Complex mosaic composition of near full-length genomes of two NED (NIH-ENVA-DOD) subtype panel HIV type 1 strains, BCF-Dioum and BCF-Kita, originating from the Democratic Republic of Congo (DRC).

Huang, DD ; Foley, BT ; et al.

In: AIDS research and human retroviruses, Jg. 25 (2009-10-01), Heft 10, S. 1039

academicJournal

Sequence characterization of the near full-length genomes of HIV-1 isolates BCF-Dioum and BCF-Kita, originating from the Democratic Republic of Congo (DRC), was continued. These NED panel isolates, contributed by F. Brun-Vezinet (ENVA-France), were first identified as subtypes G and H, respectively. Our earlier analyses of portions of their pol genes showed that both were likely to be intersubtype recombinants of different composition. This study analyzed the remainder of each genome, confirming them to be complex recombinants. The BCF-Dioum genome resembles CRF06_cpx strains found in West Africa, composed of subtypes A/G/J/K. The BCF-Kita genome is a unique complex recombinant A-F-G-H-K-U strain. These data support previous observations of the complexity of strains originating from the DRC. BCF-Dioum may be a suitable strain for standards and reagents since it matches a defined circulating recombinant form. Studies and reagents made from BCF-Kita should take into account its complex genome.

Titel:	Complex mosaic composition of near full-length genomes of two NED (NIH-ENVA-DOD) subtype panel HIV type 1 strains, BCF-Dioum and BCF-Kita, originating from the Democratic Republic of Congo (DRC).
Autor/in / Beteiligte Person:	Huang, DD ; Foley, BT ; Tolzmann, CA ; Ouma, A ; Bremer, JW
Zeitschrift:	AIDS research and human retroviruses, Jg. 25 (2009-10-01), Heft 10, S. 1039
Veröffentlichung:	Larchmont, NY : Mary Ann Liebert ; <i>Original Publication</i>: [New York] : Mary Ann Liebert, [c1987-, 2009
Medientyp:	academicJournal
ISSN:	1931-8405 (electronic)
DOI:	10.1089/aid.2009.0078
Schlagwort:	Cluster Analysis Democratic Republic of the Congo Evolution, Molecular Genotype HIV-1 isolation & purification Humans Molecular Sequence Data Phylogeny Recombination, Genetic Sequence Analysis, DNA Sequence Homology Genome, Viral HIV Infections virology HIV-1 classification HIV-1 genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Language: English [AIDS Res Hum Retroviruses] 2009 Oct; Vol. 25 (10), pp. 1039-43. MeSH Terms: Genome, Viral* ; HIV Infections / virology ; HIV-1 / classification ; HIV-1 / *genetics ; Cluster Analysis ; Democratic Republic of the Congo ; Evolution, Molecular ; Genotype ; HIV-1 / isolation & purification ; Humans ; Molecular Sequence Data ; Phylogeny ; Recombination, Genetic ; Sequence Analysis, DNA ; Sequence Homology References: AIDS Res Hum Retroviruses. 1998 Nov 1;14(16):1495-500. (PMID: 9824329) ; J Acquir Immune Defic Syndr. 2002 Apr 15;29(5):522-30. (PMID: 11981370) ; AIDS Res Hum Retroviruses. 1995 Nov;11(11):1423-5. (PMID: 8573403) ; Syst Biol. 2003 Oct;52(5):696-704. (PMID: 14530136) ; AIDS Res Hum Retroviruses. 2005 Jul;21(7):661-6. (PMID: 16060838) ; Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W557-9. (PMID: 15980534) ; AIDS Res Hum Retroviruses. 2003 Apr;19(4):321-8. (PMID: 12816082) ; AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):139-51. (PMID: 10659053) ; J Virol. 1999 Jan;73(1):152-60. (PMID: 9847317) ; J Virol. 2000 Nov;74(22):10498-507. (PMID: 11044094) ; AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1351-4. (PMID: 9339853) ; Virology. 2003 Nov 10;316(1):116-25. (PMID: 14599796) ; Science. 2003 May 30;300(5624):1394-9. (PMID: 12730500) ; Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W654-9. (PMID: 15215470) ; Comput Appl Biosci. 1996 Aug;12(4):357-8. (PMID: 8902363) Grant Information: HHSN266200500044C United States PHS HHS; N01-AI-50044 United States AI NIAID NIH HHS; N01-AI-85354 United States AI NIAID NIH HHS Molecular Sequence: GENBANK FJ183725; FJ183726 Entry Date(s): Date Created: 20091003 Date Completed: 20091216 Latest Revision: 20211020 Update Code: 20240513 PubMed Central ID: PMC2828238

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