Association of estrogen receptor alpha and interleukin-10 gene polymorphisms with endometriosis in a Chinese population.
In: Fertility and sterility, Jg. 92 (2009-07-01), Heft 1, S. 54
academicJournal
Zugriff:
Objective: To determine whether polymorphisms of the estrogen receptor alpha (ERalpha) and interleukin-10 (IL-10) genes are associated with endometriosis in a Chinese population.
Design: Association study.
Setting: University hospital.
Patient(s): Chinese women diagnosed with endometriosis by laparotomy or laparoscopy.
Intervention(s): Determination of polymorphisms of the ERalpha and IL-10 genes was performed by polymerase chain reaction and restriction fragment length polymorphism analysis in 214 affected women and 160 controls.
Main Outcome Measure(s): Frequency and distribution of PvuII and XbaI polymorphisms of ERalpha and of BslI, SspI, and RsaI polymorphisms of IL-10.
Result(s): There was no significant difference between the endometriosis patients and the control groups in the genotype frequency of ERalpha-PvuII and promoter of IL-10 gene polymorphisms in the position of -1082. However, the frequency of ERalpha-XbaI and -592 or -819C alleles of IL-10 in the endometriosis group was significantly higher than that of controls, and further analysis showed that the X allele of ERalpha-XbaI was associated with endometriosis.
Conclusion(s): The X allele of ERalpha-XbaI and the -592 or -819 C allele of IL-10 are associated with endometriosis.
Titel: |
Association of estrogen receptor alpha and interleukin-10 gene polymorphisms with endometriosis in a Chinese population.
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Autor/in / Beteiligte Person: | Xie, J ; Wang, S ; He, B ; Pan, Y ; Li, Y ; Zeng, Q ; Jiang, H ; Chen, J |
Zeitschrift: | Fertility and sterility, Jg. 92 (2009-07-01), Heft 1, S. 54 |
Veröffentlichung: | New York. NY : Elsevier for the American Society for Reproductive Medicine ; <i>Original Publication</i>: New York, Hoeber., 2009 |
Medientyp: | academicJournal |
ISSN: | 1556-5653 (electronic) |
DOI: | 10.1016/j.fertnstert.2008.04.069 |
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