroreport, Jg. 20 (2009-11-25), Heft 17, S. 1564-7
Veröffentlichung:	London, England : Lippincott Williams & Wilkins ; <i>Original Publication</i>: Oxford, UK : Rapid Communications of Oxford Ltd., [1990-, 2009
Medientyp:	academicJournal
ISSN:	1473-558X (electronic)
DOI:	10.1097/WNR.0b013e328332d345
Schlagwort:	Alzheimer Disease metabolism Alzheimer Disease physiopathology Amyloid beta-Peptides toxicity Animals Cells, Cultured Cerebral Cortex metabolism Cerebral Cortex pathology Dose-Response Relationship, Drug Drugs, Chinese Herbal pharmacology Drugs, Chinese Herbal therapeutic use Enzyme Inhibitors pharmacology Extracellular Signal-Regulated MAP Kinases antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases metabolism Flavonoids therapeutic use Mice Nerve Tissue Proteins genetics Nerve Tissue Proteins metabolism Neurons metabolism Neurons pathology Neuroprotective Agents pharmacology Neuroprotective Agents therapeutic use Peptide Fragments antagonists & inhibitors Peptide Fragments toxicity RNA, Messenger drug effects RNA, Messenger metabolism Up-Regulation drug effects Up-Regulation physiology Alzheimer Disease drug therapy Amyloid beta-Peptides antagonists & inhibitors Cerebral Cortex drug effects Flavonoids pharmacology Nerve Tissue Proteins agonists Neurons drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Neuroreport] 2009 Nov 25; Vol. 20 (17), pp. 1564-7. MeSH Terms: Alzheimer Disease / drug therapy ; Amyloid beta-Peptides / antagonists & inhibitors ; Cerebral Cortex / drug effects ; Flavonoids / pharmacology ; Nerve Tissue Proteins / agonists ; Neurons / drug effects ; Alzheimer Disease / metabolism ; Alzheimer Disease / physiopathology ; Amyloid beta-Peptides / toxicity ; Animals ; Cells, Cultured ; Cerebral Cortex / metabolism ; Cerebral Cortex / pathology ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal / pharmacology ; Drugs, Chinese Herbal / therapeutic use ; Enzyme Inhibitors / pharmacology ; Extracellular Signal-Regulated MAP Kinases / antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases / metabolism ; Flavonoids / therapeutic use ; Mice ; Nerve Tissue Proteins / genetics ; Nerve Tissue Proteins / metabolism ; Neurons / metabolism ; Neurons / pathology ; Neuroprotective Agents / pharmacology ; Neuroprotective Agents / therapeutic use ; Peptide Fragments / antagonists & inhibitors ; Peptide Fragments / toxicity ; RNA, Messenger / drug effects ; RNA, Messenger / metabolism ; Up-Regulation / drug effects ; Up-Regulation / physiology Substance Nomenclature: 0 (Amyloid beta-Peptides) ; 0 (Drugs, Chinese Herbal) ; 0 (Enzyme Inhibitors) ; 0 (Flavonoids) ; 0 (Nerve Tissue Proteins) ; 0 (Neuroprotective Agents) ; 0 (Peptide Fragments) ; 0 (RNA, Messenger) ; 0 (amyloid beta-protein (1-42)) ; 0 (cocaine- and amphetamine-regulated transcript protein) ; EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20091028 Date Completed: 20100202 Latest Revision: 20161125 Update Code: 20231215

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Icariin inhibits neurotoxicity of beta-amyloid by upregulating cocaine-regulated and amphetamine-regulated transcripts.