Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study.
In: Brain research, Jg. 1294 (2009-10-19), S. 144
Online
academicJournal
Zugriff:
NXY-059, a polar compound with limited transport across the blood-brain barrier, has demonstrated neuroprotection in several animal models of acute ischemic stroke but failed to confirm clinical benefit in the second phase III trial (SAINT-II). To improve the understanding of the mechanisms responsible for its neuroprotective action in preclinical models a series of experiments was carried out in an in vitro blood-brain barrier (BBB) model. A clinically attainable concentration of 250 mumol/L of NXY-059 administered at the onset or up to 4 h after oxygen glucose deprivation (OGD) produced a significant reduction in the increased BBB permeability caused by OGD. Furthermore, OGD produced a huge influx of tissue plasminogen activator across the BBB, which was substantially reduced by NXY-059. This study suggests that the neuroprotective effects of NXY-059 preclinically, may at least in part be attributed to its ability to restore functionality of the brain endothelium.
Titel: |
Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study.
|
---|---|
Autor/in / Beteiligte Person: | Culot, M ; Mysiorek, C ; Renftel, M ; Roussel, BD ; Hommet, Y ; Vivien, D ; Cecchelli, R ; Fenart, L ; Berezowski, V ; Dehouck, MP ; Lundquist, S |
Link: | |
Zeitschrift: | Brain research, Jg. 1294 (2009-10-19), S. 144 |
Veröffentlichung: | Amsterdam Elsevier/North-Holland Biomedical Press., 2009 |
Medientyp: | academicJournal |
ISSN: | 1872-6240 (electronic) |
DOI: | 10.1016/j.brainres.2009.07.035 |
Schlagwort: |
|
Sonstiges: |
|