Identification of new inhibitors for alternative NADH dehydrogenase (NDH-II).
In: FEMS microbiology letters, Jg. 291 (2009-02-01), Heft 2, S. 157-61
Online
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Zugriff:
In bacterial membranes and plant, fungus and protist mitochondria, NADH dehydrogenase (NDH-II) serves as an alternative NADH : quinone reductase, a non-proton-pumping single-subunit enzyme bound to the membrane surface. Because NDH-II is absent in mammalian mitochondria, it is a promising target for new antibiotics. However, inhibitors for NDH-II are rare and unspecific. Taking advantage of the simple organization of the respiratory chain in Gluconobacter oxydans, we carried out screening of natural compounds and identified scopafungin and gramicidin S as inhibitors for G. oxydans NDH-II. Further, we examined their effects on Mycobacterium smegmatis and Plasmodium yoelii NDH-II as model pathogen enzymes.
| Titel: |
Identification of new inhibitors for alternative NADH dehydrogenase (NDH-II).
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| Autor/in / Beteiligte Person: | Mogi, T ; Matsushita, K ; Murase, Y ; Kawahara, K ; Miyoshi, H ; Ui, H ; Shiomi, K ; Omura, S ; Kita, K |
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| Zeitschrift: | FEMS microbiology letters, Jg. 291 (2009-02-01), Heft 2, S. 157-61 |
| Veröffentlichung: | 2015- : Oxford Oxford University Press ; <i>Original Publication</i>: Amsterdam, Published by Elsevier/North Holland on behalf of the Federation of European Microbiological Societies., 2009 |
| Medientyp: | academicJournal |
| ISSN: | 1574-6968 (electronic) |
| DOI: | 10.1111/j.1574-6968.2008.01451.x |
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