Urinary soluble egg antigen levels in Schistosoma haematobium infection in relation to sex and age of Kenyan schoolchildren following praziquantel treatment.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Jg. 103 (2009-10-01), Heft 10, S. 1024-30
Online
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Zugriff:
Schistosoma haematobium soluble egg antigen (SEA) secreted in urine can be assayed to determine egg tissue load and hence morbidity in infected individuals. A cohort of 158 infected children aged 4-18 years was followed-up for 33 days pre and post treatment with a single dose of praziquantel. There was a significant difference in the prevalence of S. haematobium between males and females (P < 0.05). There were also significant differences in egg counts between age group < or = 5 years compared with 6-8 years, 9-11 years and 12-14 years, and age group > or = 15 years compared with 6-8 years, 9-11 years and 12-14 years (P < 0.05). Comparison of SEA among age groups indicated a significant difference between age group < or = 5 years compared with 9-11 years, 12-14 years and > or = 15 years, and age group > or = 15 years compared with 9-11 years and 12-14 years (P < 0.05). There was a statistically significant correlation between levels of SEA and egg output (r2=0.961, P=0.010). These results are useful in the development of a SEA-based dipstick assay for field diagnosis of urinary schistosomiasis.
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Urinary soluble egg antigen levels in Schistosoma haematobium infection in relation to sex and age of Kenyan schoolchildren following praziquantel treatment.
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Autor/in / Beteiligte Person: | Kihara, JH ; Njagi, EN ; Kenya, EU ; Mwanje, MT ; Odek, AE ; van Dam G ; Kahama, AI ; Ouma, JH |
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Zeitschrift: | Transactions of the Royal Society of Tropical Medicine and Hygiene, Jg. 103 (2009-10-01), Heft 10, S. 1024-30 |
Veröffentlichung: | 2013- : Oxford : Oxford University Press ; <i>Original Publication</i>: 1920- : London : Royal Society of Tropical Medicine and Hygiene, 2009 |
Medientyp: | academicJournal |
ISSN: | 1878-3503 (electronic) |
DOI: | 10.1016/j.trstmh.2009.04.021 |
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