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Background: We hypothesised that human fetal cardiac natriuretic peptide secretion is increased in type-1 diabetic pregnancies with normal placental hemodynamics, and this increase is related to the first trimester maternal glycemic control.

Methods: Thirty-two neonates of type-1 diabetic mothers and 60 neonates born after uncomplicated pregnancy and labour (control group) were included in this study. Diabetic pregnancies were divided into two subgroups based on the first trimester HbA1c value. Group 1 pregnancies (n =22) had a good glycemic control (HbA1c <7.5%) and Group 2 pregnancies (n =10) had a poor glycemic control (HbA1c > or =7.5%). At delivery, an umbilical artery (UA) blood sample was obtained for assessment of N-terminal peptide of proatrial (NT-proANP) and proB-type (NT-proBNP) natriuretic peptide levels. In diabetic pregnancies, each fetus had normal UA Doppler velocimetry for gestational age.

Results: The newborn UA NT-proANP and NT-proBNP concentrations were significantly higher in type-1 diabetic pregnancies than in the control group. Group 2 fetuses with poor glycemic control showed significantly higher UA NT-proANP levels than Group 1 fetuses. UA NT-proANP levels correlated significantly with maternal HbA1c values in the first, second and third trimesters, while UA NT-proBNP levels did not correlate with maternal HbA1c values.

Conclusions: In type-1 diabetic pregnancies, fetal cardiac natriuretic peptide secretion is increased, even in the presence of good glycemic control and normal placental hemodynamics. In addition, fetal NT-proANP levels are already related to maternal glycemic control in the first trimester of pregnancy.

Titel:	Increased fetal cardiac natriuretic peptide secretion in type-1 diabetic pregnancies.
Autor/in / Beteiligte Person:	Girsen, A ; Ala-Kopsala, M ; Mäkikallio, K ; Vuolteenaho, O ; Räsänen, J
Link:	Zum Volltext
Zeitschrift:	Acta obstetricia et gynecologica Scandinavica, Jg. 87 (2008), Heft 3, S. 307-12
Veröffentlichung:	2011- : Malden, MA : Wiley ; <i>Original Publication</i>: Copenhagen : Munksgaard, 2008
Medientyp:	academicJournal
ISSN:	1600-0412 (electronic)
DOI:	10.1080/00016340801899990
Schlagwort:	Atrial Natriuretic Factor metabolism Blood Flow Velocity physiology Cross-Sectional Studies Diabetes Mellitus, Type 1 diagnostic imaging Female Humans Infant, Newborn Natriuretic Peptide, Brain metabolism Peptide Fragments metabolism Pregnancy Pregnancy in Diabetics diagnostic imaging Protein Precursors metabolism Ultrasonography Atrial Natriuretic Factor blood Diabetes Mellitus, Type 1 physiopathology Natriuretic Peptide, Brain blood Peptide Fragments blood Pregnancy in Diabetics physiopathology Protein Precursors blood Umbilical Arteries diagnostic imaging
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Acta Obstet Gynecol Scand] 2008; Vol. 87 (3), pp. 307-12. MeSH Terms: Atrial Natriuretic Factor / blood ; Diabetes Mellitus, Type 1 / physiopathology ; Natriuretic Peptide, Brain / blood ; Peptide Fragments / blood ; Pregnancy in Diabetics / physiopathology ; Protein Precursors / blood ; Umbilical Arteries / *diagnostic imaging ; Atrial Natriuretic Factor / metabolism ; Blood Flow Velocity / physiology ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1 / diagnostic imaging ; Female ; Humans ; Infant, Newborn ; Natriuretic Peptide, Brain / metabolism ; Peptide Fragments / metabolism ; Pregnancy ; Pregnancy in Diabetics / diagnostic imaging ; Protein Precursors / metabolism ; Ultrasonography Substance Nomenclature: 0 (N-terminal proatrial natriuretic peptide) ; 0 (Peptide Fragments) ; 0 (Protein Precursors) ; 0 (pro-brain natriuretic peptide (1-76)) ; 114471-18-0 (Natriuretic Peptide, Brain) ; 85637-73-6 (Atrial Natriuretic Factor) Entry Date(s): Date Created: 20080301 Date Completed: 20080327 Latest Revision: 20181201 Update Code: 20240513

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Increased fetal cardiac natriuretic peptide secretion in type-1 diabetic pregnancies.