Einzeltreffer — DigiBib

ADAMTS9 is a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) genes, with aggrecan-degrading activity. It has also been characterized to be reactive and highly activated ADAMTS by IL-1 beta in both chondrosarcoma cells and human chondrocytes (Demircan et al. Arthritis Rheum 52:1451-1460, 2005). In order to understand the regulation of ADAMTS9 gene expression a functional 3.0 kb human ADAMTS9 promoter has been cloned and characterized. A sequence analysis of the promoter revealed the presence of putative binding sites for Nuclear Factor of Activated T cells (NFAT), which is commonly found in the ADAMTS4 and ADAMTS5 promoters. NFATc1 was up-regulated in an activated form by IL-1 beta in human chondrocytes. The IL-1 beta inducible ADAMTS9 expression was inhibited by NFAT inhibitors, FK506 and 11Arg (11R)-VIVIT. Furthermore, direct binding of NFATc1 on distal and proximal promoters of ADAMTS9 was demonstrated by a chromatin immunoprecipitation assay. Promoter-reporter assays supported those results. These findings may provide a better understanding of the regulation of ADAMTS9 expression induced by inflammatory cytokines.

Titel:	ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes.
Autor/in / Beteiligte Person:	Yaykasli, KO ; Oohashi, T ; Hirohata, S ; Hatipoglu, OF ; Inagawa, K ; Demircan, K ; Ninomiya, Y
Link:	Zum Volltext
Zeitschrift:	Molecular and cellular biochemistry, Jg. 323 (2009-03-01), Heft 1-2, S. 69-79
Veröffentlichung:	New York : Springer ; <i>Original Publication</i>: The Hague, Dr. W. Junk B. V. Publishers., 2009
Medientyp:	academicJournal
ISSN:	1573-4919 (electronic)
DOI:	10.1007/s11010-008-9965-4
Schlagwort:	ADAM Proteins genetics ADAMTS9 Protein Animals Base Sequence Cartilage, Articular cytology Cartilage, Articular metabolism Cells, Cultured Chondrocytes cytology Enzyme Activation Humans Interleukin-1beta genetics Molecular Sequence Data NFATC Transcription Factors genetics Promoter Regions, Genetic Protein Isoforms genetics Rats ADAM Proteins metabolism Chondrocytes metabolism Chondrosarcoma metabolism Interleukin-1beta metabolism NFATC Transcription Factors metabolism Protein Isoforms metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Mol Cell Biochem] 2009 Mar; Vol. 323 (1-2), pp. 69-79. <i>Date of Electronic Publication: </i>2008 Dec 04. MeSH Terms: ADAM Proteins / metabolism ; Chondrocytes / metabolism ; Chondrosarcoma / metabolism ; Interleukin-1beta / metabolism ; NFATC Transcription Factors / metabolism ; Protein Isoforms / metabolism ; ADAM Proteins / genetics ; ADAMTS9 Protein ; Animals ; Base Sequence ; Cartilage, Articular / cytology ; Cartilage, Articular / metabolism ; Cells, Cultured ; Chondrocytes / cytology ; Enzyme Activation ; Humans ; Interleukin-1beta / genetics ; Molecular Sequence Data ; NFATC Transcription Factors / genetics ; Promoter Regions, Genetic ; Protein Isoforms / genetics ; Rats References: Cardiovasc Drug Rev. 2007 Summer;25(2):175-87. (PMID: 17614939) ; Nat Med. 2004 Mar;10(3):305-9. (PMID: 14770176) ; Cell. 2002 Apr;109 Suppl:S67-79. (PMID: 11983154) ; Biochem Biophys Res Commun. 2006 Jun 23;345(1):197-204. (PMID: 16677612) ; Int J Biochem Cell Biol. 2004 Jun;36(6):981-5. (PMID: 15094112) ; Nat Med. 2005 Aug;11(8):880-5. (PMID: 16041384) ; Nature. 1995 Dec 7;378(6557):641-4. (PMID: 8524402) ; Science. 1999 Sep 24;285(5436):2129-33. (PMID: 10497131) ; Front Biosci. 2006 Jan 01;11:544-69. (PMID: 16146752) ; Cell Mol Life Sci. 2005 Oct;62(19-20):2241-56. (PMID: 16143826) ; Ann N Y Acad Sci. 1999 Jun 30;878:92-107. (PMID: 10415722) ; J Cell Biochem. 2005 May 1;95(1):17-23. (PMID: 15759284) ; FEBS Lett. 2000 Aug 4;478(3):241-5. (PMID: 10930576) ; Genes Dev. 2003 Sep 15;17(18):2205-32. (PMID: 12975316) ; Matrix Biol. 2002 Oct;21(6):499-511. (PMID: 12392761) ; Cell. 1995 Aug 11;82(3):507-22. (PMID: 7543369) ; Science. 1999 Jun 4;284(5420):1664-6. (PMID: 10356395) ; J Anat. 1997 Jul;191 ( Pt 1):1-13. (PMID: 9279653) ; Int J Cancer. 1998 Sep 11;77(6):854-9. (PMID: 9714054) ; Gene Ther. 2000 Feb;7(4):286-91. (PMID: 10694808) ; Exp Cell Res. 2007 Jan 1;313(1):168-78. (PMID: 17084841) ; J Neurosci. 2001 Aug 15;21(16):6000-7. (PMID: 11487623) ; J Biol Chem. 2003 Nov 14;278(46):45539-45. (PMID: 12890681) ; J Biochem. 2004 Oct;136(4):439-46. (PMID: 15625312) ; Arthritis Rheum. 2005 May;52(5):1451-60. (PMID: 15880812) ; J Cell Biol. 2002 Mar 4;156(5):771-4. (PMID: 11877454) ; Eur J Immunol. 2003 Jan;33(1):1-11. (PMID: 12594826) ; J Biochem. 2003 May;133(5):633-9. (PMID: 12801915) ; Mol Biol Rep. 2007 Dec;34(4):225-31. (PMID: 17211519) ; FASEB J. 2006 Sep;20(11):1904-6. (PMID: 16877525) Substance Nomenclature: 0 (Interleukin-1beta) ; 0 (NFATC Transcription Factors) ; 0 (Protein Isoforms) ; EC 3.4.24.- (ADAM Proteins) ; EC 3.4.24.- (ADAMTS9 Protein) ; EC 3.4.24.- (ADAMTS9 protein, human) Entry Date(s): Date Created: 20081205 Date Completed: 20091201 Latest Revision: 20211020 Update Code: 20231215

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ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes.